Entity Details

Primary name FYV1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2I7
EntryNameFYV1_HUMAN
FullName1-phosphatidylinositol 3-phosphate 5-kinase
TaxID9606
Evidenceevidence at protein level
Length2098
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesPIKFYVE

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0006612 protein targeting to membrane
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008270 zinc ion binding
GO:0010008 endosome membrane
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016887 ATP hydrolysis activity
GO:0019065 receptor-mediated endocytosis of virus by host cell
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030593 neutrophil chemotaxis
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032288 myelin assembly
GO:0032438 melanosome organization
GO:0034504 protein localization to nucleus
GO:0035556 intracellular signal transduction
GO:0036289 peptidyl-serine autophosphorylation
GO:0042147 retrograde transport, endosome to Golgi
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0052810 1-phosphatidylinositol-5-kinase activity
GO:0090382 phagosome maturation
GO:0090385 phagosome-lysosome fusion
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903100 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1904562 phosphatidylinositol 5-phosphate metabolic process
GO:2000785 regulation of autophagosome assembly

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Early endosome membrane
Endosome membrane
Late endosome membrane

Domains

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DomainNameCategoryType
IPR000306 FYVE zinc fingerDomainDomain
IPR000591 DEP domainDomainDomain
IPR002423 Chaperonin Cpn60/TCP-1 familyFamilyFamily
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, coreDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017455 Zinc finger, FYVE-relatedDomainDomain
IPR027409 GroEL-like apical domain superfamilyFamilyHomologous superfamily
IPR027410 TCP-1-like chaperonin intermediate domain superfamilyFamilyHomologous superfamily
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminalFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037378 PIKfyve, DEP domainDomainDomain
IPR043548 1-phosphatidylinositol-3phosphate-5-kinaseFamilyFamily

Diseases

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