Entity Details

Primary name HERC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95714
EntryNameHERC2_HUMAN
FullNameE3 ubiquitin-protein ligase HERC2
TaxID9606
Evidenceevidence at protein level
Length4834
SequenceStatuscomplete
DateCreated2006-04-04
DateModified2021-06-02

Ontological Relatives

GenesHERC2

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006886 intracellular protein transport
GO:0006974 cellular response to DNA damage stimulus
GO:0008270 zinc ion binding
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032183 SUMO binding
GO:0061630 ubiquitin protein ligase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000408 Regulator of chromosome condensation, RCC1RepeatRepeat
IPR000433 Zinc finger, ZZ-typeDomainDomain
IPR000569 HECT domainDomainDomain
IPR001199 Cytochrome b5-like heme/steroid binding domainDomainDomain
IPR004939 APC10/DOC domainDomainDomain
IPR006624 Beta-propeller repeat TECPRRepeatRepeat
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein IIFamilyHomologous superfamily
IPR010606 Mib-herc2DomainDomain
IPR014722 Ribosomal protein L2, domain 2FamilyHomologous superfamily
IPR021097 CPH domainDomainDomain
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036400 Cytochrome b5-like heme/steroid binding domain superfamilyFamilyHomologous superfamily
IPR037252 Mib/herc2 domain superfamilyFamilyHomologous superfamily
IPR037976 HERC2, APC10 domainDomainDomain
IPR041987 HERC2, zinc finger, ZZ-typeDomainDomain
IPR043145 Zinc finger, ZZ-type superfamilyFamilyHomologous superfamily

Diseases

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Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
HERC2_HUMANDISC1_HUMANIntAct17043677 31413325 details
HERC2_HUMANUBP20_HUMANBioGRID, IntAct19615732 25326330 25355518 25476789 29426014 30279242 details
HERC2_HUMANCDC42_HUMANBioGRID, IntAct20936779 details
HERC2_HUMANP53_HUMANBioGRID, MINT22653443 24722987 27259994 28977907 31665549 details
HERC2_HUMANNCOA4_HUMANBioGRID, IntAct25476789 26436293 28514442 29426014 30279242 details
HERC2_HUMANXPA_HUMANBioGRID, DIP20304803 23178497 details
HERC2_HUMANRNF8_HUMANBioGRID, DIP20023648 22508508 22814251 25305019 26503038 details
HERC2_HUMANC5AR2_HUMANBioGRID, MINT28298427 details
HERC2_HUMANBKRB2_HUMANBioGRID, MINT28298427 details
HERC2_HUMANBRCA1_HUMANBioGRID20631078 25480944 30279242 details
HERC2_HUMANUBE2N_HUMANBioGRID20023648 27259994 details
HERC2_HUMANCALM1_HUMANBioGRID15840729 details
HERC2_HUMANCALM2_HUMANBioGRID15840729 details
HERC2_HUMANCALM3_HUMANBioGRID15840729 details
HERC2_HUMANUBC_HUMANBioGRID22508508 28190767 details
HERC2_HUMANHERC2_HUMANBioGRID22496338 26949039 31582797 details
HERC2_HUMANUB2D3_HUMANBioGRID20631078 details
HERC2_HUMANSTK11_HUMANBioGRID27259994 details
HERC2_HUMANUB2D1_HUMANBioGRID27259994 details
HERC2_HUMANERG_HUMANBioGRID27626314 details
HERC2_HUMANUB2L3_HUMANBioGRID29643511 details
HERC2_HUMANUB2D2_HUMANBioGRID29643511 details
HERC2_HUMANRNF11_HUMANHPRD15231748 details
HERC2_HUMANUBP16_HUMANBioGRID, IntAct19615732 25305019 28514442 30279242 details
HERC2_HUMANKI20A_HUMANBioGRID, IntAct25476789 26496610 details
HERC2_HUMANFBXL5_HUMANBioGRID, IntAct24778179 28514442 30279242 details
HERC2_HUMANNEUL4_HUMANBioGRID, IntAct22261722 25476789 28977907 29426014 29511261 30279242 31665549 details
HERC2_HUMANEME1_HUMANBioGRID, IntAct25476789 29426014 details
HERC2_HUMANFRIH_HUMANBioGRID, IntAct25476789 29426014 details
HERC2_HUMANFRIL_HUMANBioGRID, IntAct25476789 29426014 details
HERC2_HUMANNUDC2_HUMANBioGRID, IntAct25476789 29426014 31427565 details
HERC2_HUMANUBE3A_HUMANBioGRID, IntAct21493713 22645313 25476789 29426014 30257870 30279242 details
HERC2_HUMANKPBB_HUMANBioGRID, IntAct25476789 29426014 details
HERC2_HUMANEIF3M_HUMANBioGRID, IntAct25476789 29426014 30279242 details
HERC2_HUMANEIF3E_HUMANBioGRID, IntAct25476789 29426014 30279242 details
HERC2_HUMANPHKG2_HUMANBioGRID, IntAct25476789 29426014 details
HERC2_HUMANEIF3H_HUMANBioGRID, IntAct25476789 29426014 30279242 details
HERC2_HUMANPMS1_HUMANBioGRID17148452 details
HERC2_HUMANMDC1_HUMANBioGRID20023648 details
HERC2_HUMANRN168_HUMANBioGRID20023648 details
HERC2_HUMANPIAS4_HUMANBioGRID22508508 details
HERC2_HUMANATRIP_HUMANBioGRID21775519 details
HERC2_HUMANCLSPN_HUMANBioGRID21775519 25326330 details
HERC2_HUMANRFA3_HUMANBioGRID22261722 30279242 details
HERC2_HUMANRFA1_HUMANBioGRID22261722 26474068 30279242 31582797 details
HERC2_HUMANPSDE_HUMANBioGRID24743594 details
HERC2_HUMANMUS81_HUMANBioGRID25476789 details
HERC2_HUMANFDFT_HUMANBioGRID25476789 details
HERC2_HUMANHLAA_HUMANBioGRID25476789 details
HERC2_HUMANHM13_HUMANBioGRID25476789 details
HERC2_HUMANBICD2_HUMANBioGRID25476789 28718761 details
HERC2_HUMANZFYV9_HUMANBioGRID25476789 details
HERC2_HUMANCPT1A_HUMANBioGRID25476789 details
HERC2_HUMANAURKB_HUMANBioGRID25476789 details
HERC2_HUMANDAA10_HUMANBioGRID25476789 details
HERC2_HUMANCOPZ1_HUMANBioGRID25476789 details
HERC2_HUMANCOPE_HUMANBioGRID25476789 details
HERC2_HUMANKAP3_HUMANBioGRID25476789 details
HERC2_HUMANNPRL2_HUMANBioGRID25480944 details
HERC2_HUMANLRRK2_HUMANBioGRID26355680 details
HERC2_HUMANATOH1_HUMANBioGRID27542412 details
HERC2_HUMANSIR1_HUMANBioGRID27259994 details
HERC2_HUMANBLM_HUMANBioGRID30279242 details
HERC2_HUMANTOP3A_HUMANBioGRID30279242 details
HERC2_HUMANRMI2_HUMANBioGRID30279242 details
HERC2_HUMANRFA2_HUMANBioGRID30279242 31582797 details
HERC2_HUMANWRN_HUMANBioGRID30279242 details
HERC2_HUMANBARD1_HUMANBioGRID30279242 details
HERC2_HUMANUBP33_HUMANBioGRID31427565 details
HERC2_HUMANMDM2_HUMANBioGRID31665549 details