Entity Details

Primary name CHK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO96017
EntryNameCHK2_HUMAN
FullNameSerine/threonine-protein kinase Chk2
TaxID9606
Evidenceevidence at protein level
Length543
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesCHEK2

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000086 G2/M transition of mitotic cell cycle
GO:0001934 positive regulation of protein phosphorylation
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0006302 double-strand break repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035690 cellular response to drug
GO:0042176 regulation of protein catabolic process
GO:0042770 signal transduction in response to DNA damage
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044257 cellular protein catabolic process
GO:0044773 mitotic DNA damage checkpoint signaling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0050821 protein stabilization
GO:0051301 cell division
GO:0071480 cellular response to gamma radiation
GO:0090307 mitotic spindle assembly
GO:0090399 replicative senescence
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903416 response to glycoside
GO:1903926 cellular response to bisphenol A
GO:2000002 negative regulation of DNA damage checkpoint
GO:2000210 positive regulation of anoikis

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000253 Forkhead-associated (FHA) domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05149 XL844Drugbanksmall molecule
DB06486 EnzastaurinDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

108 interactions

InteractorPartnerSourcesPublicationsLink
CHK2_HUMANMPIP1_HUMANBioGRID, HPRD, MINT10724175 11298456 12676583 12759351 18480045 details
CHK2_HUMANP53_HUMANBioGRID, HPRD, MINT10673501 10710310 10724175 12810724 12897801 15862297 17157788 18833288 details
CHK2_HUMANNBN_HUMANHPRD, MINT11438675 details
CHK2_HUMANMDM2_HUMANBioGRID, HPRD, MINT15862297 16943424 19176998 details
CHK2_HUMANIMA1_HUMANBioGRID, HPRD, IntAct, MINT12909615 23178491 details
CHK2_HUMANCHK2_HUMANBioGRID, MINT11438675 11901158 12024051 12676583 12909615 16794575 18239682 23178491 25361978 details
CHK2_HUMANAATF_HUMANBioGRID, HPRD, IntAct17157788 details
CHK2_HUMANPLK1_HUMANBioGRID, DIP, HPRD, IntAct10973490 11901158 12024051 12242661 12493754 20126263 details
CHK2_HUMANBRCA1_HUMANBioGRID, HPRD, IntAct10724175 12049740 12111733 12438214 17380128 17525332 18804494 26121674 details
CHK2_HUMANRB_HUMANBioGRID, MINT17380128 details
CHK2_HUMAN2A5E_HUMANBioGRID, HPRD, IntAct15380617 details
CHK2_HUMAN2A5A_HUMANBioGRID, HPRD, IntAct15380617 details
CHK2_HUMAN2A5B_HUMANBioGRID, HPRD, IntAct15380617 details
CHK2_HUMAN2A5G_HUMANBioGRID, HPRD, IntAct15380617 23178491 details
CHK2_HUMAN2A5D_HUMANBioGRID, HPRD, IntAct15380617 details
CHK2_HUMANSTRAP_HUMANBioGRID, MINT18833288 details
CHK2_HUMANXRCC1_HUMANMINT18971944 details
CHK2_HUMANRHG01_HUMANBioGRID, IntAct21988832 details
CHK2_HUMANRPAB5_HUMANBioGRID, IntAct21988832 details
CHK2_HUMANNR4A1_HUMANBioGRID, IntAct21988832 details
CHK2_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
CHK2_HUMANGNAS2_HUMANBioGRID, MINT25640309 details
CHK2_HUMANBAALC_HUMANBioGRID, MINT25640309 details
CHK2_HUMANENOA_HUMANBioGRID, MINT25640309 details
CHK2_HUMANSTMN1_HUMANBioGRID, MINT25640309 details
CHK2_HUMANHMGN1_HUMANBioGRID, MINT25640309 details
CHK2_HUMANADT3_HUMANBioGRID, MINT25640309 details
CHK2_HUMANANM2_HUMANBioGRID, MINT25640309 details
CHK2_HUMANTLR3_HUMANBioGRID, MINT25640309 details
CHK2_HUMANBEX1_HUMANBioGRID, MINT25640309 details
CHK2_HUMANCCL5_HUMANBioGRID, MINT25640309 details
CHK2_HUMANCAD13_HUMANBioGRID, MINT25640309 details
CHK2_HUMANCP17A_HUMANBioGRID, MINT25640309 details
CHK2_HUMANDIRA3_HUMANBioGRID, MINT25640309 details
CHK2_HUMANLRAT2_HUMANBioGRID, MINT25640309 details
CHK2_HUMANHXC6_HUMANBioGRID, MINT25640309 details
CHK2_HUMANIL24_HUMANBioGRID, MINT25640309 details
CHK2_HUMANITIH5_HUMANBioGRID, MINT25640309 details
CHK2_HUMANKLK9_HUMANBioGRID, MINT25640309 details
CHK2_HUMANKLK7_HUMANBioGRID, MINT25640309 details
CHK2_HUMANLYPD3_HUMANBioGRID, MINT25640309 details
CHK2_HUMANPRD14_HUMANBioGRID, MINT25640309 details
CHK2_HUMANHOP2_HUMANBioGRID, MINT25640309 details
CHK2_HUMANRHBT2_HUMANBioGRID, MINT25640309 details
CHK2_HUMANBRE1A_HUMANBioGRID, MINT25640309 details
CHK2_HUMANST14_HUMANBioGRID, MINT25640309 details
CHK2_HUMANNSD3_HUMANBioGRID, MINT25640309 details
CHK2_HUMANCD11A_HUMANIntAct23178491 details
CHK2_HUMANPP2AA_HUMANBioGRID, IntAct15380617 16596250 23178491 26083323 details
CHK2_HUMANRNF8_HUMANBioGRID, DIP22266820 details
CHK2_HUMANMSH2_HUMANBioGRID, HPRD12447371 15647386 details
CHK2_HUMANMDC1_HUMANBioGRID, HPRD12475977 12551934 12607004 details
CHK2_HUMANPLK3_HUMANBioGRID, HPRD10973490 11901158 12242661 12493754 12548019 details
CHK2_HUMANBRCA2_HUMANBioGRID14623252 17525332 18317453 details
CHK2_HUMANMUS81_HUMANBioGRID, HPRD11073977 11741546 details
CHK2_HUMANMDM4_HUMANBioGRID, HPRD16163388 details
CHK2_HUMANFOXM1_HUMANBioGRID17101782 details
CHK2_HUMANATR_HUMANBioGRID, HPRD10973490 11715017 12024051 12493754 17035231 9857181 details
CHK2_HUMANMPIP3_HUMANBioGRID, HPRD10557092 10744722 11053450 11333986 11438675 11551930 12024051 12402044 12897801 12909615 16311512 16705183 25361978 28094252 9278512 details
CHK2_HUMANREV3L_HUMANBioGRID18622427 details
CHK2_HUMANATM_HUMANBioGRID, HPRD10713094 10744722 10973490 11901158 12024051 12242661 12493754 15064416 15790808 16794575 20010693 details
CHK2_HUMAN2ABB_HUMANBioGRID, HPRD15380617 16596250 details
CHK2_HUMANELAV1_HUMANBioGRID17317627 19322201 details
CHK2_HUMANPSME3_HUMANBioGRID19556897 25361978 details
CHK2_HUMANLATS2_HUMANBioGRID21118956 details
CHK2_HUMANPML_HUMANBioGRID12402044 details
CHK2_HUMANDAPK3_HUMANBioGRID15001356 details
CHK2_HUMANA4_HUMANBioGRID21832049 details
CHK2_HUMANZN363_HUMANBioGRID23449389 details
CHK2_HUMANVHL_HUMANBioGRID22071692 details
CHK2_HUMANPRKDC_HUMANBioGRID10713094 17171639 details
CHK2_HUMANGNAS3_HUMANBioGRID25640309 details
CHK2_HUMANALEX_HUMANBioGRID25640309 details
CHK2_HUMANGNAS1_HUMANBioGRID25640309 details
CHK2_HUMANSRPK2_HUMANBioGRID26167880 details
CHK2_HUMANSIAH2_HUMANBioGRID26751770 details
CHK2_HUMANNFKB1_HUMANBioGRID21466675 details
CHK2_HUMANPPM1D_HUMANBioGRID16311512 28027003 details
CHK2_HUMANCDN1A_HUMANBioGRID12897801 details
CHK2_HUMANFHL1_HUMANBioGRID28094252 details
CHK2_HUMANFHL3_HUMANBioGRID28094252 details
CHK2_HUMANCD11B_HUMANBioGRID23178491 details
CHK2_HUMANTAU_HUMANBioGRID20159774 details
CHK2_HUMANSNUT2_HUMANBioGRID30771428 details
CHK2_HUMAN2ABA_HUMANHPRD15380617 details
CHK2_HUMANDBF4A_HUMANHPRD12441400 details
CHK2_HUMANMRC1_HUMANHPRD11715017 details
CHK2_HUMANTERA_HUMANBioGRID, IntAct17525332 29599191 details
CHK2_HUMANPSF2_HUMANBioGRID, IntAct17525332 details
CHK2_HUMANPER3_HUMANBioGRID, MINT21070773 details
CHK2_HUMAN2AAA_HUMANBioGRID, IntAct15380617 23178491 details
CHK2_HUMANTIF1B_HUMANBioGRID22496453 details
CHK2_HUMANKAT2B_HUMANBioGRID19176998 details
CHK2_HUMANUBR5_HUMANBioGRID17074762 details
CHK2_HUMANCUL4A_HUMANBioGRID23109433 details
CHK2_HUMANCUL1_HUMANBioGRID23109433 details
CHK2_HUMANSIR1_HUMANBioGRID25361978 details
CHK2_HUMANCCAR2_HUMANBioGRID25361978 details
CHK2_HUMANCNTN2_HUMANBioGRID15107832 details
CHK2_HUMANFHL2_HUMANBioGRID28094252 details
CHK2_HUMANRBTN1_HUMANBioGRID28094252 details
CHK2_HUMANRBTN2_HUMANBioGRID28094252 details
CHK2_HUMANLMO3_HUMANBioGRID28094252 details
CHK2_HUMANE2F1_HUMANHPRD12717439 details
CHK2_HUMANRAD9A_HUMANHPRD12049741 details
CHK2_HUMANTSSK1_HUMANHPRD12556502 details
CHK2_HUMANASF1A_HUMANHPRD11172707 details
CHK2_HUMANERCC6_HUMANHPRD9450932 details