Entity Details

Primary name ELNE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08246
EntryNameELNE_HUMAN
FullNameNeutrophil elastase
TaxID9606
Evidenceevidence at protein level
Length267
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesELANE

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001878 response to yeast
GO:0002020 protease binding
GO:0002438 acute inflammatory response to antigenic stimulus
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002812 biosynthetic process of antibacterial peptides active against Gram-negative bacteria
GO:0003714 transcription corepressor activity
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006508 proteolysis
GO:0006874 cellular calcium ion homeostasis
GO:0006909 phagocytosis
GO:0008201 heparin binding
GO:0008233 peptidase activity
GO:0009411 response to UV
GO:0009986 cell surface
GO:0017053 transcription repressor complex
GO:0019730 antimicrobial humoral response
GO:0019955 cytokine binding
GO:0022617 extracellular matrix disassembly
GO:0030141 secretory granule
GO:0030163 protein catabolic process
GO:0032496 response to lipopolysaccharide
GO:0032682 negative regulation of chemokine production
GO:0032717 negative regulation of interleukin-8 production
GO:0032757 positive regulation of interleukin-8 production
GO:0035578 azurophil granule lumen
GO:0035580 specific granule lumen
GO:0042742 defense response to bacterium
GO:0043312 neutrophil degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0045335 phagocytic vesicle
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050778 positive regulation of immune response
GO:0050922 negative regulation of chemotaxis
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070945 neutrophil-mediated killing of gram-negative bacterium
GO:0070947 neutrophil-mediated killing of fungus
GO:1903238 positive regulation of leukocyte tethering or rolling

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00019 PegfilgrastimDrugbankbiotech
DB00058 Alpha-1-proteinase inhibitorDrugbankbiotech
DB00099 FilgrastimDrugbankbiotech
DB02341 Mdl 101,146Drugbanksmall molecule
DB03925 FreselestatDrugbanksmall molecule
DB05161 ElafinDrugbanksmall molecule

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
ELNE_HUMANA1AT_HUMANBioGRID, HPRD, IntAct10867014 16321984 details
ELNE_HUMANSLPI_HUMANHPRD, UniProt10702419 18421166 details
ELNE_HUMANPROP_HUMANIntAct24355864 details
ELNE_HUMANNT2NC_HUMANBioGRID, HPRD14673143 details
ELNE_HUMANNT2NA_HUMANBioGRID, HPRD14673143 details
ELNE_HUMANAACT_HUMANBioGRID, HPRD8011628 8718849 details
ELNE_HUMANA2AP_HUMANBioGRID, HPRD2437112 6980881 details
ELNE_HUMANIC1_HUMANBioGRID, HPRD6980881 details
ELNE_HUMANTSP1_HUMANBioGRID, HPRD8463250 details
ELNE_HUMANILEU_HUMANBioGRID, HPRD10924364 details
ELNE_HUMANKNG1_HUMANBioGRID, HPRD12887060 details
ELNE_HUMANGRAB_HUMANMINT9404514 details
ELNE_HUMANITAM_HUMANHPRD15718918 details
ELNE_HUMANCSF3_HUMANHPRD14587040 details
ELNE_HUMANCSF3R_HUMANHPRD14587040 details
ELNE_HUMANCXCR4_HUMANHPRD12531874 details
ELNE_HUMANVCAM1_HUMANHPRD11520773 details
ELNE_HUMANSDF1_HUMANHPRD12068293 details
ELNE_HUMANTGFA_HUMANHPRD15245434 details
ELNE_HUMANPAR2_HUMANHPRD10978167 details
ELNE_HUMANPAR1_HUMANHPRD10978167 details
ELNE_HUMANELNE_HUMANHPRD12190311 details
ELNE_HUMANELN_HUMANHPRD10471600 details
ELNE_HUMANGRN_HUMANHPRD12526812 details
ELNE_HUMANHEP2_HUMANHPRD2318847 details
ELNE_HUMANTFPI1_HUMANHPRD10859319 12117418 1558967 details
ELNE_HUMANPAI1_HUMANHPRD7521069 details
ELNE_HUMANSDC1_HUMANHPRD9565572 details
ELNE_HUMANFA5_HUMANHPRD9242537 details
ELNE_HUMANCAMP_HUMANHPRD11389039 details
ELNE_HUMANSPB13_HUMANHPRD10512713 details
ELNE_HUMANSYYC_HUMANHPRD10102815 details
ELNE_HUMANLRP1_HUMANHPRD15131125 details