Entity Details

Primary name VEGFA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15692
EntryNameVEGFA_HUMAN
FullNameVascular endothelial growth factor A
TaxID9606
Evidenceevidence at protein level
Length232
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesVEGFA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001968 fibronectin binding
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002092 positive regulation of receptor internalization
GO:0002575 basophil chemotaxis
GO:0002576 platelet degranulation
GO:0002687 positive regulation of leukocyte migration
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003169 coronary vein morphogenesis
GO:0005125 cytokine activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005172 vascular endothelial growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005912 adherens junction
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0007498 mesoderm development
GO:0007595 lactation
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010749 regulation of nitric oxide mediated signal transduction
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0030141 secretory granule
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030855 epithelial cell differentiation
GO:0031012 extracellular matrix
GO:0031077 post-embryonic camera-type eye development
GO:0031093 platelet alpha granule lumen
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031954 positive regulation of protein autophosphorylation
GO:0032147 activation of protein kinase activity
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035148 tube formation
GO:0035767 endothelial cell chemotaxis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036303 lymph vessel morphogenesis
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190 VEGF-activated neuropilin signaling pathway
GO:0038191 neuropilin binding
GO:0042056 chemoattractant activity
GO:0042327 positive regulation of phosphorylation
GO:0042462 eye photoreceptor cell development
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043117 positive regulation of vascular permeability
GO:0043129 surfactant homeostasis
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043183 vascular endothelial growth factor receptor 1 binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048018 receptor ligand activity
GO:0048469 cell maturation
GO:0048593 camera-type eye morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048844 artery morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050840 extracellular matrix binding
GO:0050918 positive chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051272 positive regulation of cellular component movement
GO:0051781 positive regulation of cell division
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060319 primitive erythrocyte differentiation
GO:0060749 mammary gland alveolus development
GO:0060754 positive regulation of mast cell chemotaxis
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060982 coronary artery morphogenesis
GO:0061042 vascular wound healing
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:0071679 commissural neuron axon guidance
GO:0090037 positive regulation of protein kinase C signaling
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259 regulation of retinal ganglion cell axon guidance
GO:0097475 motor neuron migration
GO:0097533 cellular stress response to acid chemical
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745 positive regulation of p38MAPK cascade
GO:1901165 positive regulation of trophoblast cell migration
GO:1901727 positive regulation of histone deacetylase activity
GO:1902336 positive regulation of retinal ganglion cell axon guidance
GO:1902966 positive regulation of protein localization to early endosome
GO:1903141 negative regulation of establishment of endothelial barrier
GO:1903392 negative regulation of adherens junction organization
GO:1903572 positive regulation of protein kinase D signaling
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903672 positive regulation of sprouting angiogenesis
GO:1905278 positive regulation of epithelial tube formation
GO:1905604 negative regulation of blood-brain barrier permeability
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000072 PDGF/VEGF domainDomainDomain
IPR023581 Platelet-derived growth factor, conserved siteSiteConserved site
IPR027928 Vascular endothelial growth factor, heparin-binding domainDomainDomain
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily
IPR036841 Vascular endothelial growth factor, heparin-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00112 BevacizumabDrugbankbiotech
DB01017 MinocyclineDrugbanksmall molecule
DB01120 GliclazideDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01270 RanibizumabDrugbankbiotech
DB03088 Pidolic acidDrugbanksmall molecule
DB04895 PegaptanibDrugbankbiotech
DB05294 VandetanibDrugbanksmall molecule
DB05434 ABT-510Drugbanksmall molecule
DB05890 VeglinDrugbanksmall molecule
DB05932 DenibulinDrugbanksmall molecule
DB05969 SNS-032Drugbanksmall molecule
DB06642 BevasiranibDrugbankbiotech
DB06779 DalteparinDrugbanksmall molecule
DB08885 AfliberceptDrugbankbiotech
DB09301 Chondroitin sulfateDrugbanksmall molecule
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB14864 BrolucizumabDrugbankbiotech
DB15303 FaricimabDrugbankbiotech

Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
VEGFA_HUMANVGFR2_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct, matrixdb, MINT12716911 1417831 16423422 16763549 16901919 17318185 18325345 19818105 20145116 20660291 21596751 22897854 23374253 23583373 25644401 28303365 30236477 31932617 8621427 details
VEGFA_HUMANNRP1_HUMANBioGRID, HPRD, IntAct, MINT10409677 11886873 11986311 16423422 16763549 17222790 18325345 20363638 21939755 22318724 22897854 26804163 30236477 9529250 details
VEGFA_HUMANVGFR1_HUMANbhf-ucl, BioGRID, HPRD, IntAct, matrixdb10543948 1312256 17051153 18593464 20660291 21596751 21939755 28514442 8621427 9393862 details
VEGFA_HUMANU2AF1_HUMANBioGRID, IntAct21988832 details
VEGFA_HUMANVPS35_HUMANBioGRID, IntAct21988832 details
VEGFA_HUMANTMG4_HUMANBioGRID, IntAct21988832 details
VEGFA_HUMANHIF1A_HUMANBioGRID, I2D, IntAct11901189 17413038 21602890 21620138 22952674 23549086 23928995 23991099 24434214 24656772 details
VEGFA_HUMANVEGFA_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT10748121 12086892 12207021 1312256 22897854 25132001 30236477 8631822 9207067 details
VEGFA_HUMANUBIA1_HUMANBioGRID, UniProt23169578 details
VEGFA_HUMANNGAL_HUMANIntAct32296183 details
VEGFA_HUMANCXB1_HUMANBioGRID, IntAct32296183 details
VEGFA_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
VEGFA_HUMANTM237_HUMANBioGRID, IntAct32296183 details
VEGFA_HUMANATS1_HUMANBioGRID, HPRD12716911 details
VEGFA_HUMANCCN2_HUMANBioGRID, HPRD11744618 details
VEGFA_HUMANIBP7_HUMANBioGRID, HPRD12407018 details
VEGFA_HUMANSPRC_HUMANBioGRID, HPRD25921830 9792673 details
VEGFA_HUMANVTNC_HUMANBioGRID, HPRD11796824 details
VEGFA_HUMANGPC1_HUMANBioGRID, HPRD10196157 details
VEGFA_HUMANCRYAB_HUMANBioGRID17487982 21984182 details
VEGFA_HUMANLYVE1_HUMANBioGRID7829517 details
VEGFA_HUMANU2AF5_HUMANBioGRID21988832 details
VEGFA_HUMANNRP2_HUMANBioGRID, HPRD10748121 17595163 details
VEGFA_HUMANFINC_HUMANBioGRID12114318 details
VEGFA_HUMANSP1_HUMANBioGRID15342781 details
VEGFA_HUMANSP3_HUMANBioGRID15342781 details
VEGFA_HUMANAP2A_HUMANBioGRID15342781 details
VEGFA_HUMANMOT8_HUMANBioGRID32296183 details
VEGFA_HUMANVEGFB_HUMANBioGRID, HPRD, IntAct25241761 26186194 28514442 8702615 details
VEGFA_HUMANPLGF_HUMANBioGRID, HPRD, IntAct12086892 12796773 25241761 details
VEGFA_HUMANSTAT3_HUMANBioGRID, IntAct23750211 23991099 details
VEGFA_HUMANTSP1_HUMANDIP19805200 details
VEGFA_HUMANHS90A_HUMANBioGRID18211808 details
VEGFA_HUMANHSP74_HUMANBioGRID18211808 23109422 details
VEGFA_HUMANHGS_HUMANBioGRID17445799 details
VEGFA_HUMANPTPRB_HUMANBioGRID25644401 details
VEGFA_HUMANPTPRZ_HUMANBioGRID25644401 details
VEGFA_HUMANCLUS_HUMANBioGRID26716898 details
VEGFA_HUMANUSF2_HUMANBioGRID23991099 details
VEGFA_HUMANFOS_HUMANBioGRID23549086 details
VEGFA_HUMANARNT_HUMANBioGRID17413038 25879517 details
VEGFA_HUMANSEM3F_HUMANHPRD12845630 details
VEGFA_HUMANTENX_HUMANHPRD11122379 details
VEGFA_HUMANEPHB2_HUMANHPRD17318185 details
VEGFA_HUMANAKT1_HUMANHPRD17318185 details
VEGFA_HUMANYBOX3_HUMANHPRD16198352 details
VEGFA_HUMANYBOX1_HUMANHPRD16198352 details