Entity Details

Primary name QCR7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14927
EntryNameQCR7_HUMAN
FullNameCytochrome b-c1 complex subunit 7
TaxID9606
Evidenceevidence at protein level
Length111
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesUQCRB

GO terms

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GOName
GO:0005743 mitochondrial inner membrane
GO:0005746 mitochondrial respirasome
GO:0005750 mitochondrial respiratory chain complex III
GO:0006119 oxidative phosphorylation
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0009060 aerobic respiration

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR003197 Cytochrome b-c1 complex subunit 7FamilyFamily
IPR036544 Cytochrome b-c1 complex subunit 7 superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615158 OMIMMitochondrial complex III deficiency, nuclear 3 (MC3DN3)A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04141 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolDrugbanksmall molecule
DB04799 6-Hydroxy-5-undecyl-4,7-benzothiazoledioneDrugbanksmall molecule
DB07401 AzoxystrobinDrugbanksmall molecule
DB07636 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dioneDrugbanksmall molecule
DB07763 (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONEDrugbanksmall molecule
DB07778 (S)-famoxadoneDrugbanksmall molecule
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATEDrugbanksmall molecule
DB08453 2-Nonyl-4-quinolinol 1-oxideDrugbanksmall molecule
DB08690 Ubiquinone Q2Drugbanksmall molecule