Entity Details

Primary name HARS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12081
EntryNameHARS1_HUMAN
FullNameHistidine--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length509
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesHARS1

GO terms

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GOName
GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006427 histidyl-tRNA aminoacylation
GO:0032543 mitochondrial translation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000738 WHEP-TRS domainDomainDomain
IPR004154 Anticodon-bindingDomainDomain
IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunitFamilyFamily
IPR006195 Aminoacyl-tRNA synthetase, class IIDomainDomain
IPR009068 S15/NS1, RNA-bindingFamilyHomologous superfamily
IPR015807 Histidine-tRNA ligaseFamilyFamily
IPR033656 Histidyl-anticodon-bindingDomainDomain
IPR036621 Anticodon-binding domain superfamilyFamilyHomologous superfamily
IPR041715 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00117 HistidineDrugbanksmall molecule