Entity Details

Primary name ASC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9ULZ3
EntryNameASC_HUMAN
FullNameApoptosis-associated speck-like protein containing a CARD
TaxID9606
Evidenceevidence at protein level
Length195
SequenceStatuscomplete
DateCreated2001-10-18
DateModified2021-06-02

Ontological Relatives

GenesPYCARD

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001773 myeloid dendritic cell activation
GO:0002020 protease binding
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0002277 myeloid dendritic cell activation involved in immune response
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0002821 positive regulation of adaptive immune response
GO:0005138 interleukin-6 receptor binding
GO:0005523 tropomyosin binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0008385 IkappaB kinase complex
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010506 regulation of autophagy
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0017024 myosin I binding
GO:0019899 enzyme binding
GO:0030838 positive regulation of actin filament polymerization
GO:0031647 regulation of protein stability
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032090 Pyrin domain binding
GO:0032688 negative regulation of interferon-beta production
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034774 secretory granule lumen
GO:0035578 azurophil granule lumen
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042104 positive regulation of activated T cell proliferation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043312 neutrophil degranulation
GO:0044325 transmembrane transporter binding
GO:0044351 macropinocytosis
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0046983 protein dimerization activity
GO:0050727 regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050829 defense response to Gram-negative bacterium
GO:0050870 positive regulation of T cell activation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051260 protein homooligomerization
GO:0051607 defense response to virus
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070700 BMP receptor binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072558 NLRP1 inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097169 AIM2 inflammasome complex
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:2000406 positive regulation of T cell migration
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Golgi apparatus membrane
Inflammasome
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR004020 DAPIN domainDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR033516 CARD8/ASC/NALP1, CARD domainDomainDomain

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
ASC_HUMANMEFV_HUMANBioGRID, HPRD, IntAct, MINT11498534 12054656 12646168 17964261 25006247 details
ASC_HUMANKAP0_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
ASC_HUMANAIM2_HUMANBioGRID, DIP, InnateDB, IntAct, UniProt19158675 19158676 22286270 24237704 24630722 26121674 details
ASC_HUMANNLRC4_HUMANBioGRID, HPRD, UniProt11374873 12646168 details
ASC_HUMANNLRP3_HUMANBioGRID, DIP, HPRD, IntAct, UniProt11786556 15020601 19158675 24630722 28229991 30182366 30653357 32003754 32435622 details
ASC_HUMANPYDC2_HUMANHPRD, UniProt17178784 17339483 details
ASC_HUMANCASP1_HUMANBioGRID, HPRD, IntAct11967258 12019269 12191486 24630722 25605870 26121674 32435622 details
ASC_HUMANASC_HUMANBioGRID, IntAct23209292 24407287 24630722 25006247 25416956 28247911 details
ASC_HUMANEXOC5_HUMANBioGRID, IntAct25416956 details
ASC_HUMANKSYK_HUMANIntAct25605870 details
ASC_HUMANUBP50_HUMANBioGRID28094437 details
ASC_HUMANNLRP1_HUMANHPRD, IntAct17418785 details
ASC_HUMANCASP8_HUMANBioGRID, InnateDB, UniProt12646168 22267217 30182366 details
ASC_HUMANLAMP1_HUMANInnateDB22286270 details
ASC_HUMANSQSTM_HUMANBioGRID, InnateDB22286270 32003754 details
ASC_HUMANRALB_HUMANBioGRID, InnateDB22286270 details
ASC_HUMANBAX_HUMANUniProt14730312 details
ASC_HUMANIKKA_HUMANBioGRID, UniProt12486103 details
ASC_HUMANIKKB_HUMANBioGRID, UniProt12486103 details
ASC_HUMANPYDC1_HUMANUniProt17178784 details
ASC_HUMANPML_HUMANBioGRID, HPIDb24407287 details
ASC_HUMANRIPK1_HUMANBioGRID, IntAct25402006 details
ASC_HUMANPAK1_HUMANBioGRID, IntAct25402006 details
ASC_HUMANNLRC3_HUMANIntAct25277106 details
ASC_HUMANNALP2_HUMANBioGRID15456791 details
ASC_HUMANIF16_HUMANBioGRID26121674 27764250 details
ASC_HUMANBRCA1_HUMANBioGRID26121674 details
ASC_HUMANARI2_HUMANBioGRID29021376 details
ASC_HUMANTRAF6_HUMANBioGRID31034780 details
ASC_HUMANZFP91_HUMANBioGRID30182366 details
ASC_HUMANHIF1A_HUMANBioGRID32883954 details
ASC_HUMANSRF_HUMANHPRD10847592 details
ASC_HUMANNAL12_HUMANHPRD12019269 details
ASC_HUMANPOP1_HUMANHPRD17178784 details