Entity Details

Primary name FER_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16591
EntryNameFER_HUMAN
FullNameTyrosine-protein kinase Fer
TaxID9606
Evidenceevidence at protein level
Length822
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesFER

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0001932 regulation of protein phosphorylation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005154 epidermal growth factor receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005938 cell cortex
GO:0006468 protein phosphorylation
GO:0006935 chemotaxis
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0008157 protein phosphatase 1 binding
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0008289 lipid binding
GO:0010591 regulation of lamellipodium assembly
GO:0010762 regulation of fibroblast migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030054 cell junction
GO:0030154 cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031532 actin cytoskeleton reorganization
GO:0032496 response to lipopolysaccharide
GO:0032869 cellular response to insulin stimulus
GO:0033007 negative regulation of mast cell activation involved in immune response
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034614 cellular response to reactive oxygen species
GO:0035426 extracellular matrix-cell signaling
GO:0035556 intracellular signal transduction
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0036119 response to platelet-derived growth factor
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038109 Kit signaling pathway
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042995 cell projection
GO:0043304 regulation of mast cell degranulation
GO:0044331 cell-cell adhesion mediated by cadherin
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0050904 diapedesis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070102 interleukin-6-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001060 FCH domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016250 Tyrosine-protein kinase, Fes/Fps typeFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027267 AH/BAR domain superfamilyFamilyHomologous superfamily
IPR028539 Tyrosine-protein kinase FerFamilyFamily
IPR031160 F-BAR domainDomainDomain
IPR035849 Fes/Fps/Fer, SH2 domainDomainDomain
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR037452 Tyrosine-protein kinase Fer, F-BAR domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
FER_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
FER_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
FER_HUMANABI1_HUMANMINT20598684 details
FER_HUMANNSF_HUMANMINT15322554 details
FER_HUMANKCTD4_HUMANBioGRID, IntAct25814554 details
FER_HUMANP55G_HUMANBioGRID, IntAct25814554 details
FER_HUMANPP1R7_HUMANBioGRID, IntAct25814554 details
FER_HUMANCRK_HUMANBioGRID, IntAct25814554 details
FER_HUMANP85A_HUMANBioGRID, IntAct25814554 details
FER_HUMANTMF1_HUMANBioGRID, HPRD9742951 details
FER_HUMANCTNB1_HUMANBioGRID, HPRD12640114 details
FER_HUMANCADH1_HUMANBioGRID12640114 details
FER_HUMANSRC8_HUMANBioGRID, HPRD10921917 9722593 9748248 details
FER_HUMANFER_HUMANBioGRID, HPRD10998246 17192257 26702831 9722593 details
FER_HUMANHS90B_HUMANIntAct22939624 details
FER_HUMANCDC37_HUMANBioGRID, IntAct25036637 details
FER_HUMANDYN1_HUMANBioGRID9722593 details
FER_HUMANDYN2_HUMANBioGRID9722593 details
FER_HUMANDYN3_HUMANBioGRID9722593 details
FER_HUMANEGFR_HUMANBioGRID, HPRD18271526 7623846 details
FER_HUMANHS90A_HUMANBioGRID22939624 details
FER_HUMANCTND1_HUMANHPRD12640114 details
FER_HUMAN1433B_HUMANHPRD15324660 details
FER_HUMANCALM1_HUMANHPRD10411641 3350007 3472906 details
FER_HUMANCALM2_HUMANHPRD10411641 3350007 3472906 details
FER_HUMANCALM3_HUMANHPRD10411641 3350007 3472906 details
FER_HUMANSTAT3_HUMANHPRD10878010 12738762 details
FER_HUMANPLAK_HUMANHPRD14517306 details
FER_HUMANIRS1_HUMANHPRD11006284 details
FER_HUMANJAK1_HUMANHPRD12738762 details