Entity Details

Primary name LRP6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75581
EntryNameLRP6_HUMAN
FullNameLow-density lipoprotein receptor-related protein 6
TaxID9606
Evidenceevidence at protein level
Length1613
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesLRP6

GO terms

Show/Hide Table
GOName
GO:0001843 neural tube closure
GO:0001933 negative regulation of protein phosphorylation
GO:0003344 pericardium morphogenesis
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005102 signaling receptor binding
GO:0005109 frizzled binding
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0006469 negative regulation of protein kinase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 chemical synaptic transmission
GO:0009880 embryonic pattern specification
GO:0009986 cell surface
GO:0014029 neural crest formation
GO:0014033 neural crest cell differentiation
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0016055 Wnt signaling pathway
GO:0017147 Wnt-protein binding
GO:0019210 kinase inhibitor activity
GO:0019534 toxin transmembrane transporter activity
GO:0021587 cerebellum morphogenesis
GO:0021794 thalamus development
GO:0021987 cerebral cortex development
GO:0030278 regulation of ossification
GO:0030326 embryonic limb morphogenesis
GO:0030901 midbrain development
GO:0030917 midbrain-hindbrain boundary development
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0034185 apolipoprotein binding
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0035261 external genitalia morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042813 Wnt-activated receptor activity
GO:0043025 neuronal cell body
GO:0043434 response to peptide hormone
GO:0044335 canonical Wnt signaling pathway involved in neural crest cell differentiation
GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045787 positive regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046849 bone remodeling
GO:0048596 embryonic camera-type eye morphogenesis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060021 roof of mouth development
GO:0060026 convergent extension
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060325 face morphogenesis
GO:0060349 bone morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060535 trachea cartilage morphogenesis
GO:0071397 cellular response to cholesterol
GO:0071542 dopaminergic neuron differentiation
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071936 coreceptor activity involved in Wnt signaling pathway
GO:0072659 protein localization to plasma membrane
GO:0090009 primitive streak formation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090245 axis elongation involved in somitogenesis
GO:0098609 cell-cell adhesion
GO:1904886 beta-catenin destruction complex disassembly
GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1990851 Wnt-Frizzled-LRP5/6 complex
GO:1990909 Wnt signalosome

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Endoplasmic reticulum
Membrane raft

Domains

Show/Hide Table
DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000742 EGF-like domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR017049 Low density lipoprotein receptor-related protein 5/6FamilyFamily
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
616724 OMIMTooth agenesis, selective, 7 (STHAG7)An autosomal dominant form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). The disease is caused by variants affecting the gene represented in this entry.
610947 OMIMCoronary artery disease, autosomal dominant, 2 (ADCAD2)A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction. The disease is caused by variants affecting the gene represented in this entry.

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
LRP6_HUMANAXIN1_HUMANBioGRID, DIP, HPRD, IntAct12897152 16890161 19107203 20128690 22682247 23892894 23959799 24976009 28966723 details
LRP6_HUMANWNT3A_HUMANBioGRID, DIP, HPRD, IntAct12897152 14739301 19910923 21944579 22726442 details
LRP6_HUMANLRRK2_HUMANBioGRID, IntAct22899650 27013965 details
LRP6_HUMANAT132_HUMANBioGRID, IntAct22645275 details
LRP6_HUMANGSK3A_HUMANbhf-ucl, BioGRID, UniProt16365045 30824926 details
LRP6_HUMANGSK3B_HUMANbhf-ucl, BioGRID, HPRD16365045 16890161 19107203 details
LRP6_HUMANDKK1_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct11357136 11448771 15035989 21944579 21984209 26186194 27322059 28514442 details
LRP6_HUMANSOST_HUMANbhf-ucl, BioGRID, DIP, IntAct, UniProt15908424 21471202 21944579 28514442 details
LRP6_HUMANLRP6_HUMANbhf-ucl, BioGRID, DIP, HPRD12897152 21984209 28966723 details
LRP6_HUMANCKLF_HUMANBioGRID, IntAct32296183 details
LRP6_HUMANDKK2_HUMANDIP, HPRD11357136 11742004 21944579 details
LRP6_HUMANAPOB_HUMANBioGRID18948618 details
LRP6_HUMANFZD8_HUMANBioGRID, HPRD11029007 11448771 15908424 details
LRP6_HUMANWNT1_HUMANBioGRID, HPRD11029007 11448771 details
LRP6_HUMANPEDF_HUMANBioGRID21576363 details
LRP6_HUMANMK_HUMANBioGRID12573468 details
LRP6_HUMANANTR1_HUMANHPRD, IntAct16564009 details
LRP6_HUMANANTR2_HUMANHPRD, IntAct16564009 details
LRP6_HUMANAMMR1_HUMANMINT21304492 details
LRP6_HUMANDAB2_HUMANMINT22491013 details
LRP6_HUMANCAPR2_HUMANbhf-ucl, BioGRID18762581 details
LRP6_HUMANCAV1_HUMANbhf-ucl, BioGRID16890161 28966723 34079125 details
LRP6_HUMANCTNB1_HUMANbhf-ucl, BioGRID16890161 31262711 details
LRP6_HUMANEEA1_HUMANbhf-ucl16890161 details
LRP6_HUMANRB11A_HUMANbhf-ucl16890161 details
LRP6_HUMANBAMBI_HUMANbhf-ucl18838381 details
LRP6_HUMANIBP4_HUMANDIP18528331 details
LRP6_HUMANPGFRB_HUMANDIP21245321 details
LRP6_HUMANZNRF3_HUMANBioGRID, DIP22575959 details
LRP6_HUMANRIPK4_HUMANDIP23371553 details
LRP6_HUMANNPC1_HUMANBioGRID18948618 details
LRP6_HUMANWNT5A_HUMANBioGRID19910923 details
LRP6_HUMANFZD5_HUMANBioGRID, HPRD12121999 12857724 details
LRP6_HUMANLGR4_HUMANBioGRID24639526 details
LRP6_HUMANIQGA1_HUMANBioGRID24639526 details
LRP6_HUMANEPN1_HUMANBioGRID25871009 details
LRP6_HUMANLRP5_HUMANBioGRID28966723 details
LRP6_HUMANITCH_HUMANBioGRID28966723 details
LRP6_HUMANLMBRL_HUMANBioGRID31073040 details
LRP6_HUMANTRAF6_HUMANBioGRID31262711 details
LRP6_HUMANTLRN1_HUMANHPRD16989816 details