Entity Details

Primary name SODM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04179
EntryNameSODM_HUMAN
FullNameSuperoxide dismutase [Mn], mitochondrial
TaxID9606
Evidenceevidence at protein level
Length222
SequenceStatuscomplete
DateCreated1987-03-20
DateModified2021-06-02

Ontological Relatives

GenesSOD2

GO terms

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GOName
GO:0000303 response to superoxide
GO:0001315 age-dependent response to reactive oxygen species
GO:0001666 response to hypoxia
GO:0001836 release of cytochrome c from mitochondria
GO:0003069 acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
GO:0003677 DNA binding
GO:0004784 superoxide dismutase activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006801 superoxide metabolic process
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009409 response to cold
GO:0010042 response to manganese ion
GO:0010043 response to zinc ion
GO:0010269 response to selenium ion
GO:0010729 positive regulation of hydrogen peroxide biosynthetic process
GO:0014823 response to activity
GO:0019430 removal of superoxide radicals
GO:0019825 oxygen binding
GO:0019899 enzyme binding
GO:0030145 manganese ion binding
GO:0030335 positive regulation of cell migration
GO:0032364 oxygen homeostasis
GO:0032496 response to lipopolysaccharide
GO:0033591 response to L-ascorbic acid
GO:0034021 response to silicon dioxide
GO:0034599 cellular response to oxidative stress
GO:0035722 interleukin-12-mediated signaling pathway
GO:0035900 response to isolation stress
GO:0035902 response to immobilization stress
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042645 mitochondrial nucleoid
GO:0042802 identical protein binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0046686 response to cadmium ion
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051289 protein homotetramerization
GO:0051602 response to electrical stimulus
GO:0070062 extracellular exosome
GO:0071000 response to magnetism
GO:0071361 cellular response to ethanol
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902631 negative regulation of membrane hyperpolarization
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process
GO:1905932 positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR001189 Manganese/iron superoxide dismutaseFamilyFamily
IPR019831 Manganese/iron superoxide dismutase, N-terminalDomainDomain
IPR019832 Manganese/iron superoxide dismutase, C-terminalDomainDomain
IPR019833 Manganese/iron superoxide dismutase, binding siteSiteBinding site
IPR036314 Manganese/iron superoxide dismutase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036324 Manganese/iron superoxide dismutase, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB03297 Benzylsulfonic acidDrugbanksmall molecule
DB04436 3-Fluoro-L-tyrosineDrugbanksmall molecule
DB06796 MangafodipirSwissprotsmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB11590 ThimerosalDrugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
SODM_HUMANRS3A_HUMANBioGRID, HPRD, IntAct16169070 details
SODM_HUMANNOL12_HUMANBioGRID, HPRD, IntAct16169070 details
SODM_HUMANGET4_HUMANHPRD, IntAct16169070 details
SODM_HUMANK1549_HUMANHPRD, IntAct16169070 details
SODM_HUMANSODM_HUMANBioGRID, HPRD, IntAct, MINT10852710 1394426 14638684 19822147 21988832 2738919 details
SODM_HUMANCP4FC_HUMANBioGRID, IntAct21988832 details
SODM_HUMANSTK4_HUMANIntAct23386615 details
SODM_HUMANCEP70_HUMANBioGRID, IntAct32296183 details
SODM_HUMANNAL12_HUMANI2D32226298 details
SODM_HUMANUBP36_HUMANBioGRID21268071 details
SODM_HUMANA4_HUMANBioGRID21832049 details
SODM_HUMANHDHD2_HUMANHPRD16169070 details
SODM_HUMANRAB4A_HUMANHPRD, IntAct123234 16169070 details
SODM_HUMANARF6_HUMANIntAct17353931 details
SODM_HUMANPAK2_HUMANIntAct17353931 details
SODM_HUMANEIF1B_HUMANIntAct17353931 details
SODM_HUMANTNIK_HUMANIntAct17353931 details
SODM_HUMANCRCM_HUMANIntAct17353931 details
SODM_HUMANRIPK2_HUMANIntAct17353931 details
SODM_HUMANVHL_HUMANIntAct17353931 details
SODM_HUMANCYTN_HUMANIntAct17353931 details
SODM_HUMANMYH8_HUMANIntAct17353931 details
SODM_HUMANAMY1B_HUMANIntAct17353931 details
SODM_HUMANAMY1C_HUMANIntAct17353931 details
SODM_HUMANAMY1A_HUMANIntAct17353931 details
SODM_HUMANIKKE_HUMANIntAct17353931 details
SODM_HUMANHLAB_HUMANIntAct17353931 details
SODM_HUMAN3MG_HUMANIntAct17353931 details
SODM_HUMANCYTS_HUMANIntAct17353931 details
SODM_HUMANDC1L1_HUMANIntAct20195357 details
SODM_HUMANPIP30_HUMANIntAct20195357 details
SODM_HUMANPDIA1_HUMANIntAct20195357 details
SODM_HUMANTM131_HUMANIntAct20195357 details
SODM_HUMANRL21_HUMANIntAct20195357 details
SODM_HUMANGOGB1_HUMANIntAct20195357 details
SODM_HUMANENPL_HUMANIntAct20195357 details
SODM_HUMANSMCA2_HUMANIntAct20195357 details
SODM_HUMANPRDM2_HUMANIntAct20195357 details
SODM_HUMANSCRN1_HUMANIntAct20195357 details
SODM_HUMANTCAL9_HUMANIntAct20195357 details
SODM_HUMANSMCA5_HUMANIntAct20195357 details
SODM_HUMANRSCA1_HUMANBioGRID27555600 details