Entity Details

Primary name HYOU1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y4L1
EntryNameHYOU1_HUMAN
FullNameHypoxia up-regulated protein 1
TaxID9606
Evidenceevidence at protein level
Length999
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesHYOU1

GO terms

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GOName
GO:0002931 response to ischemia
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005790 smooth endoplasmic reticulum
GO:0005925 focal adhesion
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0016020 membrane
GO:0016887 ATP hydrolysis activity
GO:0034663 endoplasmic reticulum chaperone complex
GO:0034976 response to endoplasmic reticulum stress
GO:0036498 IRE1-mediated unfolded protein response
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0070062 extracellular exosome
GO:0071456 cellular response to hypoxia
GO:0071682 endocytic vesicle lumen
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Endoplasmic reticulum lumen

Domains

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DomainNameCategoryType
IPR013126 Heat shock protein 70 familyFamilyFamily
IPR018181 Heat shock protein 70, conserved siteSiteConserved site
IPR029047 Heat shock protein 70kD, peptide-binding domain superfamilyFamilyHomologous superfamily
IPR029048 Heat shock protein 70kD, C-terminal domain superfamilyFamilyHomologous superfamily
IPR043129 ATPase, nucleotide binding domainFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
233600 OMIMImmunodeficiency 59 and hypoglycemia (IMD59)An autosomal recessive primary immunologic disorder characterized by combined immunodeficiency, granulocytopenia, B-cell and dendritic cell deficiency, recurrent septic infections of the respiratory tract, skin and mucous membranes, and disturbed glucose metabolism. The disease may be caused by variants affecting the gene represented in this entry.