Entity Details

Primary name NCPR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16435
EntryNameNCPR_HUMAN
FullNameNADPH--cytochrome P450 reductase
TaxID9606
Evidenceevidence at protein level
Length677
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesPOR

GO terms

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GOName
GO:0003958 NADPH-hemoprotein reductase activity
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006805 xenobiotic metabolic process
GO:0009725 response to hormone
GO:0010181 FMN binding
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0022900 electron transport chain
GO:0032770 positive regulation of monooxygenase activity
GO:0043231 intracellular membrane-bounded organelle
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0090346 cellular organofluorine metabolic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001094 Flavodoxin-likeDomainDomain
IPR001433 Oxidoreductase FAD/NAD(P)-bindingDomainDomain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductaseDomainDomain
IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-bindingDomainDomain
IPR008254 Flavodoxin/nitric oxide synthaseDomainDomain
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR023208 NADPH-cytochrome P450 reductaseFamilyFamily
IPR029039 Flavoprotein-like superfamilyFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00166 Lipoic acidDrugbanksmall molecule
DB00305 MitomycinSwissprotsmall molecule
DB00665 NilutamideDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00698 NitrofurantoinDrugbanksmall molecule
DB00865 BenzphetamineDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01466 EthylmorphineDrugbanksmall molecule
DB03147 Flavin adenine dinucleotideDrugbanksmall molecule
DB03247 Flavin mononucleotideDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB06263 AmrubicinDrugbanksmall molecule
DB09332 KappadioneDrugbanksmall molecule