Entity Details

Primary name CDK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11802
EntryNameCDK4_HUMAN
FullNameCyclin-dependent kinase 4
TaxID9606
Evidenceevidence at protein level
Length303
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesCDK4

GO terms

Show/Hide Table
GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0002088 lens development in camera-type eye
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell population proliferation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0009636 response to toxic substance
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016592 mediator complex
GO:0030332 cyclin binding
GO:0030851 granulocyte differentiation
GO:0031100 animal organ regeneration
GO:0031965 nuclear membrane
GO:0032869 cellular response to insulin stimulus
GO:0033574 response to testosterone
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045727 positive regulation of translation
GO:0045787 positive regulation of cell cycle
GO:0045793 positive regulation of cell size
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046890 regulation of lipid biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0050994 regulation of lipid catabolic process
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060612 adipose tissue development
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:0097129 cyclin D2-CDK4 complex
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904628 cellular response to phorbol 13-acetate 12-myristate
GO:1904637 cellular response to ionomycin
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus
Nucleus membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB02733 PurvalanolDrugbanksmall molecule
DB03496 AlvocidibDrugbanksmall molecule
DB09073 PalbociclibDrugbanksmall molecule
DB11730 RibociclibDrugbanksmall molecule
DB12001 AbemaciclibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

177 interactions

InteractorPartnerSourcesPublicationsLink
CDK4_HUMANCDC37_HUMANBioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections11867521 17353931 21675959 21871133 24189400 24292678 24981860 25036637 26186194 27339980 28514442 8666233 8703009 9150368 details
CDK4_HUMANCDN2A_HUMANBioGRID, DIP, IntAct, MINT10022865 10491434 10580009 10585280 10719365 11556834 11900540 12529334 15065884 15232106 17353931 17517622 17881001 17909018 17955473 23455922 23602568 24855949 24981860 26186194 26496610 28042499 28205554 28218424 28514442 8259215 8805225 9228064 9529249 details
CDK4_HUMANCCND3_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10342870 11360184 11896535 14641107 15232106 16189514 16782892 16985050 19237555 21516116 21988832 23880157 25416956 25910212 26186194 26496610 27107012 28514442 30217970 31515488 32296183 33854235 9106657 9716181 details
CDK4_HUMANMCM2_HUMANBioGRID, HPRD, IntAct15232106 details
CDK4_HUMANCCND1_HUMANBioGRID, DIP, HPRD, I2D, IntAct10022865 10580009 10908655 11160398 11360184 11463845 12036906 12519773 15232106 16431923 16985050 17205132 17420273 18537972 19075005 19237565 19470470 19767775 20837141 21242975 21306487 21654808 23007395 23707388 23718855 24218572 24292678 24855949 25241761 25416956 25502805 25910212 26203195 27107012 27130439 28514442 29142209 31217276 31515488 33854235 7568034 8259215 8662825 8756624 8867812 8978686 9106657 9150368 9178893 9228064 9372967 9837900 details
CDK4_HUMANCDN1A_HUMANBioGRID, HPRD, IntAct, MINT10022865 11463845 12383116 15169570 15232106 15695403 16962592 17556661 18850315 20102411 23007395 23443559 28514442 30833792 8622677 8756624 9106657 9464540 9632134 9658399 details
CDK4_HUMANCDC7_HUMANBioGRID, HPRD, IntAct15232106 details
CDK4_HUMANCDN1C_HUMANBioGRID, HPRD, IntAct10713702 9106657 details
CDK4_HUMANCDN1B_HUMANBioGRID, DIP, HPRD, IntAct, MINT10022865 10198259 10908655 11360184 11940657 15695403 16326706 16782892 17053782 18285702 18615582 18850315 19470470 20837141 21439954 23602568 23707388 25241761 26186194 28514442 8978686 9106657 9311993 9464540 9632134 9658399 details
CDK4_HUMANZN655_HUMANBioGRID, HPRD, IntAct15558030 32296183 details
CDK4_HUMANCDN2B_HUMANBioGRID, HPRD, IntAct, MINT10022865 16169070 16189514 19447967 21900206 23455922 23602568 24981860 25910212 26186194 26496610 28205554 28514442 31515488 32296183 7478582 9111314 9163429 details
CDK4_HUMANCPNS1_HUMANBioGRID, HPRD, IntAct16169070 details
CDK4_HUMANBAG6_HUMANBioGRID, HPRD, IntAct16169070 17353931 details
CDK4_HUMANSETB1_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
CDK4_HUMANNOL12_HUMANHPRD, IntAct16169070 details
CDK4_HUMANCDN2D_HUMANBioGRID, HPRD, IntAct, MINT10022865 16189514 23602568 23718855 24981860 25416956 25910212 26186194 27107012 28514442 31515488 32296183 7739548 details
CDK4_HUMANVTA1_HUMANBioGRID, HPRD, IntAct16189514 details
CDK4_HUMANCCND2_HUMANBioGRID, HPRD, IntAct10022865 11360184 11896535 11971966 15169570 17873913 25910212 26186194 27107012 28205554 28514442 30217970 31515488 32296183 9178893 details
CDK4_HUMANCDN2C_HUMANBioGRID, HPRD, IntAct, MINT10022865 11900540 17353931 21988832 23455922 23602568 24981860 25416956 25910212 26186194 27107012 28205554 28514442 31515488 32296183 8001816 details
CDK4_HUMANPP1A_HUMANBioGRID, IntAct17274640 22939629 details
CDK4_HUMANPP1G_HUMANIntAct17274640 details
CDK4_HUMANMYC_HUMANBioGRID, IntAct21988832 22094256 24951594 28205554 details
CDK4_HUMANDUS9_HUMANBioGRID, IntAct21988832 details
CDK4_HUMANI15RA_HUMANBioGRID, IntAct21988832 details
CDK4_HUMANSKP1_HUMANBioGRID, IntAct21988832 details
CDK4_HUMANCIB1_HUMANBioGRID, IntAct21988832 details
CDK4_HUMANMARE2_HUMANBioGRID, IntAct21988832 details
CDK4_HUMAN6PGD_HUMANBioGRID, IntAct21988832 details
CDK4_HUMANANXA7_HUMANBioGRID, MINT21900206 details
CDK4_HUMANAPLP1_HUMANBioGRID, MINT21900206 details
CDK4_HUMANATPB_HUMANBioGRID, MINT21900206 details
CDK4_HUMANDDAH2_HUMANBioGRID, MINT21900206 details
CDK4_HUMANHMGX3_HUMANBioGRID, MINT21900206 details
CDK4_HUMANLC7L2_HUMANBioGRID, MINT21900206 details
CDK4_HUMANKPYM_HUMANBioGRID, MINT21900206 details
CDK4_HUMANSYQ_HUMANBioGRID, MINT21900206 details
CDK4_HUMANTRM2A_HUMANBioGRID, MINT21900206 details
CDK4_HUMANZBT16_HUMANBioGRID, MINT21900206 details
CDK4_HUMANDAZP2_HUMANBioGRID, MINT21900206 details
CDK4_HUMANSYUA_HUMANBioGRID, MINT21900206 details
CDK4_HUMANKITH_HUMANBioGRID, MINT21900206 details
CDK4_HUMANZN101_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANBC11A_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANFOXM1_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANOTX2_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANMZF1_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANSHOX2_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANZN219_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANCDC6_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANRBL1_HUMANBioGRID, HPRD, IntAct12006580 22094256 details
CDK4_HUMANSLBP_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANSENP3_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANRBL2_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANZN335_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANANR12_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANWDR33_HUMANBioGRID, IntAct22094256 details
CDK4_HUMANGLI1_HUMANBioGRID, IntAct22094256 26603838 details
CDK4_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
CDK4_HUMANHS90A_HUMANBioGRID, IntAct11867521 16611982 22315411 22939624 23455922 24292678 26186194 26804907 28514442 28537252 details
CDK4_HUMANCDK6_HUMANBioGRID, IntAct23455922 28205554 details
CDK4_HUMANSMAD3_HUMANBioGRID, HPRD, IntAct15241418 25241761 details
CDK4_HUMANHOOK1_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
CDK4_HUMANLNX2_HUMANBioGRID, IntAct27107012 details
CDK4_HUMANIKZF3_HUMANBioGRID, IntAct32296183 details
CDK4_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
CDK4_HUMANOGDHL_HUMANBioGRID, IntAct32296183 details
CDK4_HUMANCDK7_HUMANDIP16327805 details
CDK4_HUMANABC3B_HUMANIntAct31217276 details
CDK4_HUMANARF_HUMANBioGRID, HPRD10022865 10491434 10580009 10585280 10719365 11556834 11900540 12529334 15065884 15232106 17353931 17517622 17881001 17909018 23455922 23602568 24981860 26186194 26496610 28042499 28205554 28218424 28514442 8259215 8805225 9228064 9529249 details
CDK4_HUMANSRTD1_HUMANBioGRID, HPRD10580009 15065884 details
CDK4_HUMANCNOT7_HUMANBioGRID, HPRD10602502 30217970 details
CDK4_HUMANBRCA1_HUMANBioGRID, HPRD12509456 17334399 9244350 details
CDK4_HUMANCEBPA_HUMANBioGRID, HPRD11684017 11867521 15107404 details
CDK4_HUMANMYOD1_HUMANBioGRID, HPRD10022835 10601020 details
CDK4_HUMANRB_HUMANBioGRID, HPRD10198259 10202152 10486249 11254678 11287611 11306463 11900540 11971966 12190313 12509456 12519773 12676926 12949733 15003538 15147269 15169570 15241418 15695403 15922743 15998794 16205633 16326706 16878158 16962592 16985050 17015477 17053782 17873913 19225156 19556892 19767775 22094256 23543736 24292678 30833542 8449399 8626527 8647086 8756624 8867812 9003781 9139732 9190208 9199321 9315635 9464540 details
CDK4_HUMANNCOA2_HUMANBioGRID, HPRD12130539 details
CDK4_HUMANTSYL2_HUMANBioGRID11395479 details
CDK4_HUMANARI4A_HUMANBioGRID21148318 details
CDK4_HUMANH13_HUMANBioGRID18850315 details
CDK4_HUMANH11_HUMANBioGRID10447003 11132966 16431923 16878158 9464540 details
CDK4_HUMANMARCS_HUMANBioGRID10359664 details
CDK4_HUMANRL34_HUMANBioGRID10049762 details
CDK4_HUMANCCNE1_HUMANBioGRID28205554 9716181 details
CDK4_HUMANPSD10_HUMANBioGRID, HPRD11779854 11900540 17881001 details
CDK4_HUMANH10_HUMANBioGRID12383116 details
CDK4_HUMANA4_HUMANBioGRID21832049 details
CDK4_HUMANUBF1_HUMANBioGRID10202152 details
CDK4_HUMANDPOD1_HUMANBioGRID9545286 details
CDK4_HUMANSMAD2_HUMANBioGRID, HPRD15241418 details
CDK4_HUMANKCC1A_HUMANBioGRID23707388 details
CDK4_HUMANYBOX3_HUMANBioGRID10100871 details
CDK4_HUMANU17L2_HUMANBioGRID28067227 details
CDK4_HUMANPIAS1_HUMANBioGRID30217970 details
CDK4_HUMAN4EBP2_HUMANBioGRID30217970 details
CDK4_HUMANUBE3A_HUMANBioGRID29263404 details
CDK4_HUMANSPOP_HUMANBioGRID29160310 details
CDK4_HUMANCNTN2_HUMANBioGRID12779347 details
CDK4_HUMANP53_HUMANBioGRID28205554 28218424 details
CDK4_HUMANARAF_HUMANBioGRID28205554 details
CDK4_HUMANARNT_HUMANBioGRID28205554 details
CDK4_HUMANAKT1_HUMANBioGRID28205554 details
CDK4_HUMANCD44_HUMANBioGRID28205554 details
CDK4_HUMANCDK4_HUMANBioGRID28205554 details
CDK4_HUMANEPHA2_HUMANBioGRID28205554 details
CDK4_HUMANFGFR4_HUMANBioGRID28205554 details
CDK4_HUMANLATS2_HUMANBioGRID28205554 details
CDK4_HUMANSTK11_HUMANBioGRID28205554 details
CDK4_HUMANGLIS2_HUMANBioGRID28205554 details
CDK4_HUMANMP2K3_HUMANBioGRID28205554 details
CDK4_HUMANMP2K5_HUMANBioGRID28205554 details
CDK4_HUMANMERL_HUMANBioGRID28205554 details
CDK4_HUMANPGFRA_HUMANBioGRID28205554 details
CDK4_HUMANRAF1_HUMANBioGRID28205554 details
CDK4_HUMANBECN1_HUMANBioGRID28205554 details
CDK4_HUMANM3K5_HUMANBioGRID28205554 details
CDK4_HUMANTEAD2_HUMANBioGRID28205554 details
CDK4_HUMANTERT_HUMANBioGRID28205554 details
CDK4_HUMANTSC1_HUMANBioGRID28205554 details
CDK4_HUMANERBB2_HUMANBioGRID28205554 details
CDK4_HUMANFZR1_HUMANBioGRID28205554 details
CDK4_HUMANGRM1_HUMANBioGRID28205554 details
CDK4_HUMANHGF_HUMANBioGRID28205554 details
CDK4_HUMANHIF1A_HUMANBioGRID28205554 details
CDK4_HUMANIGF1R_HUMANBioGRID28205554 details
CDK4_HUMANERD22_HUMANBioGRID28205554 details
CDK4_HUMANMK14_HUMANBioGRID28205554 details
CDK4_HUMANMDM4_HUMANBioGRID28205554 details
CDK4_HUMANMET_HUMANBioGRID28205554 details
CDK4_HUMANRASF1_HUMANBioGRID28205554 details
CDK4_HUMANAGAP2_HUMANBioGRID30833542 details
CDK4_HUMANUBP51_HUMANBioGRID32296027 details
CDK4_HUMANCHIP_HUMANBioGRID29326975 details
CDK4_HUMANFBX8_HUMANBioGRID32796813 details
CDK4_HUMANASPM_HUMANBioGRID, IntAct17353931 26496610 details
CDK4_HUMANCRCM_HUMANIntAct17353931 details
CDK4_HUMANNU155_HUMANIntAct17353931 details
CDK4_HUMANCSTF3_HUMANIntAct17353931 details
CDK4_HUMANMMS19_HUMANIntAct17353931 details
CDK4_HUMANCOPB2_HUMANIntAct17353931 details
CDK4_HUMANMTFP1_HUMANIntAct17353931 details
CDK4_HUMANHS90B_HUMANBioGRID, IntAct22939624 23455922 26186194 28514442 details
CDK4_HUMANE2F4_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK4_HUMANTSC2_HUMANIntAct26977878 details
CDK4_HUMANDNJC9_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK4_HUMANKAT2A_HUMANDIP24870244 details
CDK4_HUMANPCNA_HUMANBioGRID11254741 8101826 8259215 details
CDK4_HUMANRFC1_HUMANBioGRID, HPRD10353443 details
CDK4_HUMANBIRC5_HUMANBioGRID, HPRD10713676 details
CDK4_HUMANSP1_HUMANBioGRID18769160 details
CDK4_HUMANCDT1_HUMANBioGRID15004027 details
CDK4_HUMANHSP7C_HUMANBioGRID18537972 details
CDK4_HUMANANM5_HUMANBioGRID20951943 details
CDK4_HUMANPSMD9_HUMANBioGRID12684681 details
CDK4_HUMANCD5R1_HUMANBioGRID22654103 details
CDK4_HUMANPSA6_HUMANBioGRID22158041 details
CDK4_HUMANCCNA2_HUMANBioGRID24302728 9716181 details
CDK4_HUMANUCHL1_HUMANBioGRID23543736 details
CDK4_HUMANPTMA_HUMANBioGRID, HPRD11310559 details
CDK4_HUMANTF65_HUMANBioGRID25331947 details
CDK4_HUMANFNIP1_HUMANBioGRID27353360 details
CDK4_HUMANFNIP2_HUMANBioGRID27353360 details
CDK4_HUMANGATA2_HUMANBioGRID17255359 details
CDK4_HUMANPAQR4_HUMANBioGRID28992327 details
CDK4_HUMANSKP2_HUMANBioGRID28992327 details
CDK4_HUMANFBX4_HUMANBioGRID28992327 details
CDK4_HUMANEGLN2_HUMANBioGRID26644182 details
CDK4_HUMANRFA2_HUMANBioGRID20679368 details
CDK4_HUMANRFA1_HUMANBioGRID20679368 details
CDK4_HUMANFBXL6_HUMANBioGRID31181401 details
CDK4_HUMANAAPK1_HUMANBioGRID30833542 details
CDK4_HUMANRFC4_HUMANHPRD10353443 details
CDK4_HUMANBMR1B_HUMANHPRD15761153 details
CDK4_HUMANTGFR1_HUMANHPRD15761153 details
CDK4_HUMANIFI27_HUMANHPRD9837900 details
CDK4_HUMANORC3_HUMANHPRD15232106 details
CDK4_HUMANCDC45_HUMANHPRD15232106 details
CDK4_HUMANKAP0_HUMANHPRD16582606 details