Entity Details

Primary name NLGN3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NZ94
EntryNameNLGN3_HUMAN
FullNameNeuroligin-3
TaxID9606
Evidenceevidence at protein level
Length848
SequenceStatuscomplete
DateCreated2003-05-23
DateModified2021-06-02

Ontological Relatives

GenesNLGN3

GO terms

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GOName
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0007158 neuron cell-cell adhesion
GO:0007268 chemical synaptic transmission
GO:0007416 synapse assembly
GO:0007612 learning
GO:0009986 cell surface
GO:0030139 endocytic vesicle
GO:0030534 adult behavior
GO:0035176 social behavior
GO:0038023 signaling receptor activity
GO:0042043 neurexin family protein binding
GO:0045202 synapse
GO:0048488 synaptic vesicle endocytosis
GO:0048675 axon extension
GO:0050804 modulation of chemical synaptic transmission
GO:0050808 synapse organization
GO:0050839 cell adhesion molecule binding
GO:0051965 positive regulation of synapse assembly
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060024 rhythmic synaptic transmission
GO:0060076 excitatory synapse
GO:0060080 inhibitory postsynaptic potential
GO:0071625 vocalization behavior
GO:0089717 spanning component of membrane
GO:0097104 postsynaptic membrane assembly
GO:0097105 presynaptic membrane assembly
GO:0097110 scaffold protein binding
GO:0098793 presynapse
GO:0098983 symmetric, GABA-ergic, inhibitory synapse
GO:0098985 asymmetric, glutamatergic, excitatory synapse
GO:0099054 presynapse assembly
GO:0099055 integral component of postsynaptic membrane
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000969 positive regulation of AMPA receptor activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000460 NeuroliginFamilyFamily
IPR002018 Carboxylesterase, type BDomainDomain
IPR019819 Carboxylesterase type B, conserved siteSiteConserved site
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR030024 Neuroligin-3FamilyFamily

Diseases

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Disease IDSourceNameDescription
300494 OMIMAsperger syndrome, X-linked, 1 (ASPGX1)A syndrome with features similar to autism. Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use of non-verbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of language and communicative phrases. Disease susceptibility is associated with variants affecting the gene represented in this entry.
300425 OMIMAutism, X-linked 1 (AUTSX1)A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
NLGN3_HUMANPRDX2_HUMANBioGRID, IntAct21988832 details
NLGN3_HUMANACOT2_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANPPB1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANAP2A2_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANATF4_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANCA122_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANC1QA_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANCCAR2_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANCGB3_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANCATD_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANCP11A_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANDPEP2_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANEBPL_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANEF1A1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANEFS_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANFANCG_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANFBLN1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANFHOD1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANFKB1A_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANFLNA_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANGDF15_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANKGUA_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANHID1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANIPRI_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANLEG1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANMA2C1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANMAP1S_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANMIEN1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANCOX2_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANNFAC4_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANNRDC_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANOAZ1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANOR1FC_HUMANIntAct25464930 details
NLGN3_HUMANIPKB_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANPLCB4_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANPLB1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANSAP_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANPSG1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANPSG3_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANPSG4_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANPSG5_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANPSG11_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANSYQ_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANNADC_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANSPAG5_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANSPIT1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANSSRD_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANTNNT3_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANTRI33_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANTXNIP_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANUBXN6_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANQCR1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANDLG4_HUMANBioGRID, HPRD9278515 details
NLGN3_HUMANDLG3_HUMANBioGRID, HPRD9278515 details
NLGN3_HUMANDLG2_HUMANBioGRID, HPRD9278515 details
NLGN3_HUMANNRX1B_HUMANBioGRID8576240 details
NLGN3_HUMANNRX1A_HUMANBioGRID, HPRD8576240 9325340 details
NLGN3_HUMANNRX3B_HUMANBioGRID8576240 details
NLGN3_HUMANNRX3A_HUMANBioGRID, HPRD8576240 details
NLGN3_HUMANMEOX2_HUMANBioGRID24722188 details
NLGN3_HUMANUBQL1_HUMANBioGRID26871637 details
NLGN3_HUMANTPRA1_HUMANBioGRID, IntAct25464930 details
NLGN3_HUMANATX1_HUMANMINT21653829 details
NLGN3_HUMANAPCL_HUMANMINT21653829 details
NLGN3_HUMANAKT1_HUMANMINT21653829 details
NLGN3_HUMANTLE5_HUMANMINT21653829 details
NLGN3_HUMANCOBL_HUMANMINT21653829 details
NLGN3_HUMANTDRD7_HUMANMINT21653829 details
NLGN3_HUMANRFOX2_HUMANMINT21653829 details
NLGN3_HUMANPICK1_HUMANMINT21653829 details
NLGN3_HUMANZEP1_HUMANMINT21653829 details
NLGN3_HUMANFBLN3_HUMANMINT21653829 details
NLGN3_HUMANNRX2A_HUMANHPRD8576240 details