Entity Details

Primary name DUS10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y6W6
EntryNameDUS10_HUMAN
FullNameDual specificity protein phosphatase 10
TaxID9606
Evidenceevidence at protein level
Length482
SequenceStatuscomplete
DateCreated2002-01-23
DateModified2021-06-02

Ontological Relatives

GenesDUSP10

GO terms

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GOName
GO:0000188 obsolete inactivation of MAPK activity
GO:0002819 regulation of adaptive immune response
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0008330 protein tyrosine/threonine phosphatase activity
GO:0008432 JUN kinase binding
GO:0010633 negative regulation of epithelial cell migration
GO:0016311 dephosphorylation
GO:0016607 nuclear speck
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0030336 negative regulation of cell migration
GO:0032496 response to lipopolysaccharide
GO:0033549 MAP kinase phosphatase activity
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035970 peptidyl-threonine dephosphorylation
GO:0043508 negative regulation of JUN kinase activity
GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0046329 negative regulation of JNK cascade
GO:0048273 mitogen-activated protein kinase p38 binding
GO:0048709 oligodendrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051019 mitogen-activated protein kinase binding
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0090335 regulation of brown fat cell differentiation
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1903753 negative regulation of p38MAPK cascade
GO:1905042 negative regulation of epithelium regeneration
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR001763 Rhodanese-like domainDomainDomain
IPR008343 Mitogen-activated protein (MAP) kinase phosphataseFamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR020422 Dual specificity protein phosphatase domainDomainDomain
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036873 Rhodanese-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
DUS10_HUMANMK14_HUMANBioGRID, HPRD, IntAct10391943 10597297 11157753 11359773 20936779 28675297 details
DUS10_HUMANRS11_HUMANBioGRID, IntAct21988832 details
DUS10_HUMANSNX2_HUMANBioGRID, IntAct21988832 details
DUS10_HUMANFHL2_HUMANBioGRID, IntAct21988832 details
DUS10_HUMANFINC_HUMANBioGRID, IntAct21988832 details
DUS10_HUMANSLX1_HUMANBioGRID, IntAct21988832 details
DUS10_HUMANMK09_HUMANBioGRID, IntAct, MINT11359773 16288922 27880917 28675297 32296183 details
DUS10_HUMANCKLF6_HUMANBioGRID, MINT21900206 details
DUS10_HUMANHD_HUMANBioGRID, IntAct23275563 details
DUS10_HUMANFND3B_HUMANBioGRID, IntAct32296183 details
DUS10_HUMANMK08_HUMANBioGRID, HPRD, IntAct10391943 10597297 16166642 28675297 32296183 details
DUS10_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
DUS10_HUMANKRA32_HUMANBioGRID, IntAct32296183 details
DUS10_HUMANERBB4_HUMANBioGRID, MINT28065597 details
DUS10_HUMANROR2_HUMANBioGRID, MINT28065597 details
DUS10_HUMANIGF1R_HUMANBioGRID, MINT28065597 details
DUS10_HUMANPTK7_HUMANBioGRID, MINT28065597 details
DUS10_HUMANCRYA2_HUMANIntAct32814053 details
DUS10_HUMANDYHC1_HUMANIntAct32814053 details
DUS10_HUMANFGFR3_HUMANIntAct32814053 details
DUS10_HUMANNMDE3_HUMANIntAct32814053 details
DUS10_HUMANGELS_HUMANIntAct32814053 details
DUS10_HUMANRASH_HUMANIntAct32814053 details
DUS10_HUMANBACE2_HUMANIntAct32814053 details
DUS10_HUMANUBQL1_HUMANIntAct32814053 details
DUS10_HUMANMK10_HUMANBioGRID, HPRD11359773 details
DUS10_HUMANMK03_HUMANHPRD10597297 details
DUS10_HUMANMK11_HUMANHPRD11359773 details