Entity Details
| Primary name |
NU4LM_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | P03901 |
| EntryName | NU4LM_HUMAN |
| FullName | NADH-ubiquinone oxidoreductase chain 4L |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 98 |
| SequenceStatus | complete |
| DateCreated | 1986-07-21 |
| DateModified | 2021-06-02 |
GO terms
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| GO | Name |
| GO:0005743 | mitochondrial inner membrane |
| GO:0005747 | mitochondrial respiratory chain complex I |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| GO:0016021 | integral component of membrane |
Subcellular Location
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| Subcellular Location |
| Mitochondrion inner membrane |
Domains
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| Domain | Name | Category | Type |
| IPR001133 | NADH-ubiquinone oxidoreductase chain 4L/K | Family | Family |
| IPR039428 | NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like | Family | Family |
Diseases
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| Disease ID | Source | Name | Description |
| 535000 | OMIM | Leber hereditary optic neuropathy (LHON) | A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. The disease is caused by variants affecting the gene represented in this entry. |
Drugs
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| Drug | Name | Source | Type |
| DB00157 | NADH | Drugbank | small molecule |
Interactions
3 interactions