Entity Details

Primary name CP39A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NYL5
EntryNameCP39A_HUMAN
FullName24-hydroxycholesterol 7-alpha-hydroxylase
TaxID9606
Evidenceevidence at protein level
Length469
SequenceStatuscomplete
DateCreated2002-01-23
DateModified2021-06-02

Ontological Relatives

GenesCYP39A1

GO terms

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GOName
GO:0005506 iron ion binding
GO:0005789 endoplasmic reticulum membrane
GO:0006699 bile acid biosynthetic process
GO:0006707 cholesterol catabolic process
GO:0007586 digestion
GO:0008387 steroid 7-alpha-hydroxylase activity
GO:0008395 steroid hydroxylase activity
GO:0008396 oxysterol 7-alpha-hydroxylase activity
GO:0016021 integral component of membrane
GO:0016125 sterol metabolic process
GO:0020037 heme binding
GO:0042632 cholesterol homeostasis
GO:0043231 intracellular membrane-bounded organelle

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002403 Cytochrome P450, E-class, group IVFamilyFamily
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-typeFamilyFamily
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
CP39A_HUMANGLNA_HUMANBioGRID, IntAct21988832 details
CP39A_HUMANA1AG2_HUMANBioGRID, IntAct21988832 details
CP39A_HUMANSERC1_HUMANBioGRID, IntAct21988832 details
CP39A_HUMANSMYD3_HUMANBioGRID, IntAct21988832 details