Entity Details

Primary name FINC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02751
EntryNameFINC_HUMAN
FullNameFibronectin
TaxID9606
Evidenceevidence at protein level
Length2477
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesFN1

GO terms

Show/Hide Table
GOName
GO:0001525 angiogenesis
GO:0001932 regulation of protein phosphorylation
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005201 extracellular matrix structural constituent
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0006953 acute-phase response
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008022 protein C-terminus binding
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009611 response to wounding
GO:0010628 positive regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016324 apical plasma membrane
GO:0016504 peptidase activator activity
GO:0018149 peptide cross-linking
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0030198 extracellular matrix organization
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0033622 integrin activation
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035987 endodermal cell differentiation
GO:0042802 identical protein binding
GO:0043394 proteoglycan binding
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045773 positive regulation of axon extension
GO:0048146 positive regulation of fibroblast proliferation
GO:0050900 leukocyte migration
GO:0051087 chaperone binding
GO:0051702 biological process involved in interaction with symbiont
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071635 negative regulation of transforming growth factor beta production
GO:0072378 blood coagulation, fibrin clot formation
GO:0072562 blood microparticle
GO:0097718 disordered domain specific binding
GO:1901166 neural crest cell migration involved in autonomic nervous system development
GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000083 Fibronectin, type IDomainDomain
IPR000562 Fibronectin type II domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036943 Fibronectin type II domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
184255 OMIMSpondylometaphyseal dysplasia, corner fracture type (SMDCF)An autosomal dominant form of spondylometaphyseal dysplasia, a group of short stature disorders distinguished by abnormalities in the vertebrae and the metaphyses of the tubular bones. SMDCF is characterized by flake-like, triangular, or curvilinear ossification centers at the edges of irregular metaphyses that simulate fractures. These corner fractures involve the distal tibia, the ulnar aspect of the distal radius, the proximal humerus, and the proximal femur. They represent irregular ossification at the growth plates and secondary ossification centers. The disease is caused by variants affecting the gene represented in this entry.
601894 OMIMGlomerulopathy with fibronectin deposits 2 (GFND2)Genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB06245 LanoteplaseDrugbankbiotech
DB08888 OcriplasminDrugbankbiotech
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

132 interactions

InteractorPartnerSourcesPublicationsLink
FINC_HUMANCCN2_HUMANMINT16457822 details
FINC_HUMANITA5_HUMANBioGRID, HPRD, IntAct, MINT11801679 1532572 16457822 1694173 19738201 20643357 24789099 25237190 26456826 7681433 9211865 details
FINC_HUMANUTER_HUMANHPRD, MINT10470078 18243143 details
FINC_HUMANCD79A_HUMANMINT18243143 details
FINC_HUMANGRB2_HUMANBioGRID, IntAct18624398 19738201 details
FINC_HUMANFYN_HUMANMINT17130124 details
FINC_HUMANITB3_HUMANBioGRID, DIP, HPRD, IntAct11478883 1694173 24658351 24789099 details
FINC_HUMANTSP1_HUMANHPRD, IntAct11773026 18042364 19542224 details
FINC_HUMANATX7_HUMANBioGRID, IntAct21078624 details
FINC_HUMANCDN2A_HUMANBioGRID, IntAct21988832 details
FINC_HUMANFBLN1_HUMANBioGRID, HPRD, IntAct1400330 21988832 details
FINC_HUMANHRG_HUMANBioGRID, IntAct21988832 details
FINC_HUMANRBL1_HUMANBioGRID, IntAct21988832 details
FINC_HUMANIMA1_HUMANBioGRID, IntAct19738201 21988832 details
FINC_HUMANSMAD4_HUMANBioGRID, HPRD, IntAct15231748 21988832 details
FINC_HUMANRARA_HUMANBioGRID, IntAct21988832 details
FINC_HUMANSTA5A_HUMANBioGRID, IntAct21988832 details
FINC_HUMANNR0B2_HUMANBioGRID, IntAct21988832 details
FINC_HUMANKS6A5_HUMANBioGRID, IntAct21988832 details
FINC_HUMANTAB1_HUMANBioGRID, IntAct21988832 details
FINC_HUMANDUS10_HUMANBioGRID, IntAct21988832 details
FINC_HUMANTAB2_HUMANBioGRID, IntAct21988832 details
FINC_HUMANPELI2_HUMANBioGRID, IntAct21988832 details
FINC_HUMANEP300_HUMANIntAct21988832 details
FINC_HUMANEGFR_HUMANBioGRID, IntAct20029029 details
FINC_HUMANITB1_HUMANBioGRID, IntAct, MINT19738201 21985969 24789099 25237190 26456826 7681433 details
FINC_HUMANSGCA_HUMANBioGRID, IntAct23414517 details
FINC_HUMANSHLB1_HUMANBioGRID, IntAct23414517 details
FINC_HUMANTITIN_HUMANBioGRID, IntAct23414517 details
FINC_HUMANZYX_HUMANBioGRID, IntAct, mbinfo11423549 19738201 details
FINC_HUMANPGBM_HUMANBioGRID, IntAct11493006 19738201 details
FINC_HUMANTGM2_HUMANBioGRID, DIP, HPRD, IntAct, matrixdb11278623 11686302 11829448 19738201 20080707 22442151 details
FINC_HUMANFINC_HUMANDIP, HPIDb, IntAct, matrixdb17914904 18042364 18160478 19826086 19931242 20541508 details
FINC_HUMANTNFL6_HUMANBioGRID, HPRD, IntAct11276204 25241761 details
FINC_HUMANGRAB_HUMANmatrixdb23228447 details
FINC_HUMANLYOX_HUMANmatrixdb21690299 details
FINC_HUMANAPOA_HUMANbhf-ucl2531657 9269765 details
FINC_HUMANFBN2_HUMANMINT25034023 details
FINC_HUMANFBN1_HUMANMINT25034023 details
FINC_HUMANFBN3_HUMANMINT25034023 details
FINC_HUMANAP2C_HUMANIntAct24835590 details
FINC_HUMANCO1A1_HUMANDIP, HPRD, matrixdb, MINT20541508 25290767 26848503 8468356 details
FINC_HUMANCO5A1_HUMANmatrixdb20979576 details
FINC_HUMANUBQL1_HUMANBioGRID, IntAct25416956 details
FINC_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
FINC_HUMANLOXL3_HUMANmatrixdb26954549 details
FINC_HUMANPGS2_HUMANHPRD, matrixdb1468447 1747115 details
FINC_HUMANTSG6_HUMANIntAct18042364 details
FINC_HUMANFA20C_HUMANIntAct26091039 details
FINC_HUMANPDGFA_HUMANDIP19966216 details
FINC_HUMANARMS2_HUMANIntAct19696174 details
FINC_HUMANLOXL2_HUMANmatrixdb31759052 details
FINC_HUMANC163A_HUMANMINT22309204 details
FINC_HUMANFCN2_HUMANIntAct27141819 details
FINC_HUMANFCN3_HUMANIntAct27141819 details
FINC_HUMANCCN3_HUMANBioGRID, HPRD12902636 details
FINC_HUMANCO7A1_HUMANBioGRID, HPRD7963647 9169408 details
FINC_HUMANBGH3_HUMANBioGRID, HPRD11867580 12034705 details
FINC_HUMANSDF1_HUMANBioGRID, HPRD11023498 details
FINC_HUMANPKD1_HUMANBioGRID, HPRD11752017 details
FINC_HUMANLACRT_HUMANBioGRID, HPRD11419941 details
FINC_HUMANIBP3_HUMANBioGRID, HPRD11344214 12127836 details
FINC_HUMANMIA_HUMANBioGRID, HPRD11157741 details
FINC_HUMANTENA_HUMANBioGRID, HPRD21349332 7499434 details
FINC_HUMANGELS_HUMANBioGRID, HPRD23750785 6092370 details
FINC_HUMANC1QA_HUMANBioGRID, HPRD6981115 details
FINC_HUMANITB6_HUMANBioGRID, HPRD1532572 details
FINC_HUMANCD44_HUMANBioGRID1730778 details
FINC_HUMANMYOC_HUMANBioGRID, HPRD11773026 details
FINC_HUMANCRP_HUMANBioGRID, HPRD6693419 details
FINC_HUMANF13A_HUMANBioGRID, HPRD8905624 details
FINC_HUMANMEP1A_HUMANBioGRID, HPRD8063866 details
FINC_HUMANMEP1B_HUMANBioGRID, HPRD8063866 details
FINC_HUMANREG3A_HUMANBioGRID, HPRD8997243 details
FINC_HUMANSDC2_HUMANBioGRID, HPRD10772816 details
FINC_HUMANTSHR_HUMANBioGRID, HPRD11981027 details
FINC_HUMANFBLN2_HUMANBioGRID, HPRD10848816 7500359 details
FINC_HUMANPLMN_HUMANBioGRID8360181 details
FINC_HUMANTPA_HUMANBioGRID8360181 details
FINC_HUMANTRIB3_HUMANBioGRID18276110 details
FINC_HUMANATX10_HUMANBioGRID16498633 details
FINC_HUMANHS90A_HUMANBioGRID19738201 31273033 details
FINC_HUMANARF_HUMANBioGRID21988832 details
FINC_HUMANITA2B_HUMANBioGRID11478883 details
FINC_HUMANKALM_HUMANBioGRID20874775 details
FINC_HUMANTIMD4_HUMANBioGRID30451988 details
FINC_HUMANVEGFA_HUMANBioGRID12114318 details
FINC_HUMANITA3_HUMANBioGRID7681433 details
FINC_HUMANLTBP1_HUMANBioGRID, HPRD25369932 8756760 details
FINC_HUMANIBP5_HUMANHPRD14645245 details
FINC_HUMANATS4_HUMANHPRD15161923 details
FINC_HUMANFSTL3_HUMANHPRD16336961 details
FINC_HUMANSKIL_HUMANHPRD15231748 details
FINC_HUMANPR40A_HUMANHPRD15231748 details
FINC_HUMANSMAD9_HUMANHPRD15231748 details
FINC_HUMANVHL_HUMANBioGRID, HPRD, MINT11024059 15060148 17700531 18323857 18523483 21942715 9651579 9751722 details
FINC_HUMANPAXI_HUMANBioGRID, IntAct, MINT19738201 21985969 details
FINC_HUMANITA4_HUMANBioGRID, HPRD, IntAct11010812 19738201 24789099 9117345 details
FINC_HUMANMYH9_HUMANBioGRID, IntAct19738201 23750785 details
FINC_HUMANHGF_HUMANBioGRID, HPRD, IntAct15717924 25241761 details
FINC_HUMANKLK3_HUMANBioGRID, HPRD, IntAct25241761 9016396 details
FINC_HUMANLG3BP_HUMANBioGRID, HPRD, IntAct28514442 9501082 details
FINC_HUMANMMP9_HUMANBioGRID, HPRD, IntAct11134254 28514442 details
FINC_HUMANHXA1_HUMANMINT21653829 details
FINC_HUMANAMBP_HUMANBioGRID, HPRD7519849 details
FINC_HUMANSAMP_HUMANBioGRID, HPRD12100475 details
FINC_HUMANITB7_HUMANBioGRID, HPRD1372909 details
FINC_HUMANITIH2_HUMANBioGRID23750785 details
FINC_HUMANITB5_HUMANBioGRID30451988 details
FINC_HUMANSPRC_HUMANHPRD2745554 details
FINC_HUMANGALT6_HUMANHPRD10464263 details
FINC_HUMANCATD_HUMANHPRD3988746 details
FINC_HUMANITA8_HUMANHPRD7559467 details
FINC_HUMANCO6A2_HUMANHPRD8168508 details
FINC_HUMANCOMP_HUMANHPRD12225811 details
FINC_HUMANTR11B_HUMANHPRD15799029 details
FINC_HUMANCO4A3_HUMANHPRD3997552 details
FINC_HUMANCO4A2_HUMANHPRD3997552 details
FINC_HUMANCO4A1_HUMANHPRD3997552 details
FINC_HUMANCO4A4_HUMANHPRD3997552 details
FINC_HUMANCO2A1_HUMANHPRD2229073 3997552 details
FINC_HUMANCO1A2_HUMANHPRD8468356 details
FINC_HUMANFST_HUMANHPRD16336961 details
FINC_HUMAN5NTD_HUMANHPRD10470109 9361795 details
FINC_HUMANMAG_HUMANHPRD11423128 details
FINC_HUMANCO4A5_HUMANHPRD3997552 details
FINC_HUMANCO4A6_HUMANHPRD3997552 details
FINC_HUMANPRELP_HUMANHPRD11847210 details
FINC_HUMANMATN2_HUMANHPRD12180907 details
FINC_HUMANTKN1_HUMANHPRD11342427 details
FINC_HUMANA2GL_HUMANHPRD11801638 details
FINC_HUMANTMPS6_HUMANHPRD12149247 details