Entity Details

Primary name LDLR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01130
EntryNameLDLR_HUMAN
FullNameLow-density lipoprotein receptor
TaxID9606
Evidenceevidence at protein level
Length860
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesLDLR

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001618 virus receptor activity
GO:0002020 protease binding
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005509 calcium ion binding
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 clathrin-coated pit
GO:0006629 lipid metabolic process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0007616 long-term memory
GO:0008203 cholesterol metabolic process
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010899 regulation of phosphatidylcholine catabolic process
GO:0015914 phospholipid transport
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030169 low-density lipoprotein particle binding
GO:0030229 very-low-density lipoprotein particle receptor activity
GO:0030299 intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032050 clathrin heavy chain binding
GO:0034362 low-density lipoprotein particle
GO:0034381 plasma lipoprotein particle clearance
GO:0034382 chylomicron remnant clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0036020 endolysosome membrane
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0051246 regulation of protein metabolic process
GO:0051248 negative regulation of protein metabolic process
GO:0061024 membrane organization
GO:0061771 response to caloric restriction
GO:0061889 negative regulation of astrocyte activation
GO:0070508 cholesterol import
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
GO:0097242 amyloid-beta clearance
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1903979 negative regulation of microglial cell activation
GO:1905167 positive regulation of lysosomal protein catabolic process
GO:1905907 negative regulation of amyloid fibril formation
GO:1990666 PCSK9-LDLR complex

Subcellular Location

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Subcellular Location
Cell membrane
Early endosome
Golgi apparatus
Late endosome
Lysosome
Membrane

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00707 Porfimer sodiumDrugbanksmall molecule
DB09270 UbidecarenoneDrugbanksmall molecule
DB11251 TocopherolSwissprotsmall molecule
DB14003 alpha-Tocopherol acetateSwissprotsmall molecule

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
LDLR_HUMANPDIA3_HUMANBioGRID, MINT17170699 details
LDLR_HUMANCBP_HUMANBioGRID, MINT18660751 details
LDLR_HUMANMAP4_HUMANBioGRID, IntAct21988832 details
LDLR_HUMANPCSK9_HUMANBioGRID, DIP, HPRD, MINT17435765 18250299 18753623 22081141 23085658 25613181 details
LDLR_HUMANARH_HUMANbhf-ucl, BioGRID, HPRD12221107 12746448 details
LDLR_HUMANAPOB_HUMANHPRD, MINT12031600 24447298 details
LDLR_HUMANAPOE_HUMANHPRD, MINT, UniProt12036962 20030366 24447298 details
LDLR_HUMANLDLR_HUMANHPRD, MINT10884290 26526611 details
LDLR_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
LDLR_HUMANIF3M_HUMANBioGRID, IntAct32296183 details
LDLR_HUMANAMRP_HUMANBioGRID, HPRD, IntAct, UniProt20030366 28514442 7822276 details
LDLR_HUMANAPOH_HUMANDIP20223219 details
LDLR_HUMANDAB1_HUMANBioGRID, HPRD10380922 10827173 9837937 details
LDLR_HUMANPLF4_HUMANBioGRID, HPRD11986215 details
LDLR_HUMANCD36_HUMANBioGRID9555943 details
LDLR_HUMANDAB2_HUMANBioGRID11247302 details
LDLR_HUMANSNX17_HUMANBioGRID, HPRD12169628 details
LDLR_HUMANMYLIP_HUMANBioGRID21685362 21734303 22109552 23382078 26666640 32727844 details
LDLR_HUMANVGFR1_HUMANMINT17962812 details
LDLR_HUMANAP1M2_HUMANBioGRID, HPRD11157985 details
LDLR_HUMANBIP_HUMANBioGRID, HPRD10906332 16257961 details
LDLR_HUMANENPL_HUMANBioGRID16257961 details
LDLR_HUMANPDIA4_HUMANBioGRID16257961 details
LDLR_HUMANCALX_HUMANBioGRID16257961 details
LDLR_HUMANUBP2_HUMANBioGRID26666640 details
LDLR_HUMANFGF11_HUMANBioGRID28027390 details