Entity Details

Primary name IL4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05112
EntryNameIL4_HUMAN
FullNameInterleukin-4
TaxID9606
Evidenceevidence at protein level
Length153
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesIL4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001774 microglial cell activation
GO:0002227 innate immune response in mucosa
GO:0002230 positive regulation of defense response to virus by host
GO:0002674 negative regulation of acute inflammatory response
GO:0002677 negative regulation of chronic inflammatory response
GO:0005125 cytokine activity
GO:0005136 interleukin-4 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006955 immune response
GO:0008083 growth factor activity
GO:0008203 cholesterol metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010633 negative regulation of epithelial cell migration
GO:0016239 positive regulation of macroautophagy
GO:0019221 cytokine-mediated signaling pathway
GO:0030183 B cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0031296 B cell costimulation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0042092 type 2 immune response
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042116 macrophage activation
GO:0042325 regulation of phosphorylation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042976 activation of Janus kinase activity
GO:0043011 myeloid dendritic cell differentiation
GO:0043031 negative regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043306 positive regulation of mast cell degranulation
GO:0045064 T-helper 2 cell differentiation
GO:0045191 regulation of isotype switching
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045582 positive regulation of T cell differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048295 positive regulation of isotype switching to IgE isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050728 negative regulation of inflammatory response
GO:0050776 regulation of immune response
GO:0071677 positive regulation of mononuclear cell migration
GO:0097028 dendritic cell differentiation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0150076 neuroinflammatory response
GO:0150079 negative regulation of neuroinflammatory response
GO:1900223 positive regulation of amyloid-beta clearance
GO:1901741 positive regulation of myoblast fusion
GO:1901857 positive regulation of cellular respiration
GO:1903660 negative regulation of complement-dependent cytotoxicity
GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus
GO:2000320 negative regulation of T-helper 17 cell differentiation
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000424 positive regulation of eosinophil chemotaxis
GO:2000553 positive regulation of T-helper 2 cell cytokine production
GO:2001171 positive regulation of ATP biosynthetic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001325 Interleukin-4/interleukin-13FamilyFamily
IPR002354 Interleukin-4FamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily
IPR018096 Interleukin-4/interleukin-13, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB06560 PascolizumabDrugbankbiotech