Entity Details

Primary name PARN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95453
EntryNamePARN_HUMAN
FullNamePoly(A)-specific ribonuclease PARN
TaxID9606
Evidenceevidence at protein level
Length639
SequenceStatuscomplete
DateCreated2005-03-01
DateModified2021-06-02

Ontological Relatives

GenesPARN

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000495 box H/ACA RNA 3'-end processing
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0004518 nuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007292 female gamete generation
GO:0009451 RNA modification
GO:0010587 miRNA catabolic process
GO:0016607 nuclear speck
GO:0019901 protein kinase binding
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0043169 cation binding
GO:0043488 regulation of mRNA stability
GO:0046872 metal ion binding
GO:0051973 positive regulation of telomerase activity
GO:0070034 telomerase RNA binding
GO:0071051 polyadenylation-dependent snoRNA 3'-end processing
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:0090669 telomerase RNA stabilization
GO:0110008 ncRNA deadenylation
GO:1904872 regulation of telomerase RNA localization to Cajal body

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001374 R3H domainDomainDomain
IPR006941 Ribonuclease CAF1FamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR014789 Poly(A)-specific ribonuclease, RNA-bindingDomainDomain
IPR034042 PARN, R3H domainDomainDomain
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR036867 R3H domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
PARN_HUMANMPH6_HUMANHPRD, IntAct15231747 details
PARN_HUMANSPC1L_HUMANBioGRID, HPRD, IntAct15231747 details
PARN_HUMANBARD1_HUMANBioGRID, MINT20379136 details
PARN_HUMANNCBP1_HUMANMINT20379136 details
PARN_HUMANMAPK2_HUMANBioGRID20932473 details
PARN_HUMANPALS2_HUMANBioGRID15231747 details
PARN_HUMANSUMO2_HUMANBioGRID19394292 details
PARN_HUMANCSTF2_HUMANBioGRID, MINT20379136 details
PARN_HUMANPABP1_HUMANIntAct17595167 details
PARN_HUMANZCCHV_HUMANDIP21876179 details
PARN_HUMANFUBP2_HUMANBioGRID, HPRD15175153 details
PARN_HUMANRENT1_HUMANBioGRID14527413 details
PARN_HUMANRENT2_HUMANBioGRID14527413 details
PARN_HUMANREN3A_HUMANBioGRID14527413 details
PARN_HUMANCSTF1_HUMANBioGRID20379136 details
PARN_HUMANPARN_HUMANBioGRID20379136 details
PARN_HUMANNXF1_HUMANBioGRID29395067 details
PARN_HUMANFANCI_HUMANBioGRID29395067 details
PARN_HUMANJHD2C_HUMANBioGRID29395067 details
PARN_HUMANGWL_HUMANBioGRID29395067 details
PARN_HUMANNCOR1_HUMANBioGRID29395067 details
PARN_HUMANRS15A_HUMANBioGRID29395067 details
PARN_HUMANRRP12_HUMANBioGRID29395067 details
PARN_HUMANSIR1_HUMANBioGRID29395067 details
PARN_HUMANUT14A_HUMANBioGRID29395067 details
PARN_HUMANYETS2_HUMANBioGRID29395067 details
PARN_HUMANSMG7_HUMANBioGRID29395067 details
PARN_HUMANBCOR_HUMANBioGRID29395067 details
PARN_HUMANDACH1_HUMANBioGRID29395067 details
PARN_HUMANESS2_HUMANBioGRID29395067 details
PARN_HUMANZBT21_HUMANBioGRID29395067 details
PARN_HUMANZSC18_HUMANBioGRID29395067 details
PARN_HUMANCSTF3_HUMANBioGRID29395067 details
PARN_HUMANBRE1B_HUMANBioGRID29395067 details
PARN_HUMANF207A_HUMANBioGRID29395067 details
PARN_HUMANH31_HUMANBioGRID29395067 details
PARN_HUMANNCOR2_HUMANBioGRID29395067 details
PARN_HUMANNFIC_HUMANBioGRID29395067 details
PARN_HUMANRBM5_HUMANBioGRID29395067 details
PARN_HUMANNADAP_HUMANBioGRID29395067 details
PARN_HUMANTRPS1_HUMANBioGRID29395067 details
PARN_HUMANSHLD2_HUMANBioGRID30154076 details