Entity Details

Primary name CNOT8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UFF9
EntryNameCNOT8_HUMAN
FullNameCCR4-NOT transcription complex subunit 8
TaxID9606
Evidenceevidence at protein level
Length292
SequenceStatuscomplete
DateCreated2001-08-14
DateModified2021-06-02

Ontological Relatives

GenesCNOT8

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 P-body
GO:0003723 RNA binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006351 transcription, DNA-templated
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008284 positive regulation of cell population proliferation
GO:0017148 negative regulation of translation
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex
GO:0035195 gene silencing by miRNA
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0046872 metal ion binding
GO:0061014 positive regulation of mRNA catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR006941 Ribonuclease CAF1FamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR027212 CCR4-NOT transcription complex subunit 8FamilyFamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR039637 CCR4-NOT transcription complex subunit 7/8/Pop2FamilyFamily

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
CNOT8_HUMANBTG1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11136725 16189514 20211142 21900206 25416956 31515488 details
CNOT8_HUMANCNOT1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10637334 16778766 17353931 22977175 26496610 details
CNOT8_HUMANCNOT3_HUMANBioGRID, HPRD, MINT, UniProt10637334 16778766 details
CNOT8_HUMANCNOT6_HUMANUniProt11747467 17452450 details
CNOT8_HUMANCNO6L_HUMANBioGRID, IntAct, UniProt17452450 29395067 32296183 details
CNOT8_HUMANBTG2_HUMANBioGRID, HPRD, IntAct, UniProt11136725 25416956 details
CNOT8_HUMANTOB2_HUMANBioGRID, IntAct25416956 details
CNOT8_HUMANPUM1_HUMANBioGRID, DIP16715093 29395067 details
CNOT8_HUMANANM1_HUMANBioGRID17264152 details
CNOT8_HUMANCNOT4_HUMANBioGRID, HPRD10637334 30692204 details
CNOT8_HUMANCNOT2_HUMANBioGRID, HPRD, IntAct, MINT16778766 26496610 29395067 details
CNOT8_HUMANEZRI_HUMANIntAct17353931 details
CNOT8_HUMANLIPM_HUMANIntAct17353931 details
CNOT8_HUMANOTUB1_HUMANIntAct17353931 details
CNOT8_HUMANMARCS_HUMANIntAct17353931 details
CNOT8_HUMANCAZA1_HUMANIntAct17353931 details
CNOT8_HUMANCYBP_HUMANIntAct17353931 details
CNOT8_HUMANTNR6C_HUMANBioGRID, UniProt21981923 21984184 29395067 details
CNOT8_HUMANAGO2_HUMANBioGRID, UniProt21981923 details
CNOT8_HUMANTNR6B_HUMANBioGRID, UniProt21981923 29395067 details
CNOT8_HUMANTNR6A_HUMANBioGRID, UniProt21981923 29395067 details
CNOT8_HUMANUNK_HUMANBioGRID25737280 29395067 details
CNOT8_HUMANRC3H1_HUMANBioGRID26170170 details
CNOT8_HUMANTTP_HUMANBioGRID21078877 29395067 details
CNOT8_HUMANZ3H7A_HUMANBioGRID29395067 30995489 details
CNOT8_HUMANGRRE1_HUMANBioGRID29395067 details
CNOT8_HUMANMEX3B_HUMANBioGRID29395067 details
CNOT8_HUMANOBI1_HUMANBioGRID29395067 details
CNOT8_HUMANYTHD2_HUMANBioGRID29395067 details
CNOT8_HUMANHELZ_HUMANBioGRID29395067 details
CNOT8_HUMANYTHD3_HUMANBioGRID29395067 details