Entity Details

Primary name HCN4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y3Q4
EntryNameHCN4_HUMAN
FullNamePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
TaxID9606
Evidenceevidence at protein level
Length1203
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesHCN4

GO terms

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GOName
GO:0002027 regulation of heart rate
GO:0003161 cardiac conduction system development
GO:0003163 sinoatrial node development
GO:0003254 regulation of membrane depolarization
GO:0005222 intracellular cAMP-activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005886 plasma membrane
GO:0006812 cation transport
GO:0006936 muscle contraction
GO:0008015 blood circulation
GO:0030552 cAMP binding
GO:0031226 intrinsic component of plasma membrane
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0055117 regulation of cardiac muscle contraction
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071805 potassium ion transmembrane transport
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086015 SA node cell action potential
GO:0086041 voltage-gated potassium channel activity involved in SA node cell action potential depolarization
GO:0086046 membrane depolarization during SA node cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098719 sodium ion import across plasma membrane
GO:0098855 HCN channel complex
GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERGFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR013621 Ion transport N-terminalDomainDomain
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018488 Cyclic nucleotide-binding, conserved siteSiteConserved site
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily

Diseases

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