Entity Details

Primary name MBD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBB5
EntryNameMBD2_HUMAN
FullNameMethyl-CpG-binding domain protein 2
TaxID9606
Evidenceevidence at protein level
Length411
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesMBD2

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000183 rDNA heterochromatin assembly
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0003682 chromatin binding
GO:0003696 satellite DNA binding
GO:0003729 mRNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006346 DNA methylation-dependent heterochromatin assembly
GO:0007507 heart development
GO:0007568 aging
GO:0008327 methyl-CpG binding
GO:0009612 response to mechanical stimulus
GO:0019904 protein domain specific binding
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031667 response to nutrient levels
GO:0032355 response to estradiol
GO:0032991 protein-containing complex
GO:0034622 cellular protein-containing complex assembly
GO:0035197 siRNA binding
GO:0035563 positive regulation of chromatin binding
GO:0042127 regulation of cell population proliferation
GO:0042711 maternal behavior
GO:0043044 ATP-dependent chromatin remodeling
GO:0044030 regulation of DNA methylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048568 embryonic organ development
GO:0070742 C2H2 zinc finger domain binding
GO:0071407 cellular response to organic cyclic compound

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001739 Methyl-CpG DNA bindingDomainDomain
IPR016177 DNA-binding domain superfamilyFamilyHomologous superfamily
IPR025884 Methyl-CpG binding protein 2/3, C-terminal domainDomainDomain
IPR032343 Methyl-CpG-binding domain protein 2/3, p55-binding regionDomainDomain

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
MBD2_HUMANP66A_HUMANBioGRID, HPRD, IntAct12183469 16415179 24981860 25753662 26264872 26344197 28514442 32296183 32814053 details
MBD2_HUMANHDAC1_HUMANBioGRID, HPRD, IntAct10444591 10471499 11102443 11297506 12183469 12665568 17634443 21258344 23752268 24981860 26496610 27173435 27593931 28514442 unassigned1312 details
MBD2_HUMANHDAC2_HUMANBioGRID, HPRD, IntAct, MINT10444591 10471499 11297506 12183469 16410616 21258344 23752268 24981860 25753662 26344197 26949739 details
MBD2_HUMANLTOR3_HUMANBioGRID, IntAct21988832 details
MBD2_HUMANPURB_HUMANBioGRID, IntAct32296183 details
MBD2_HUMANP66B_HUMANBioGRID, HPRD, IntAct11756549 12183469 16415179 24981860 26186194 26344197 28514442 details
MBD2_HUMANMTA2_HUMANBioGRID, IntAct10444591 11102443 11297506 24981860 25753662 26344197 details
MBD2_HUMANCHD3_HUMANBioGRID, IntAct10444591 11297506 24981860 28977666 details
MBD2_HUMANGPN1_HUMANBioGRID, HPRD12588985 details
MBD2_HUMANMBD3_HUMANBioGRID10444591 10947852 11297506 15456747 15701600 24981860 details
MBD2_HUMANMB3L1_HUMANBioGRID, HPRD15456747 details
MBD2_HUMANDHX9_HUMANBioGRID, HPRD12665568 details
MBD2_HUMANSIN3A_HUMANBioGRID, HPRD10950960 24981860 details
MBD2_HUMANHINFP_HUMANBioGRID, HPRD11553631 details
MBD2_HUMANMBD2_HUMANBioGRID, HPRD10947852 12183469 15701600 details
MBD2_HUMANFAK2_HUMANBioGRID19661918 details
MBD2_HUMANTACC3_HUMANBioGRID16410616 details
MBD2_HUMANMB3L2_HUMANBioGRID15701600 details
MBD2_HUMANTBP_HUMANBioGRID25363021 details
MBD2_HUMANRBBP4_HUMANBioGRID, HPRD, IntAct, MINT10471499 11297506 24981860 25753662 27705803 details
MBD2_HUMANRBBP7_HUMANBioGRID, IntAct11297506 24981860 26186194 27705803 28514442 details
MBD2_HUMANCDKA1_HUMANBioGRID, IntAct, MINT20523938 24981860 25123934 26496610 details
MBD2_HUMANRFX3_HUMANBioGRID, IntAct27173435 unassigned1312 details
MBD2_HUMANDNMT1_HUMANBioGRID, IntAct10947852 27593931 details
MBD2_HUMANESR1_HUMANBioGRID, IntAct20300195 31527615 details
MBD2_HUMANSMN_HUMANMINT21653829 details
MBD2_HUMANRALYL_HUMANMINT21653829 details
MBD2_HUMANANM1_HUMANBioGRID, MINT16980624 21653829 details
MBD2_HUMANC1QBP_HUMANMINT21653829 details
MBD2_HUMANBEND7_HUMANMINT21653829 details
MBD2_HUMANTRI27_HUMANBioGRID17049487 details
MBD2_HUMANANM5_HUMANBioGRID16428440 16980624 details
MBD2_HUMANMEP50_HUMANBioGRID16980624 28977470 details
MBD2_HUMANKDM1A_HUMANBioGRID17634443 details
MBD2_HUMANKDM5B_HUMANBioGRID21937684 details
MBD2_HUMANCHD5_HUMANBioGRID24981860 25247294 details
MBD2_HUMANRPB1_HUMANBioGRID12665568 details
MBD2_HUMANRELN_HUMANBioGRID25476119 details
MBD2_HUMANDCE1_HUMANBioGRID25476119 details
MBD2_HUMANBDNF_HUMANBioGRID25476119 details
MBD2_HUMANCBP_HUMANHPRD12665568 details