Entity Details

Primary name ICOSL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75144
EntryNameICOSL_HUMAN
FullNameICOS ligand
TaxID9606
Evidenceevidence at protein level
Length302
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesICOSLG

GO terms

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GOName
GO:0001817 regulation of cytokine production
GO:0002250 adaptive immune response
GO:0005102 signaling receptor binding
GO:0005886 plasma membrane
GO:0006952 defense response
GO:0006972 hyperosmotic response
GO:0007165 signal transduction
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0031295 T cell costimulation
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042104 positive regulation of activated T cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042802 identical protein binding
GO:0050852 T cell receptor signaling pathway
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ICOSL_HUMANICOS_HUMANBioGRID, HPRD, IntAct10657606 11023515 11956294 16951355 28514442 details
ICOSL_HUMANICOSL_HUMANIntAct16951355 details