Entity Details

Primary name RARG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13631
EntryNameRARG_HUMAN
FullNameRetinoic acid receptor gamma
TaxID9606
Evidenceevidence at protein level
Length454
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesRARG

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001843 neural tube closure
GO:0002068 glandular epithelial cell development
GO:0003430 growth plate cartilage chondrocyte growth
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008361 regulation of cell size
GO:0009755 hormone-mediated signaling pathway
GO:0009952 anterior/posterior pattern specification
GO:0010628 positive regulation of gene expression
GO:0016021 integral component of membrane
GO:0030154 cell differentiation
GO:0031076 embryonic camera-type eye development
GO:0031641 regulation of myelination
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032526 response to retinoic acid
GO:0035116 embryonic hindlimb morphogenesis
GO:0035264 multicellular organism growth
GO:0043065 positive regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0045637 regulation of myeloid cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046965 retinoid X receptor binding
GO:0048048 embryonic eye morphogenesis
GO:0048384 retinoic acid receptor signaling pathway
GO:0060070 canonical Wnt signaling pathway
GO:0060324 face development
GO:0060534 trachea cartilage development
GO:0060740 prostate gland epithelium morphogenesis
GO:0070384 Harderian gland development
GO:0071300 cellular response to retinoic acid
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003078 Retinoic acid receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00210 AdapaleneDrugbanksmall molecule
DB00459 AcitretinDrugbanksmall molecule
DB00523 AlitretinoinDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00799 TazaroteneDrugbanksmall molecule
DB00926 EtretinateDrugbanksmall molecule
DB00982 IsotretinoinDrugbanksmall molecule
DB02258 SR11254Drugbanksmall molecule
DB02466 BMS-181156Drugbanksmall molecule
DB02741 CD564Drugbanksmall molecule
DB03279 Dodecyl-Alpha-D-MaltosideDrugbanksmall molecule
DB03466 BMS184394Drugbanksmall molecule
DB05467 R667Drugbanksmall molecule
DB05785 LGD-1550Drugbanksmall molecule
DB07031 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidDrugbanksmall molecule
DB07294 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acidDrugbanksmall molecule
DB12808 TrifaroteneDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
RARG_HUMANRM12_HUMANBioGRID, IntAct21988832 details
RARG_HUMANSPHK1_HUMANBioGRID, IntAct21988832 details
RARG_HUMANMTMR6_HUMANBioGRID, IntAct21988832 details
RARG_HUMANIL24_HUMANBioGRID, IntAct21988832 details
RARG_HUMANMS18B_HUMANBioGRID, IntAct21988832 details
RARG_HUMANLSR_HUMANBioGRID, IntAct21988832 details
RARG_HUMANZN576_HUMANBioGRID, IntAct21988832 details
RARG_HUMANRHPN2_HUMANBioGRID, IntAct21988832 details
RARG_HUMANACY3_HUMANBioGRID, IntAct21988832 details
RARG_HUMANITBP2_HUMANBioGRID, HPRD, IntAct15604093 25036637 details
RARG_HUMANRXRG_HUMANBioGRID, HPRD, IntAct1310259 15604093 32296183 details
RARG_HUMANKAP1_HUMANBioGRID, IntAct32296183 details
RARG_HUMANRXRB_HUMANBioGRID, HPRD, IntAct15604093 28514442 32296183 details
RARG_HUMANMYF5_HUMANBioGRID, IntAct32296183 details
RARG_HUMANBBS4_HUMANBioGRID, IntAct32296183 details
RARG_HUMANNCOR1_HUMANBioGRID10336495 details
RARG_HUMANNR2F6_HUMANBioGRID10318855 details
RARG_HUMANNCOR2_HUMANBioGRID, HPRD12665583 15604093 details
RARG_HUMANNCOA3_HUMANBioGRID, HPRD12665583 15604093 16456540 details
RARG_HUMANRXRA_HUMANBioGRID, HPRD15604093 9083083 details
RARG_HUMANPNRC1_HUMANBioGRID, HPRD15604093 details
RARG_HUMANPNRC2_HUMANBioGRID, HPRD15604093 details
RARG_HUMANNR0B2_HUMANBioGRID, HPRD15604093 details
RARG_HUMANMAP6_HUMANBioGRID, HPRD15604093 details
RARG_HUMANNCOA1_HUMANBioGRID, HPRD12665583 15604093 17363140 details
RARG_HUMANTNIP1_HUMANBioGRID19732752 details
RARG_HUMANNKX31_HUMANBioGRID18816836 details
RARG_HUMANARI1A_HUMANBioGRID17363140 details
RARG_HUMANSMRD3_HUMANBioGRID17363140 details
RARG_HUMANPRS8_HUMANBioGRID15604093 details
RARG_HUMANS10A3_HUMANBioGRID30532072 details
RARG_HUMANSMAD3_HUMANHPRD14603262 details
RARG_HUMANHMGA1_HUMANHPRD10428834 details
RARG_HUMANVINEX_HUMANMINT15734736 details
RARG_HUMANZN423_HUMANIntAct19345331 details
RARG_HUMANAJUBA_HUMANBioGRID20133701 details
RARG_HUMANSUZ12_HUMANBioGRID20857416 details
RARG_HUMANH2AZ_HUMANBioGRID20857416 details
RARG_HUMANHACE1_HUMANBioGRID19350571 details
RARG_HUMANYAP1_HUMANBioGRID27325643 details