Entity Details

Primary name UFL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO94874
EntryNameUFL1_HUMAN
FullNameE3 UFM1-protein ligase 1
TaxID9606
Evidenceevidence at protein level
Length794
SequenceStatuscomplete
DateCreated2005-06-21
DateModified2021-06-02

Ontological Relatives

GenesUFL1

GO terms

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GOName
GO:0001649 osteoblast differentiation
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008284 positive regulation of cell population proliferation
GO:0010508 positive regulation of autophagy
GO:0016020 membrane
GO:0016570 histone modification
GO:0019901 protein kinase binding
GO:0030218 erythrocyte differentiation
GO:0031397 negative regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880 regulation of protein localization
GO:0032991 protein-containing complex
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034976 response to endoplasmic reticulum stress
GO:0035861 site of double-strand break
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050727 regulation of inflammatory response
GO:0060218 hematopoietic stem cell differentiation
GO:0060252 positive regulation of glial cell proliferation
GO:0061666 UFM1 ligase activity
GO:0061709 reticulophagy
GO:0071568 UFM1 transferase activity
GO:0071569 protein ufmylation
GO:1902065 response to L-glutamate
GO:1903895 negative regulation of IRE1-mediated unfolded protein response
GO:1990592 protein K69-linked ufmylation

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR018611 E3 UFM1-protein ligase 1FamilyFamily

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
UFL1_HUMANCK5P3_HUMANBioGRID, IntAct17353931 20164180 28514442 32296183 32807901 details
UFL1_HUMANUB2D1_HUMANIntAct19690564 details
UFL1_HUMANUB2D2_HUMANIntAct19690564 details
UFL1_HUMANUB2D3_HUMANIntAct19690564 details
UFL1_HUMANUB2D4_HUMANIntAct19690564 details
UFL1_HUMANUB2E1_HUMANIntAct19690564 details
UFL1_HUMANUB2E3_HUMANIntAct19690564 details
UFL1_HUMANUBE2W_HUMANIntAct19690564 details
UFL1_HUMANDDRGK_HUMANBioGRID, IntAct26186194 28514442 32160526 32545848 32807901 details
UFL1_HUMANFIBB_HUMANBioGRID32545848 details
UFL1_HUMANENY2_HUMANBioGRID32545848 details
UFL1_HUMANTIPRL_HUMANBioGRID32545848 details
UFL1_HUMANPTPRO_HUMANBioGRID32545848 details
UFL1_HUMANIKBP1_HUMANBioGRID32545848 details
UFL1_HUMANATP4A_HUMANBioGRID32545848 details
UFL1_HUMANHINFP_HUMANBioGRID32545848 details
UFL1_HUMANSAHH_HUMANBioGRID32545848 details
UFL1_HUMANAK17A_HUMANBioGRID32545848 details
UFL1_HUMANIRF3_HUMANBioGRID32545848 details
UFL1_HUMANH2A1B_HUMANBioGRID32545848 details
UFL1_HUMANZN219_HUMANBioGRID32545848 details
UFL1_HUMANT22D3_HUMANBioGRID32545848 details
UFL1_HUMANPPIL1_HUMANBioGRID32545848 details
UFL1_HUMANMT1M_HUMANBioGRID32545848 details
UFL1_HUMANUFC1_HUMANBioGRID32545848 32807901 details
UFL1_HUMANP53_HUMANBioGRID32807901 details
UFL1_HUMANPHLA3_HUMANIntAct17353931 details
UFL1_HUMANTP4A3_HUMANIntAct17353931 details
UFL1_HUMANGSTK1_HUMANIntAct17353931 details
UFL1_HUMANFMR1_HUMANBioGRID, IntAct31413325 32807901 details
UFL1_HUMANABCE1_HUMANBioGRID25659154 details