Entity Details

Primary name PA2GA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14555
EntryNamePA2GA_HUMAN
FullNamePhospholipase A2, membrane associated
TaxID9606
Evidenceevidence at protein level
Length144
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesPLA2G2A

GO terms

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GOName
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006954 inflammatory response
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0016042 lipid catabolic process
GO:0019730 antimicrobial humoral response
GO:0019835 cytolysis
GO:0030141 secretory granule
GO:0034374 low-density lipoprotein particle remodeling
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0036335 intestinal stem cell homeostasis
GO:0046337 phosphatidylethanolamine metabolic process
GO:0046470 phosphatidylcholine metabolic process
GO:0046473 phosphatidic acid metabolic process
GO:0047498 calcium-dependent phospholipase A2 activity
GO:0048471 perinuclear region of cytoplasm
GO:0050482 arachidonic acid secretion
GO:0050729 positive regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
GO:1902563 regulation of neutrophil activation

Subcellular Location

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Subcellular Location
Cell membrane
Mitochondrion outer membrane
Secreted

Domains

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DomainNameCategoryType
IPR001211 Phospholipase A2FamilyFamily
IPR016090 Phospholipase A2 domainDomainDomain
IPR033112 Phospholipase A2, aspartic acid active siteSiteActive site
IPR033113 Phospholipase A2, histidine active siteSiteActive site
IPR036444 Phospholipase A2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00328 IndomethacinDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB01381 Ginkgo bilobaDrugbankbiotech
DB01955 1,4-ButanediolDrugbanksmall molecule
DB02080 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)BenzeneDrugbanksmall molecule
DB02448 N-Tridecanoic AcidDrugbanksmall molecule
DB02504 [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic AcidDrugbanksmall molecule
DB02936 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric AcidDrugbanksmall molecule
DB03017 Lauric acidDrugbanksmall molecule
DB03121 (1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acidDrugbanksmall molecule
DB03471 6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acidDrugbanksmall molecule
DB03784 ElaidamideDrugbanksmall molecule
DB04112 (2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphateDrugbanksmall molecule
DB04287 KH064Drugbanksmall molecule
DB04786 SuraminDrugbanksmall molecule
DB05737 Varespladib methylDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
PA2GA_HUMANDPYL1_HUMANHPRD, IntAct16169070 details
PA2GA_HUMANCREL2_HUMANMINT21900206 details
PA2GA_HUMANCEP70_HUMANBioGRID, MINT21900206 details
PA2GA_HUMANPA21B_HUMANBioGRID, HPRD7721806 details
PA2GA_HUMANPGS2_HUMANBioGRID, HPRD10747008 details
PA2GA_HUMANBAG6_HUMANBioGRID21900206 details
PA2GA_HUMANVIME_HUMANBioGRID12829607 details
PA2GA_HUMANUCHL5_HUMANBioGRID22118674 details
PA2GA_HUMANUCHL3_HUMANBioGRID22118674 details
PA2GA_HUMANUBP8_HUMANBioGRID22118674 details
PA2GA_HUMANUBP7_HUMANBioGRID22118674 details
PA2GA_HUMANUBP5_HUMANBioGRID22118674 details
PA2GA_HUMANUBP47_HUMANBioGRID22118674 details
PA2GA_HUMANUBP4_HUMANBioGRID22118674 details
PA2GA_HUMANUBP28_HUMANBioGRID22118674 details
PA2GA_HUMANUBP20_HUMANBioGRID22118674 details
PA2GA_HUMANUBP2_HUMANBioGRID22118674 details
PA2GA_HUMANUBP15_HUMANBioGRID22118674 details
PA2GA_HUMANUCHL1_HUMANBioGRID22118674 details
PA2GA_HUMANSENP6_HUMANBioGRID22118674 details
PA2GA_HUMANJOS2_HUMANBioGRID22118674 details
PA2GA_HUMANSENP8_HUMANBioGRID22118674 details
PA2GA_HUMANITAV_HUMANBioGRID18635536 details
PA2GA_HUMANITB3_HUMANBioGRID18635536 details
PA2GA_HUMANLOX12_HUMANBioGRID, HPRD, MINT15474031 details
PA2GA_HUMANPA2GA_HUMANBioGRID, HPRD12616631 15299314 1948070 8831753 details
PA2GA_HUMANTGM2_HUMANBioGRID23913269 details
PA2GA_HUMANEGFR_HUMANBioGRID28440478 details
PA2GA_HUMANERBB2_HUMANBioGRID28440478 details
PA2GA_HUMANERBB3_HUMANBioGRID28440478 details
PA2GA_HUMANPLA2R_HUMANHPRD7721806 details
PA2GA_HUMANCSPG2_HUMANHPRD8824283 9848887 details