Entity Details

Primary name TRI37_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO94972
EntryNameTRI37_HUMAN
FullNameE3 ubiquitin-protein ligase TRIM37
TaxID9606
Evidenceevidence at protein level
Length964
SequenceStatuscomplete
DateCreated2004-11-23
DateModified2021-06-02

Ontological Relatives

GenesTRIM37

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0008270 zinc ion binding
GO:0016235 aggresome
GO:0031625 ubiquitin protein ligase binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0035518 histone H2A monoubiquitination
GO:0036353 histone H2A-K119 monoubiquitination
GO:0042803 protein homodimerization activity
GO:0046600 negative regulation of centriole replication
GO:0048471 perinuclear region of cytoplasm
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070842 aggresome assembly

Subcellular Location

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Subcellular Location
Cytoplasm
Peroxisome

Domains

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DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR002083 MATH/TRAF domainDomainDomain
IPR003649 B-box, C-terminalDomainDomain
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR037299 TRIM37, MATH domainDomainDomain

Diseases

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Disease IDSourceNameDescription
253250 OMIMMulibrey nanism (MUL)An autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms' tumor. The disease is caused by variants affecting the gene represented in this entry.

Interactions

94 interactions

InteractorPartnerSourcesPublicationsLink
TRI37_HUMANPRC1_HUMANBioGRID, HPRD, IntAct16189514 19447967 details
TRI37_HUMANF124B_HUMANBioGRID, HPRD, IntAct16189514 19447967 details
TRI37_HUMANMAGBI_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANELOA2_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANAPEX2_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANFXR2_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANF107A_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
TRI37_HUMANRIBC2_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANRHPN1_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANBYST_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
TRI37_HUMANZN655_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANDLGP5_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANPNKP_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
TRI37_HUMANCOPB_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
TRI37_HUMANK0408_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANZN417_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
TRI37_HUMANMCM10_HUMANBioGRID, HPRD, IntAct16189514 19447967 details
TRI37_HUMANEWS_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANMCRS1_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
TRI37_HUMANNUD18_HUMANBioGRID, HPRD, IntAct16189514 details
TRI37_HUMANTOPK_HUMANBioGRID, HPRD, IntAct16189514 32908313 details
TRI37_HUMANAPTX_HUMANBioGRID, HPRD, IntAct16713569 details
TRI37_HUMANUBE2U_HUMANBioGRID, IntAct19690564 details
TRI37_HUMANCCD33_HUMANBioGRID, IntAct19447967 details
TRI37_HUMANUBE2H_HUMANBioGRID, IntAct19549727 details
TRI37_HUMANCK5P2_HUMANBioGRID, IntAct21988832 details
TRI37_HUMANC19L2_HUMANBioGRID, IntAct25416956 32296183 details
TRI37_HUMANDDX6_HUMANBioGRID, IntAct25416956 details
TRI37_HUMANRL9_HUMANBioGRID, IntAct25416956 33194618 details
TRI37_HUMANUBS3A_HUMANBioGRID, IntAct25416956 details
TRI37_HUMANF161A_HUMANBioGRID, IntAct25416956 details
TRI37_HUMANZN329_HUMANBioGRID, IntAct25416956 details
TRI37_HUMANCD20B_HUMANBioGRID, IntAct25416956 32296183 details
TRI37_HUMANKAT5_HUMANBioGRID, IntAct25416956 details
TRI37_HUMANZMAT2_HUMANBioGRID, IntAct25416956 details
TRI37_HUMANSCNM1_HUMANBioGRID, IntAct25416956 details
TRI37_HUMANFA50B_HUMANBioGRID, IntAct25416956 details
TRI37_HUMANRASD1_HUMANBioGRID, IntAct25416956 details
TRI37_HUMANADIP_HUMANBioGRID, IntAct25416956 26638075 details
TRI37_HUMANAXIN1_HUMANBioGRID, IntAct26871637 details
TRI37_HUMANRXRB_HUMANBioGRID, IntAct26871637 details
TRI37_HUMANTEANC_HUMANBioGRID, IntAct32296183 details
TRI37_HUMANCDKL3_HUMANBioGRID, IntAct32296183 details
TRI37_HUMANZBT24_HUMANBioGRID, IntAct32296183 details
TRI37_HUMANAQP1_HUMANBioGRID, IntAct32296183 details
TRI37_HUMANELOA1_HUMANBioGRID, IntAct32296183 details
TRI37_HUMANSYTL4_HUMANBioGRID, IntAct32296183 details
TRI37_HUMANCDC7_HUMANBioGRID, IntAct32296183 details
TRI37_HUMANDZI1L_HUMANBioGRID, IntAct32296183 details
TRI37_HUMANZN587_HUMANBioGRID, IntAct32296183 details
TRI37_HUMANDTNB_HUMANBioGRID, IntAct32296183 details
TRI37_HUMANTRAF1_HUMANBioGRID, HPRD11279055 details
TRI37_HUMANTRAF2_HUMANBioGRID, HPRD11279055 30043491 details
TRI37_HUMANTRAF3_HUMANBioGRID, HPRD11279055 details
TRI37_HUMANTRAF4_HUMANBioGRID, HPRD11279055 details
TRI37_HUMANTRAF5_HUMANBioGRID, HPRD11279055 details
TRI37_HUMANTRAF6_HUMANBioGRID, HPRD11279055 30254148 details
TRI37_HUMANTRI37_HUMANBioGRID11279055 32908313 details
TRI37_HUMANTNR1B_HUMANBioGRID11279055 details
TRI37_HUMANTNR3_HUMANBioGRID11279055 details
TRI37_HUMANTNR16_HUMANBioGRID11279055 details
TRI37_HUMANUB2D1_HUMANBioGRID21143188 details
TRI37_HUMANUB2D2_HUMANBioGRID21143188 30254148 details
TRI37_HUMANUB2D3_HUMANBioGRID21143188 details
TRI37_HUMANUB2E1_HUMANBioGRID21143188 details
TRI37_HUMANUB2E2_HUMANBioGRID21143188 details
TRI37_HUMANUB2E3_HUMANBioGRID21143188 details
TRI37_HUMANANR11_HUMANBioGRID24722188 details
TRI37_HUMANARNT2_HUMANBioGRID24722188 details
TRI37_HUMANKIF9_HUMANBioGRID25416956 details
TRI37_HUMANH2A2C_HUMANBioGRID25470042 details
TRI37_HUMANH2A1B_HUMANBioGRID27832544 33194618 details
TRI37_HUMANPEX5_HUMANBioGRID28724525 details
TRI37_HUMANRNF6_HUMANBioGRID26871637 details
TRI37_HUMANNEMO_HUMANBioGRID30254148 details
TRI37_HUMANUBB_HUMANHPRD15885686 details
TRI37_HUMANHS90B_HUMANBioGRID, IntAct22939624 33194618 details
TRI37_HUMANEPHA4_HUMANIntAct31413325 details
TRI37_HUMANDISC1_HUMANIntAct31413325 details
TRI37_HUMANHS90A_HUMANBioGRID22939624 33194618 details
TRI37_HUMANCE192_HUMANBioGRID24613305 32908313 details
TRI37_HUMANEZH2_HUMANBioGRID25470042 details
TRI37_HUMANSUZ12_HUMANBioGRID25470042 details
TRI37_HUMANBMI1_HUMANBioGRID25470042 details
TRI37_HUMANH31T_HUMANBioGRID25470042 details
TRI37_HUMANCTNB1_HUMANBioGRID26395261 details
TRI37_HUMANATM_HUMANBioGRID30254148 details
TRI37_HUMANMTOR_HUMANBioGRID29940807 details
TRI37_HUMANRRAGB_HUMANBioGRID29940807 details
TRI37_HUMANPPARG_HUMANBioGRID31301768 details
TRI37_HUMANLZTS2_HUMANBioGRID29395067 32908313 details
TRI37_HUMANTNR6B_HUMANBioGRID29395067 32908313 details
TRI37_HUMANDUS6_HUMANBioGRID32606764 details
TRI37_HUMANSMAD7_HUMANBioGRID32916597 details