Entity Details

Primary name IF4E_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06730
EntryNameIF4E_HUMAN
FullNameEukaryotic translation initiation factor 4E
TaxID9606
Evidenceevidence at protein level
Length217
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesEIF4E

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000339 RNA cap binding
GO:0000340 RNA 7-methylguanosine cap binding
GO:0000932 P-body
GO:0001662 behavioral fear response
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005845 mRNA cap binding complex
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0010494 cytoplasmic stress granule
GO:0016032 viral process
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0016442 RISC complex
GO:0017148 negative regulation of translation
GO:0019827 stem cell population maintenance
GO:0019899 enzyme binding
GO:0030324 lung development
GO:0031370 eukaryotic initiation factor 4G binding
GO:0033391 chromatoid body
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0045665 negative regulation of neuron differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0071549 cellular response to dexamethasone stimulus
GO:0098978 glutamatergic synapse
GO:0099524 postsynaptic cytosol
GO:0099578 regulation of translation at postsynapse, modulating synaptic transmission

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001040 Translation Initiation factor eIF- 4eFamilyFamily
IPR019770 Eukaryotic translation initiation factor 4E (eIF-4E), conserved siteSiteConserved site
IPR023398 Translation Initiation factor eIF- 4e-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01649 7-methyl-GpppADrugbanksmall molecule
DB01960 7-methyl-7,8-dihydroguanosine-5'-diphosphateDrugbanksmall molecule
DB02716 7-methyl-guanosine-5'-triphosphateDrugbanksmall molecule
DB05165 LY2275796Drugbanksmall molecule
DB08217 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioateDrugbanksmall molecule

Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
IF4E_HUMAN4EBP1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10364159 10405182 10698949 10753870 10772338 11553333 11605658 12071973 12588975 12747804 12867426 15094042 15153109 15767663 16189514 16242075 16271312 16504179 16648488 16798736 16824195 17254965 17353931 18955708 18957614 19834456 20224576 20880835 21191102 21798997 22509910 22586265 22678294 24211447 24722188 24931163 24981860 25416956 25940091 26186194 26344197 28514442 32296183 7651417 7935836 8816458 details
IF4E_HUMAN4EBP2_HUMANBioGRID, DIP, HPRD, IntAct, MINT15153109 16271312 20347422 24207126 24722188 24981860 25416956 26186194 26344197 28514442 31515488 32296183 7651417 7935836 8939971 details
IF4E_HUMAN4EBP3_HUMANBioGRID, HPRD, IntAct, MINT12482586 15153109 16271312 24722188 25416956 32296183 9593750 details
IF4E_HUMAN4ET_HUMANBioGRID, HPRD, IntAct, MINT10856257 16467844 19060904 24722188 24981860 25416956 25923732 26186194 28514442 29395067 details
IF4E_HUMANIF4G1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10600798 10753870 12071973 15153109 15361857 16281055 16541103 16648488 16720573 18955708 20212144 21191102 22509910 22586265 23665581 24981860 25923732 25940091 26186194 26344197 27864334 28514442 29987188 30573685 7651417 9372926 9418880 details
IF4E_HUMANGEMI5_HUMANBioGRID, IntAct16739988 details
IF4E_HUMANCYFP1_HUMANIntAct18805096 details
IF4E_HUMANPML_HUMANBioGRID, HPRD, MINT11500381 11575918 12167712 12438698 19262567 details
IF4E_HUMANCD83_HUMANBioGRID, IntAct21988832 details
IF4E_HUMANPRDM4_HUMANBioGRID, IntAct21988832 details
IF4E_HUMANTRI27_HUMANBioGRID, IntAct24722188 25416956 31515488 details
IF4E_HUMANT23O_HUMANBioGRID, IntAct24722188 25416956 details
IF4E_HUMANUBX11_HUMANBioGRID, IntAct24722188 25416956 details
IF4E_HUMANKANK2_HUMANBioGRID, IntAct24722188 25416956 32296183 details
IF4E_HUMANIF4G3_HUMANBioGRID, DIP, HPRD, IntAct, MINT20212144 21191102 24981860 26186194 26344197 28514442 9418880 details
IF4E_HUMANA4_HUMANBioGRID21832049 details
IF4E_HUMANBIRC2_HUMANBioGRID28852129 details
IF4E_HUMANPTEN_HUMANBioGRID31685992 details
IF4E_HUMANMKNK1_HUMANBioGRID, HPRD, MINT10022874 9155017 9878069 details
IF4E_HUMANEMX2_HUMANHPRD, IntAct15247416 details
IF4E_HUMANIF4A2_HUMANBioGRID, IntAct, MINT17353931 24981860 29395067 details
IF4E_HUMANPAK2_HUMANIntAct17353931 details
IF4E_HUMANSMYD2_HUMANIntAct17353931 details
IF4E_HUMANIF4A1_HUMANBioGRID, IntAct, MINT16648488 17353931 22586265 24981860 28514442 29395067 details
IF4E_HUMANTRAF6_HUMANIntAct17353931 details
IF4E_HUMANEIF3B_HUMANBioGRID, IntAct, MINT16541103 18423201 24981860 30573685 details
IF4E_HUMANG3BP1_HUMANBioGRID, MINT18005740 29395067 details
IF4E_HUMANDDX3X_HUMANMINT, UniProt18596238 19262567 21883093 22872150 details
IF4E_HUMANLPPRC_HUMANMINT19262567 details
IF4E_HUMANSUMO1_HUMANMINT20224576 details
IF4E_HUMANPP2AA_HUMANMINT20927323 details
IF4E_HUMANPABP1_HUMANBioGRID, DIP23665581 26344197 29395067 details
IF4E_HUMANEIF3F_HUMANBioGRID, MINT19615732 24981860 30573685 details
IF4E_HUMANEIF3A_HUMANBioGRID, MINT24981860 30573685 details
IF4E_HUMANCHIP_HUMANBioGRID16720573 28852129 details
IF4E_HUMANDCC_HUMANBioGRID20434207 details
IF4E_HUMANHSPB2_HUMANBioGRID20101233 details
IF4E_HUMANRPTOR_HUMANBioGRID16798736 details
IF4E_HUMANITA4_HUMANBioGRID22623428 details
IF4E_HUMANTRI22_HUMANBioGRID22509910 details
IF4E_HUMANOTU6B_HUMANBioGRID27864334 details
IF4E_HUMANSRSF3_HUMANBioGRID27381497 details
IF4E_HUMANMTA70_HUMANBioGRID30232453 details
IF4E_HUMANFMR1_HUMANBioGRID30361391 details
IF4E_HUMANCTNB1_HUMANBioGRID30361391 details
IF4E_HUMANPATL1_HUMANBioGRID29395067 details
IF4E_HUMANYTHD2_HUMANBioGRID29395067 details
IF4E_HUMANTTP_HUMANBioGRID29395067 details
IF4E_HUMANCELF1_HUMANBioGRID29395067 details
IF4E_HUMANIF4E_HUMANHPRD12482586 details
IF4E_HUMANKPCA_HUMANHPRD8662663 details
IF4E_HUMANKPCB_HUMANHPRD8662663 details
IF4E_HUMANKPCG_HUMANHPRD8662663 details
IF4E_HUMANIF4B_HUMANHPRD2016328 details
IF4E_HUMANMKNK2_HUMANHPRD12897141 9155017 details
IF4E_HUMANIF4G2_HUMANHPRD10394359 details
IF4E_HUMANMAPK5_HUMANHPRD9628874 details