Entity Details

Primary name CLUS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10909
EntryNameCLUS_HUMAN
FullNameClusterin
TaxID9606
Evidenceevidence at protein level
Length449
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCLU

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0001540 amyloid-beta binding
GO:0001774 microglial cell activation
GO:0001836 release of cytochrome c from mitochondria
GO:0002434 immune complex clearance
GO:0002576 platelet degranulation
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006629 lipid metabolic process
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0009615 response to virus
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0017038 protein import
GO:0019730 antimicrobial humoral response
GO:0030449 regulation of complement activation
GO:0031093 platelet alpha granule lumen
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031625 ubiquitin protein ligase binding
GO:0032286 central nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0034366 spherical high-density lipoprotein particle
GO:0042127 regulation of cell population proliferation
GO:0042583 chromaffin granule
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043691 reverse cholesterol transport
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045202 synapse
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046982 protein heterodimerization activity
GO:0048156 tau protein binding
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048471 perinuclear region of cytoplasm
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050821 protein stabilization
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051131 chaperone-mediated protein complex assembly
GO:0051787 misfolded protein binding
GO:0051788 response to misfolded protein
GO:0060548 negative regulation of cell death
GO:0061077 chaperone-mediated protein folding
GO:0061518 microglial cell proliferation
GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy
GO:0061741 obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097418 neurofibrillary tangle
GO:0097440 apical dendrite
GO:0099020 perinuclear endoplasmic reticulum lumen
GO:1900221 regulation of amyloid-beta clearance
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1902004 positive regulation of amyloid-beta formation
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430 negative regulation of amyloid-beta formation
GO:1902847 regulation of neuronal signal transduction
GO:1902949 positive regulation of tau-protein kinase activity
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1905892 negative regulation of cellular response to thapsigargin
GO:1905895 negative regulation of cellular response to tunicamycin
GO:1905907 negative regulation of amyloid fibril formation
GO:1905908 positive regulation of amyloid fibril formation
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum
Microsome
Mitochondrion
Mitochondrion membrane
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000753 Clusterin-likeFamilyFamily
IPR016014 Clusterin, N-terminalDomainDomain
IPR016015 Clusterin, C-terminalDomainDomain
IPR016016 ClusterinFamilyFamily
IPR033986 Clusterin, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

146 interactions

InteractorPartnerSourcesPublicationsLink
CLUS_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
CLUS_HUMANTNIK_HUMANBioGRID, IntAct17043677 31413325 details
CLUS_HUMANPDIA3_HUMANBioGRID, IntAct, MINT17170699 26496610 details
CLUS_HUMANGRB2_HUMANBioGRID, IntAct18624398 details
CLUS_HUMANFOS_HUMANBioGRID, IntAct20195357 details
CLUS_HUMANMDM2_HUMANBioGRID, IntAct20195357 details
CLUS_HUMANRPAC1_HUMANBioGRID, IntAct21988832 details
CLUS_HUMANCP2E1_HUMANBioGRID, IntAct21988832 details
CLUS_HUMANCTIP_HUMANBioGRID, IntAct21988832 details
CLUS_HUMANKLF11_HUMANBioGRID, IntAct21988832 details
CLUS_HUMANKEAP1_HUMANBioGRID, IntAct21988832 details
CLUS_HUMANT22D4_HUMANBioGRID, IntAct21988832 details
CLUS_HUMANMK09_HUMANBioGRID, IntAct21988832 details
CLUS_HUMANRL23_HUMANBioGRID, IntAct21988832 details
CLUS_HUMANBAG6_HUMANBioGRID, IntAct21988832 details
CLUS_HUMANPACA_HUMANMINT25451228 details
CLUS_HUMANSAV1_HUMANIntAct22570112 details
CLUS_HUMANMSRB1_HUMANBioGRID, UniProt23805218 details
CLUS_HUMANRTN1_HUMANIntAct25543119 details
CLUS_HUMANCLUS_HUMANBioGRID, IntAct12551933 17872975 31413325 details
CLUS_HUMANHS90A_HUMANBioGRID, IntAct31273033 31413325 details
CLUS_HUMANTWST1_HUMANIntAct19534813 details
CLUS_HUMANA4_HUMANBioGRID, HPRD, IntAct22528093 23805218 26884339 32814053 7802646 8328966 8752142 9228033 details
CLUS_HUMANTGFR2_HUMANBioGRID, HPRD8555189 details
CLUS_HUMANXRCC6_HUMANBioGRID, HPRD10219089 12551933 19118032 19177010 21042904 details
CLUS_HUMANCO8B_HUMANBioGRID, HPRD8345200 details
CLUS_HUMANCO7_HUMANBioGRID, HPRD8345200 details
CLUS_HUMANCO9_HUMANBioGRID, HPRD8345200 details
CLUS_HUMANLRP2_HUMANBioGRID, HPRD17260971 7768901 9228033 details
CLUS_HUMANTGFR1_HUMANBioGRID, HPRD8555189 details
CLUS_HUMANSYVN1_HUMANBioGRID17451556 details
CLUS_HUMANCOMD1_HUMANBioGRID20068069 22130675 details
CLUS_HUMANVHL_HUMANBioGRID22532874 details
CLUS_HUMANTTHY_HUMANBioGRID19664600 details
CLUS_HUMANCD209_HUMANBioGRID22013110 details
CLUS_HUMANACTN1_HUMANBioGRID17974975 details
CLUS_HUMANZWINT_HUMANBioGRID17974975 details
CLUS_HUMANKTNA1_HUMANBioGRID17974975 details
CLUS_HUMANSKAP_HUMANBioGRID17974975 details
CLUS_HUMANCBY1_HUMANBioGRID20096688 details
CLUS_HUMANELN_HUMANBioGRID17872975 details
CLUS_HUMANLYSC_HUMANBioGRID17407782 details
CLUS_HUMANCLUA1_HUMANBioGRID, HPRD15480429 details
CLUS_HUMANIL24_HUMANBioGRID21732348 details
CLUS_HUMANCH60_HUMANBioGRID22012253 details
CLUS_HUMANAPRIO_HUMANBioGRID18786636 details
CLUS_HUMANPRIO_HUMANBioGRID, HPRD15146195 18786636 details
CLUS_HUMANPAXI1_HUMANBioGRID21163940 details
CLUS_HUMANDNLI4_HUMANBioGRID22990118 details
CLUS_HUMANMDC1_HUMANBioGRID22990118 details
CLUS_HUMANUBC_HUMANBioGRID20068069 details
CLUS_HUMANEPPI_HUMANBioGRID17567961 details
CLUS_HUMANPACR_HUMANBioGRID25451228 details
CLUS_HUMANSRPK2_HUMANBioGRID26167880 details
CLUS_HUMANEIF3F_HUMANBioGRID26988917 details
CLUS_HUMANPLXA4_HUMANBioGRID27378688 details
CLUS_HUMANTREM2_HUMANBioGRID27477018 details
CLUS_HUMANLRP1_HUMANBioGRID31273033 details
CLUS_HUMANNR4A1_HUMANIntAct20195357 details
CLUS_HUMANGCR_HUMANIntAct20195357 details
CLUS_HUMANPPARG_HUMANIntAct20195357 details
CLUS_HUMANZNF24_HUMANIntAct20195357 details
CLUS_HUMANB2CL1_HUMANBioGRID, IntAct21527247 21567405 details
CLUS_HUMANENPL_HUMANBioGRID, IntAct22689054 26496610 details
CLUS_HUMANBIG2_HUMANIntAct31413325 details
CLUS_HUMANTEBP_HUMANIntAct31413325 details
CLUS_HUMANMO4L1_HUMANIntAct31413325 details
CLUS_HUMANFMNL2_HUMANIntAct31413325 details
CLUS_HUMANFMR1_HUMANIntAct31413325 details
CLUS_HUMANADHX_HUMANIntAct31413325 details
CLUS_HUMANSPRE1_HUMANIntAct31413325 details
CLUS_HUMANSYDC_HUMANIntAct31413325 details
CLUS_HUMANODO2_HUMANIntAct31413325 details
CLUS_HUMANSPRE2_HUMANIntAct31413325 details
CLUS_HUMANMYT1L_HUMANIntAct31413325 details
CLUS_HUMANMYCB2_HUMANIntAct31413325 details
CLUS_HUMANPEG10_HUMANIntAct31413325 details
CLUS_HUMANFRIH_HUMANIntAct31413325 details
CLUS_HUMANBICRL_HUMANIntAct31413325 details
CLUS_HUMANRGPA1_HUMANIntAct31413325 details
CLUS_HUMANKBP_HUMANIntAct31413325 details
CLUS_HUMANBEX3_HUMANIntAct31413325 details
CLUS_HUMANGOGA4_HUMANIntAct31413325 details
CLUS_HUMANHS90B_HUMANIntAct31413325 details
CLUS_HUMANGLDN_HUMANIntAct31413325 details
CLUS_HUMANCE85L_HUMANIntAct31413325 details
CLUS_HUMANPAX6_HUMANIntAct31413325 details
CLUS_HUMANARHG4_HUMANIntAct31413325 details
CLUS_HUMANCSN7A_HUMANIntAct31413325 details
CLUS_HUMANASB3_HUMANIntAct31413325 details
CLUS_HUMANPI42A_HUMANIntAct31413325 details
CLUS_HUMANNSD3_HUMANIntAct31413325 details
CLUS_HUMANINT10_HUMANIntAct31413325 details
CLUS_HUMANARGL1_HUMANIntAct31413325 details
CLUS_HUMANRN220_HUMANIntAct31413325 details
CLUS_HUMANPPP5_HUMANIntAct31413325 details
CLUS_HUMANKAP1_HUMANIntAct31413325 details
CLUS_HUMANDMAP1_HUMANIntAct31413325 details
CLUS_HUMANDCAF6_HUMANIntAct31413325 details
CLUS_HUMANRINT1_HUMANIntAct31413325 details
CLUS_HUMANPINK1_HUMANIntAct31413325 details
CLUS_HUMANSOS2_HUMANIntAct31413325 details
CLUS_HUMANDNJC7_HUMANIntAct31413325 details
CLUS_HUMANSYVC_HUMANIntAct31413325 details
CLUS_HUMANBRD3_HUMANIntAct31413325 details
CLUS_HUMANSPEF2_HUMANIntAct31413325 details
CLUS_HUMANQTRT2_HUMANIntAct31413325 details
CLUS_HUMANCEP63_HUMANIntAct31413325 details
CLUS_HUMANSPRL1_HUMANIntAct31413325 details
CLUS_HUMANZN514_HUMANIntAct31413325 details
CLUS_HUMANZN592_HUMANIntAct31413325 details
CLUS_HUMANVP9D1_HUMANIntAct31413325 details
CLUS_HUMANSYUA_HUMANBioGRID, IntAct28887769 31270237 details
CLUS_HUMANDLG4_HUMANMINT21653829 details
CLUS_HUMANSHAN3_HUMANMINT21653829 details
CLUS_HUMANMMP25_HUMANBioGRID, HPRD12860995 details
CLUS_HUMANNFKB1_HUMANBioGRID20068069 details
CLUS_HUMANIKBA_HUMANBioGRID20068069 details
CLUS_HUMANCUL1_HUMANBioGRID20068069 details
CLUS_HUMANFBW1A_HUMANBioGRID20068069 details
CLUS_HUMANIKKA_HUMANBioGRID20028970 details
CLUS_HUMANBAX_HUMANBioGRID16113678 19118032 19177010 21567405 23538443 details
CLUS_HUMANXPO1_HUMANBioGRID21953454 details
CLUS_HUMANB3AT_HUMANBioGRID22016805 details
CLUS_HUMANHBA_HUMANBioGRID22016805 details
CLUS_HUMANATP7B_HUMANBioGRID21242307 22130675 details
CLUS_HUMANATP7A_HUMANBioGRID21242307 details
CLUS_HUMANPON1_HUMANBioGRID, HPRD8292612 details
CLUS_HUMANBIP_HUMANBioGRID22689054 23457489 details
CLUS_HUMANHYOU1_HUMANBioGRID22689054 details
CLUS_HUMANTRFL_HUMANBioGRID17567961 details
CLUS_HUMANSEMG1_HUMANBioGRID17567961 details
CLUS_HUMANATG3_HUMANBioGRID25503391 details
CLUS_HUMANMLP3A_HUMANBioGRID25503391 details
CLUS_HUMANMMP9_HUMANBioGRID26716898 details
CLUS_HUMANVEGFA_HUMANBioGRID26716898 details
CLUS_HUMANMYCN_HUMANBioGRID26062444 details
CLUS_HUMANKDM1A_HUMANBioGRID26062444 details
CLUS_HUMANTAU_HUMANBioGRID25051234 details
CLUS_HUMANBIN1_HUMANBioGRID25051234 details
CLUS_HUMANLRP1B_HUMANBioGRID21420681 details
CLUS_HUMANTENA_HUMANBioGRID21349332 details
CLUS_HUMANVLDLR_HUMANHPRD12824284 details
CLUS_HUMANLRP8_HUMANHPRD12824284 details
CLUS_HUMANLEPR_HUMANHPRD12824284 details
CLUS_HUMANLEP_HUMANHPRD12824284 details