Entity Details

Primary name SAP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07602
EntryNameSAP_HUMAN
FullNameProsaposin
TaxID9606
Evidenceevidence at protein level
Length524
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesPSAP

GO terms

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GOName
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0006687 glycosphingolipid metabolic process
GO:0007041 lysosomal transport
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0008047 enzyme activator activity
GO:0010506 regulation of autophagy
GO:0019216 regulation of lipid metabolic process
GO:0035577 azurophil granule membrane
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0060736 prostate gland growth
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:1903771 positive regulation of beta-galactosidase activity
GO:1905572 ganglioside GM1 transport to membrane
GO:1905573 ganglioside GM1 binding
GO:1905574 ganglioside GM2 binding
GO:1905575 ganglioside GM3 binding
GO:1905576 ganglioside GT1b binding
GO:1905577 ganglioside GP1c binding

Subcellular Location

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Subcellular Location
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR003119 Saposin A-type domainDomainDomain
IPR007856 Saposin-like type B, region 1DomainDomain
IPR008138 Saposin B type, region 2DomainDomain
IPR008139 Saposin B type domainDomainDomain
IPR008373 SaposinFamilyFamily
IPR011001 Saposin-likeFamilyHomologous superfamily
IPR021165 Saposin, chordataFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01966 Di-Stearoyl-3-Sn-PhosphatidylethanolamineDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
SAP_HUMANSMAD2_HUMANBioGRID, HPRD, MINT15231748 details
SAP_HUMANSMAD9_HUMANBioGRID, HPRD, MINT15231748 details
SAP_HUMANCSN6_HUMANBioGRID, HPRD, IntAct16169070 details
SAP_HUMANCELR1_HUMANBioGRID, HPRD, IntAct16169070 details
SAP_HUMANPRAG1_HUMANBioGRID, IntAct16169070 details
SAP_HUMANMAFF_HUMANBioGRID, HPRD, IntAct16169070 details
SAP_HUMANZBED1_HUMANBioGRID, HPRD, IntAct16713569 32296183 details
SAP_HUMANUBE3A_HUMANBioGRID, MINT21900206 details
SAP_HUMANSGCG_HUMANBioGRID, IntAct23414517 details
SAP_HUMANERBB2_HUMANBioGRID, MINT25640309 details
SAP_HUMANTRY3_HUMANIntAct24872419 details
SAP_HUMANKLK7_HUMANIntAct24872419 details
SAP_HUMANPEX5_HUMANBioGRID, IntAct32296183 details
SAP_HUMANAPBP2_HUMANBioGRID, IntAct32296183 details
SAP_HUMANHSPB2_HUMANbhf-ucl26465331 details
SAP_HUMANSAP_HUMANBioGRID, DIP, HPRD12510003 12518053 18462685 details
SAP_HUMANNLGN3_HUMANBioGRID, IntAct25464930 details
SAP_HUMANGRN_HUMANUniProt26370502 details
SAP_HUMANKC1D_HUMANIntAct32814053 details
SAP_HUMANLYN_HUMANIntAct32814053 details
SAP_HUMANA4_HUMANIntAct32814053 details
SAP_HUMANUBP4_HUMANBioGRID23022198 details
SAP_HUMANBRCA1_HUMANBioGRID, HPRD11313879 22990118 details
SAP_HUMANCPEB2_HUMANBioGRID22157746 details
SAP_HUMANBACE1_HUMANHPRD15606899 details
SAP_HUMANCASPE_HUMANIntAct24872419 details
SAP_HUMANTERA_HUMANDIP19570996 details
SAP_HUMANDISC1_HUMANIntAct31413325 details
SAP_HUMANCATD_HUMANBioGRID, HPRD12083803 details
SAP_HUMANGLCM_HUMANHPRD7613473 details
SAP_HUMANCD1B_HUMANHPRD14716313 details