Entity Details

Primary name DAPK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43293
EntryNameDAPK3_HUMAN
FullNameDeath-associated protein kinase 3
TaxID9606
Evidenceevidence at protein level
Length454
SequenceStatuscomplete
DateCreated2003-11-28
DateModified2021-06-02

Ontological Relatives

GenesDAPK3

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006940 regulation of smooth muscle contraction
GO:0007088 regulation of mitotic nuclear division
GO:0007346 regulation of mitotic cell cycle
GO:0008022 protein C-terminus binding
GO:0008140 cAMP response element binding protein binding
GO:0008360 regulation of cell shape
GO:0010506 regulation of autophagy
GO:0016605 PML body
GO:0017148 negative regulation of translation
GO:0030182 neuron differentiation
GO:0030335 positive regulation of cell migration
GO:0031267 small GTPase binding
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043519 regulation of myosin II filament organization
GO:0043522 leucine zipper domain binding
GO:0045121 membrane raft
GO:0046777 protein autophosphorylation
GO:0051893 regulation of focal adhesion assembly
GO:0071346 cellular response to interferon-gamma
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097190 apoptotic signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000145 regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR042870 DAPK3, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04716 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-oneDrugbanksmall molecule
DB07125 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acidDrugbanksmall molecule
DB07242 (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrileDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
DAPK3_HUMANPAWR_HUMANBioGRID, HPRD, IntAct10602480 12917339 15001356 details
DAPK3_HUMANDAPK3_HUMANBioGRID, HPRD, MINT, UniProt15001356 18082144 18239682 21487036 23146908 9488481 details
DAPK3_HUMANRL34_HUMANBioGRID, IntAct21988832 details
DAPK3_HUMANKAD3_HUMANBioGRID, IntAct21988832 details
DAPK3_HUMANTCP1L_HUMANBioGRID, IntAct, UniProt15910542 21988832 details
DAPK3_HUMANML12B_HUMANUniProt17126281 21487036 details
DAPK3_HUMANRHOD_HUMANUniProt23454120 details
DAPK3_HUMANGRB14_HUMANBioGRID12242277 details
DAPK3_HUMANKPCZ_HUMANBioGRID, HPRD12242277 details
DAPK3_HUMANNED4L_HUMANBioGRID19953087 details
DAPK3_HUMANRAD21_HUMANBioGRID22145905 details
DAPK3_HUMANCDN1A_HUMANBioGRID, HPRD15001356 details
DAPK3_HUMANMDM2_HUMANBioGRID15001356 23146908 details
DAPK3_HUMANP53_HUMANBioGRID15001356 details
DAPK3_HUMANCHK2_HUMANBioGRID15001356 details
DAPK3_HUMANAATF_HUMANBioGRID, HPRD10580117 23146908 details
DAPK3_HUMANOGT1_HUMANBioGRID32994395 details
DAPK3_HUMANMET_HUMANHPRD15546961 details
DAPK3_HUMANDAXX_HUMANBioGRID, IntAct12917339 details
DAPK3_HUMANHS90B_HUMANIntAct22939624 details
DAPK3_HUMANCDC37_HUMANIntAct25036637 details
DAPK3_HUMANSTAT3_HUMANUniProt16219639 details
DAPK3_HUMANNLK_HUMANUniProt21454679 details
DAPK3_HUMANMYPT1_HUMANUniProt15292222 details
DAPK3_HUMANATF4_HUMANHPRD, UniProt21408167 9488481 details
DAPK3_HUMANUB2D3_HUMANBioGRID18515077 details
DAPK3_HUMANANDR_HUMANBioGRID23146908 details
DAPK3_HUMANTS101_HUMANBioGRID23146908 details
DAPK3_HUMANULK1_HUMANBioGRID21169990 details