Entity Details

Primary name S22A3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75751
EntryNameS22A3_HUMAN
FullNameSolute carrier family 22 member 3
TaxID9606
Evidenceevidence at protein level
Length556
SequenceStatuscomplete
DateCreated2002-10-19
DateModified2021-06-02

Ontological Relatives

GenesSLC22A3

GO terms

Show/Hide Table
GOName
GO:0001692 histamine metabolic process
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005330 dopamine:sodium symporter activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006836 neurotransmitter transport
GO:0008504 monoamine transmembrane transporter activity
GO:0008514 organic anion transmembrane transporter activity
GO:0015101 organic cation transmembrane transporter activity
GO:0015651 quaternary ammonium group transmembrane transporter activity
GO:0015695 organic cation transport
GO:0015697 quaternary ammonium group transport
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015844 monoamine transport
GO:0016020 membrane
GO:0019534 toxin transmembrane transporter activity
GO:0032098 regulation of appetite
GO:0042908 xenobiotic transport
GO:0043025 neuronal cell body
GO:0051610 serotonin uptake
GO:0051615 histamine uptake
GO:0051620 norepinephrine uptake
GO:0051625 epinephrine uptake
GO:0072530 purine-containing compound transmembrane transport
GO:0090494 dopamine uptake
GO:0098793 presynapse
GO:0150104 transport across blood-brain barrier
GO:1901998 toxin transport

Subcellular Location

Show/Hide Table
Subcellular Location
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR004749 Organic cation transport protein/SVOPFamilyFamily
IPR005829 Sugar transporter, conserved siteSiteConserved site
IPR011701 Major facilitator superfamilyFamilyFamily
IPR020846 Major facilitator superfamily domainDomainDomain
IPR036259 MFS transporter superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00122 CholineDrugbanksmall molecule
DB00182 AmphetamineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00331 MetforminDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00413 PramipexoleDrugbanksmall molecule
DB00448 LansoprazoleDrugbanksmall molecule
DB00457 PrazosinDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00536 GuanidineDrugbanksmall molecule
DB00541 VincristineDrugbanksmall molecule
DB00575 ClonidineDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00718 Adefovir dipivoxilDrugbanksmall molecule
DB00762 IrinotecanDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00925 PhenoxybenzamineDrugbanksmall molecule
DB00938 SalmeterolDrugbanksmall molecule
DB00983 FormoterolDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01035 ProcainamideDrugbanksmall molecule
DB01042 MelphalanSwissprotsmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01577 MetamfetamineDrugbanksmall molecule
DB05381 HistamineDrugbanksmall molecule
DB08837 TetraethylammoniumDrugbanksmall molecule
DB08838 AgmatineDrugbanksmall molecule
DB08841 TyramineSwissprotsmall molecule
DB08882 LinagliptinDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14006 Choline salicylateDrugbanksmall molecule

Interactions

3 interactions