Entity Details

Primary name RASK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01116
EntryNameRASK_HUMAN
FullNameGTPase KRas
TaxID9606
Evidenceevidence at protein level
Length189
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesKRAS

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000165 MAPK cascade
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007265 Ras protein signal transduction
GO:0007565 female pregnancy
GO:0008284 positive regulation of cell population proliferation
GO:0008542 visual learning
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0019002 GMP binding
GO:0019003 GDP binding
GO:0019221 cytokine-mediated signaling pathway
GO:0021897 forebrain astrocyte development
GO:0030036 actin cytoskeleton organization
GO:0030275 LRR domain binding
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031647 regulation of protein stability
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0035022 positive regulation of Rac protein signal transduction
GO:0035900 response to isolation stress
GO:0038002 endocrine signaling
GO:0042802 identical protein binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045596 negative regulation of cell differentiation
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048873 homeostasis of number of cells within a tissue
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051384 response to glucocorticoid
GO:0051385 response to mineralocorticoid
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:2000774 positive regulation of cellular senescence

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR020849 Small GTPase, Ras-typeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07771 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACIDDrugbanksmall molecule
DB07780 Farnesyl diphosphateDrugbanksmall molecule
DB15568 MRTX849Drugbanksmall molecule
DB15569 AMG-510Drugbanksmall molecule

Interactions

85 interactions

InteractorPartnerSourcesPublicationsLink
RASK_HUMANHNRPC_HUMANBioGRID, HPRD, IntAct16189514 27684187 details
RASK_HUMANRASF2_HUMANBioGRID, HPRD, UniProt12732644 details
RASK_HUMANRAF1_HUMANBioGRID, DIP, HPRD, I2D, IntAct10783161 10882715 10958680 15192046 16041367 16093354 19029954 20080631 20802526 23153539 25852190 26721396 27684187 28205554 30194290 31980649 34079125 8307946 9446616 9564038 details
RASK_HUMANADH6_HUMANBioGRID, IntAct21988832 details
RASK_HUMANLPAR1_HUMANBioGRID, IntAct21988832 details
RASK_HUMANP85B_HUMANBioGRID, IntAct21988832 34079125 details
RASK_HUMANDDX47_HUMANBioGRID, IntAct21988832 details
RASK_HUMANEGLN1_HUMANBioGRID, IntAct21988832 details
RASK_HUMANDDX50_HUMANBioGRID, IntAct21988832 details
RASK_HUMANRGL2_HUMANBioGRID, IntAct21988832 details
RASK_HUMANGNDS_HUMANBioGRID, HPRD, IntAct10783161 21988832 7809086 details
RASK_HUMANDEAF1_HUMANMINT21900206 details
RASK_HUMANTCPH_HUMANBioGRID, MINT21900206 details
RASK_HUMANEF1A1_HUMANBioGRID, MINT21900206 27684187 details
RASK_HUMANIGS21_HUMANBioGRID, MINT21900206 details
RASK_HUMANMYOME_HUMANBioGRID, MINT21900206 details
RASK_HUMANCDK8_HUMANBioGRID, MINT24412244 details
RASK_HUMANFANCC_HUMANBioGRID, MINT24412244 details
RASK_HUMANFRAT2_HUMANBioGRID, MINT24412244 details
RASK_HUMANHEMGN_HUMANBioGRID, MINT24412244 details
RASK_HUMANIBP3_HUMANBioGRID, MINT24412244 details
RASK_HUMANPP2AB_HUMANBioGRID, MINT24412244 details
RASK_HUMANSTX17_HUMANBioGRID, MINT24412244 details
RASK_HUMANZN189_HUMANBioGRID, MINT24412244 details
RASK_HUMANCYB_HUMANBioGRID, MINT25640309 details
RASK_HUMANMOC2A_HUMANBioGRID, MINT25640309 details
RASK_HUMANCOX3_HUMANBioGRID, MINT25640309 details
RASK_HUMANQCR1_HUMANBioGRID, MINT25640309 details
RASK_HUMANDHPR_HUMANBioGRID, MINT25640309 details
RASK_HUMANTNF13_HUMANBioGRID, MINT25640309 details
RASK_HUMANBCAS3_HUMANBioGRID, MINT25640309 details
RASK_HUMANDIRA3_HUMANBioGRID, MINT25640309 details
RASK_HUMANCCL5_HUMANBioGRID, MINT25640309 details
RASK_HUMANIL24_HUMANBioGRID, MINT25640309 details
RASK_HUMANOSGI1_HUMANBioGRID, MINT25640309 details
RASK_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
RASK_HUMANSPB5_HUMANBioGRID, MINT25640309 details
RASK_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
RASK_HUMANARAF_HUMANBioGRID, IntAct25416956 25852190 28205554 30194290 34079125 details
RASK_HUMANBRAF_HUMANBioGRID, IntAct27034005 27684187 28205554 28514442 30194290 31980649 34079125 details
RASK_HUMANPDE6D_HUMANDIP23698361 details
RASK_HUMANRASK_HUMANBioGRID, DIP26051715 27213482 27684187 30194290 30442766 30639242 details
RASK_HUMANA4_HUMANBioGRID, IntAct21832049 30194290 32814053 details
RASK_HUMANGDS1_HUMANBioGRID, HPRD11948427 20709748 details
RASK_HUMANSHOC2_HUMANBioGRID, HPRD10783161 34079125 9674433 details
RASK_HUMANPK3CA_HUMANBioGRID10783161 34079125 details
RASK_HUMANRASF5_HUMANBioGRID, HPRD11857081 details
RASK_HUMANEPB42_HUMANBioGRID, HPRD3276554 details
RASK_HUMANPK3CG_HUMANBioGRID, HPRD10542052 details
RASK_HUMANRGRF2_HUMANBioGRID11238945 details
RASK_HUMANDNJA3_HUMANBioGRID18624398 details
RASK_HUMANCALM1_HUMANBioGRID, HPRD11585916 12727204 27684187 details
RASK_HUMANCALM2_HUMANBioGRID, HPRD11585916 12727204 27684187 details
RASK_HUMANCALM3_HUMANBioGRID, HPRD11585916 12727204 27684187 details
RASK_HUMANMDFI_HUMANBioGRID25416956 details
RASK_HUMANPSA3_HUMANBioGRID25416956 details
RASK_HUMANRBPMS_HUMANBioGRID25416956 details
RASK_HUMANMOC2B_HUMANBioGRID25640309 details
RASK_HUMANPRAF3_HUMANBioGRID27229929 30194290 details
RASK_HUMANLYPD4_HUMANBioGRID27229929 details
RASK_HUMANNDUAD_HUMANBioGRID27229929 details
RASK_HUMANRHOA_HUMANBioGRID27229929 30194290 details
RASK_HUMANLZTR1_HUMANBioGRID30194290 30442762 30442766 30872527 31337872 34079125 details
RASK_HUMANRASH_HUMANBioGRID30194290 30442766 30655611 details
RASK_HUMANMTOR_HUMANBioGRID30639242 34079125 details
RASK_HUMANPI51A_HUMANBioGRID30194290 34079125 details
RASK_HUMANWDR76_HUMANBioGRID30655611 details
RASK_HUMANSOX4_HUMANBioGRID28205554 details
RASK_HUMANGRB7_HUMANIntAct29290818 details
RASK_HUMANSOS2_HUMANIntAct29290818 details
RASK_HUMANPHB_HUMANBioGRID16041367 details
RASK_HUMANMK01_HUMANBioGRID10958680 details
RASK_HUMANFBW1A_HUMANBioGRID24709419 details
RASK_HUMANBCL2_HUMANBioGRID, HPRD10490827 19433448 details
RASK_HUMANTRAF6_HUMANBioGRID24026882 details
RASK_HUMANNIBA2_HUMANBioGRID26721396 30442766 30639242 34079125 details
RASK_HUMANSPSB1_HUMANBioGRID29534718 details
RASK_HUMANRAGE_HUMANBioGRID25341034 details
RASK_HUMANRICTR_HUMANBioGRID30442766 30639242 34079125 details
RASK_HUMANEGFR_HUMANBioGRID12783862 30194290 30639242 34079125 details
RASK_HUMANSIN1_HUMANBioGRID30639242 34079125 details
RASK_HUMANCUL3_HUMANBioGRID31337872 details
RASK_HUMANPGTB1_HUMANHPRD15451670 details
RASK_HUMANFNTA_HUMANHPRD12374986 details
RASK_HUMANFNTB_HUMANHPRD12374986 details