Entity Details

Primary name PA2GX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15496
EntryNamePA2GX_HUMAN
FullNameGroup 10 secretory phospholipase A2
TaxID9606
Evidenceevidence at protein level
Length165
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesPLA2G10

GO terms

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GOName
GO:0001669 acrosomal vesicle
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0004620 phospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006658 phosphatidylserine metabolic process
GO:0007411 axon guidance
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010884 positive regulation of lipid storage
GO:0019369 arachidonic acid metabolic process
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032308 positive regulation of prostaglandin secretion
GO:0034374 low-density lipoprotein particle remodeling
GO:0034638 phosphatidylcholine catabolic process
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0042632 cholesterol homeostasis
GO:0043030 regulation of macrophage activation
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0046337 phosphatidylethanolamine metabolic process
GO:0046470 phosphatidylcholine metabolic process
GO:0046471 phosphatidylglycerol metabolic process
GO:0046473 phosphatidic acid metabolic process
GO:0047498 calcium-dependent phospholipase A2 activity
GO:0050482 arachidonic acid secretion
GO:0051607 defense response to virus
GO:0051977 lysophospholipid transport
GO:0062234 platelet activating factor catabolic process
GO:0090238 positive regulation of arachidonic acid secretion
GO:0090370 negative regulation of cholesterol efflux
GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
GO:2000344 positive regulation of acrosome reaction

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR001211 Phospholipase A2FamilyFamily
IPR016090 Phospholipase A2 domainDomainDomain
IPR033112 Phospholipase A2, aspartic acid active siteSiteActive site
IPR033113 Phospholipase A2, histidine active siteSiteActive site
IPR036444 Phospholipase A2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05737 Varespladib methylDrugbanksmall molecule
DB13892 Crotalus atrox antiveninSwissprotbiotech
DB13893 Crotalus adamanteus antiveninDrugbankbiotech
DB13894 Agkistrodon piscivorus antiveninDrugbankbiotech

Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
PA2GX_HUMANMYO10_HUMANHPRD, IntAct16169070 details
PA2GX_HUMANVGLL3_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANKR261_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANKR111_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANATX1_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANHSF4_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANAQP1_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANSTK16_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANBAG3_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANTLX3_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANRU1C_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANTFG_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANHAIR_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANSPYA_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANPPR32_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANFOXH1_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANHGS_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANKPRP_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANLCE2B_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANARI5A_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANOTX1_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANBEX2_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANLCE1A_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANNOXA1_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANMAL_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANMABP1_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANGATA5_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANCTSR1_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANTBX6_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANCREB5_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANCC120_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANPO4F3_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANLCE1C_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANLCE2A_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANCA094_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANF222B_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANGLCNE_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANROR2_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANPITX1_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANVP37C_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANSPAG8_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANNTAQ1_HUMANBioGRID, IntAct28514442 32296183 details
PA2GX_HUMANHXC8_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANLCE2D_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANZC3HA_HUMANBioGRID, IntAct32296183 details
PA2GX_HUMANSPRE1_HUMANIntAct32814053 details
PA2GX_HUMANMGT5B_HUMANBioGRID32296183 details
PA2GX_HUMANPLA2R_HUMANHPRD10922494 11019817 details