Entity Details

Primary name GNAI3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08754
EntryNameGNAI3_HUMAN
FullNameGuanine nucleotide-binding protein G(i) subunit alpha-3
TaxID9606
Evidenceevidence at protein level
Length354
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesGNAI3

GO terms

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GOName
GO:0001664 G protein-coupled receptor binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0006457 protein folding
GO:0006906 vesicle fusion
GO:0007049 cell cycle
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007212 dopamine receptor signaling pathway
GO:0007420 brain development
GO:0016020 membrane
GO:0016239 positive regulation of macroautophagy
GO:0019003 GDP binding
GO:0019904 protein domain specific binding
GO:0030168 platelet activation
GO:0030496 midbody
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031821 G protein-coupled serotonin receptor binding
GO:0032794 GTPase activating protein binding
GO:0032930 positive regulation of superoxide anion generation
GO:0033864 positive regulation of NAD(P)H oxidase activity
GO:0042588 zymogen granule
GO:0045121 membrane raft
GO:0046039 GTP metabolic process
GO:0046872 metal ion binding
GO:0051301 cell division
GO:0070062 extracellular exosome
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunitFamilyFamily
IPR001408 G-protein alpha subunit, group IFamilyFamily
IPR011025 G protein alpha subunit, helical insertionFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
602483 OMIMAuriculocondylar syndrome 1 (ARCND1)An autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
GNAI3_HUMANMTR1A_HUMANBioGRID, HPRD, IntAct10598579 17215244 26514267 details
GNAI3_HUMANMTR1B_HUMANBioGRID, HPRD, IntAct17215244 26514267 details
GNAI3_HUMANAT12A_HUMANBioGRID, IntAct21988832 details
GNAI3_HUMANSOX30_HUMANBioGRID, IntAct21988832 details
GNAI3_HUMANRAGP1_HUMANBioGRID, IntAct21988832 details
GNAI3_HUMANNUCB1_HUMANBioGRID, HPRD, IntAct11752444 21988832 9647645 details
GNAI3_HUMANNUCB2_HUMANBioGRID, IntAct21988832 details
GNAI3_HUMANRGS14_HUMANBioGRID, HPRD, IntAct11387333 21988832 26186194 28514442 32296183 details
GNAI3_HUMANRGS17_HUMANBioGRID, IntAct25416956 details
GNAI3_HUMANGPSM3_HUMANBioGRID, IntAct21516116 25416956 32296183 details
GNAI3_HUMANGPSM2_HUMANBioGRID, HPRD, IntAct12925752 32296183 details
GNAI3_HUMANPCP2_HUMANBioGRID, IntAct26186194 28514442 32296183 details
GNAI3_HUMANPHF24_HUMANBioGRID, IntAct32296183 details
GNAI3_HUMANRGS12_HUMANBioGRID, HPRD, IntAct11387333 26186194 28514442 details
GNAI3_HUMANRIC8A_HUMANBioGRID, HPRD, IntAct12509430 26186194 28514442 details
GNAI3_HUMANGBB4_HUMANBioGRID, IntAct16371464 26186194 28514442 details
GNAI3_HUMANGPSM1_HUMANBioGRID, IntAct12719437 21209316 26186194 28514442 details
GNAI3_HUMANGBB2_HUMANBioGRID, IntAct16371464 26186194 28514442 details
GNAI3_HUMANGBB1_HUMANBioGRID, IntAct16371464 22186894 22939629 26186194 28514442 details
GNAI3_HUMANRGS19_HUMANBioGRID, HPRD10364213 16293724 8524874 8986788 details
GNAI3_HUMANRGS18_HUMANBioGRID, HPRD11563974 11955952 details
GNAI3_HUMANRGS10_HUMANBioGRID, HPRD11443111 8774883 details
GNAI3_HUMANRGS2_HUMANBioGRID9079700 details
GNAI3_HUMANRGS5_HUMANBioGRID, HPRD11253162 9079700 details
GNAI3_HUMANRGS16_HUMANBioGRID, HPRD10072511 9079700 details
GNAI3_HUMANS1PR1_HUMANBioGRID, HPRD8626678 details
GNAI3_HUMANKAP3_HUMANBioGRID22186894 details
GNAI3_HUMANDAPLE_HUMANBioGRID25416956 32296183 details
GNAI3_HUMANGRDN_HUMANBioGRID21209316 25187647 26186194 details
GNAI3_HUMANRASA3_HUMANBioGRID18952607 details
GNAI3_HUMANEGFR_HUMANBioGRID19401591 25187647 details
GNAI3_HUMANRGS20_HUMANHPRD12379657 15488169 details
GNAI3_HUMANM3K3_HUMANIntAct14743216 details
GNAI3_HUMANRIPK3_HUMANIntAct14743216 details
GNAI3_HUMANGBG3_HUMANIntAct17353931 details
GNAI3_HUMANTRAF6_HUMANIntAct17353931 details
GNAI3_HUMANCNR1_HUMANBioGRID, HPRD11168387 details
GNAI3_HUMANC5AR1_HUMANBioGRID7962171 details
GNAI3_HUMANRGS3_HUMANBioGRID, HPRD9858594 details
GNAI3_HUMANRGS7_HUMANBioGRID, HPRD10092682 details
GNAI3_HUMANNCF2_HUMANBioGRID16782902 details
GNAI3_HUMANGBB3_HUMANBioGRID22940628 details
GNAI3_HUMANESR1_HUMANBioGRID22230296 details
GNAI3_HUMANGAB1_HUMANBioGRID19401591 details
GNAI3_HUMANCD59_HUMANHPRD8650218 details
GNAI3_HUMANCD48_HUMANHPRD8650218 details
GNAI3_HUMANGNAI3_HUMANHPRD12925752 details
GNAI3_HUMANCCR5_HUMANHPRD15251452 details
GNAI3_HUMANAGTR2_HUMANHPRD11055978 8663053 details
GNAI3_HUMANCXCR2_HUMANHPRD8316840 details
GNAI3_HUMANTSHR_HUMANHPRD8552586 details
GNAI3_HUMANPTPRU_HUMANHPRD16298104 details
GNAI3_HUMANDRD2_HUMANHPRD10978845 details
GNAI3_HUMANLPAR1_HUMANHPRD9600933 details
GNAI3_HUMANNGB_HUMANHPRD12860983 details
GNAI3_HUMAN5HT1A_HUMANHPRD8218170 details