Entity Details

Primary name STAP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9ULZ2
EntryNameSTAP1_HUMAN
FullNameSignal-transducing adaptor protein 1
TaxID9606
Evidenceevidence at protein level
Length295
SequenceStatuscomplete
DateCreated2005-04-12
DateModified2021-06-02

Ontological Relatives

GenesSTAP1

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005157 macrophage colony-stimulating factor receptor binding
GO:0005543 phospholipid binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0010628 positive regulation of gene expression
GO:0010760 negative regulation of macrophage chemotaxis
GO:0019901 protein kinase binding
GO:0032991 protein-containing complex
GO:0035591 signaling adaptor activity
GO:0042326 negative regulation of phosphorylation
GO:0043231 intracellular membrane-bounded organelle
GO:0050861 positive regulation of B cell receptor signaling pathway
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0071222 cellular response to lipopolysaccharide
GO:1900028 negative regulation of ruffle assembly
GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1903980 positive regulation of microglial cell activation
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:1904140 negative regulation of microglial cell migration
GO:1904151 positive regulation of microglial cell mediated cytotoxicity
GO:2000251 positive regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR035877 STAP1, SH2 domainDomainDomain
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR039111 Signal-transducing adaptor protein STAP1/STAP2FamilyFamily

Diseases

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