Entity Details

Primary name NKX22_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95096
EntryNameNKX22_HUMAN
FullNameHomeobox protein Nkx-2.2
TaxID9606
Evidenceevidence at transcript level
Length273
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesNKX2-2

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003323 type B pancreatic cell development
GO:0003326 pancreatic A cell fate commitment
GO:0003327 type B pancreatic cell fate commitment
GO:0003329 pancreatic PP cell fate commitment
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007224 smoothened signaling pathway
GO:0007420 brain development
GO:0008134 transcription factor binding
GO:0009749 response to glucose
GO:0010628 positive regulation of gene expression
GO:0014003 oligodendrocyte development
GO:0021522 spinal cord motor neuron differentiation
GO:0021530 spinal cord oligodendrocyte cell fate specification
GO:0021554 optic nerve development
GO:0030154 cell differentiation
GO:0031018 endocrine pancreas development
GO:0032570 response to progesterone
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0048565 digestive tract development
GO:0048665 neuron fate specification
GO:0048708 astrocyte differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0060580 ventral spinal cord interneuron fate determination

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain

Diseases

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Interactions

3 interactions