Entity Details

Primary name IC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05155
EntryNameIC1_HUMAN
FullNamePlasma protease C1 inhibitor
TaxID9606
Evidenceevidence at protein level
Length500
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesSERPING1

GO terms

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GOName
GO:0001869 negative regulation of complement activation, lectin pathway
GO:0002576 platelet degranulation
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0006958 complement activation, classical pathway
GO:0007597 blood coagulation, intrinsic pathway
GO:0008015 blood circulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030449 regulation of complement activation
GO:0031093 platelet alpha granule lumen
GO:0042730 fibrinolysis
GO:0045087 innate immune response
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:2000267 negative regulation of blood coagulation, intrinsic pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000215 Serpin familyFamilyFamily
IPR015553 Plasma protease C1 inhibitorFamilyFamily
IPR023795 Serpin, conserved siteSiteConserved site
IPR023796 Serpin domainDomainDomain
IPR036186 Serpin superfamilyFamilyHomologous superfamily
IPR042178 Serpin superfamily, domain 1FamilyHomologous superfamily
IPR042185 Serpin superfamily, domain 2FamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05961 PPL-100Drugbanksmall molecule
DB09130 CopperDrugbanksmall molecule