Entity Details

Primary name MRP4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15439
EntryNameMRP4_HUMAN
FullNameATP-binding cassette sub-family C member 4
TaxID9606
Evidenceevidence at protein level
Length1325
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesABCC4

GO terms

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GOName
GO:0001409 guanine nucleotide transmembrane transporter activity
GO:0002576 platelet degranulation
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0008559 ABC-type xenobiotic transporter activity
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0015132 prostaglandin transmembrane transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015216 purine nucleotide transmembrane transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015432 ABC-type bile acid transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0015721 bile acid and bile salt transport
GO:0015732 prostaglandin transport
GO:0015747 urate transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0031088 platelet dense granule membrane
GO:0032310 prostaglandin secretion
GO:0034634 glutathione transmembrane transporter activity
GO:0038183 bile acid signaling pathway
GO:0042493 response to drug
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0055085 transmembrane transport
GO:0060271 cilium assembly
GO:0070730 cAMP transport
GO:0071716 leukotriene transport
GO:0098591 external side of apical plasma membrane
GO:0140115 export across plasma membrane
GO:0150104 transport across blood-brain barrier

Subcellular Location

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Subcellular Location
Apical cell membrane
Basolateral cell membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030240 ATP-binding cassette sub-family C member 4FamilyFamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00158 Folic acidDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule
DB00198 OseltamivirDrugbanksmall molecule
DB00203 SildenafilDrugbanksmall molecule
DB00286 Conjugated estrogensDrugbanksmall molecule
DB00300 Tenofovir disoproxilDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00352 TioguanineSwissprotsmall molecule
DB00398 SorafenibDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00482 CelecoxibDrugbanksmall molecule
DB00495 ZidovudineDrugbanksmall molecule
DB00533 RofecoxibDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00712 FlurbiprofenDrugbanksmall molecule
DB00718 Adefovir dipivoxilDrugbanksmall molecule
DB00731 NateglinideDrugbanksmall molecule
DB00770 AlprostadilDrugbanksmall molecule
DB00814 MeloxicamDrugbanksmall molecule
DB00917 DinoprostoneDrugbanksmall molecule
DB00975 DipyridamoleDrugbanksmall molecule
DB00999 HydrochlorothiazideDrugbanksmall molecule
DB01009 KetoprofenDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01033 MercaptopurineDrugbanksmall molecule
DB01050 IbuprofenDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01098 RosuvastatinDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB01327 CefazolinDrugbanksmall molecule
DB01586 Ursodeoxycholic acidDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB02527 Cyclic adenosine monophosphateDrugbanksmall molecule
DB02659 Cholic AcidDrugbanksmall molecule
DB04348 Taurocholic acidDrugbanksmall molecule
DB08884 Gadoxetic acidSwissprotsmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09299 Tenofovir alafenamideDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule
DB13146 Fluciclovine (18F)Drugbanksmall molecule
DB14126 TenofovirDrugbanksmall molecule
DB14761 RemdesivirDrugbanksmall molecule