Entity Details

Primary name PLCG2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16885
EntryNamePLCG2_HUMAN
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
TaxID9606
Evidenceevidence at protein level
Length1265
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesPLCG2

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002092 positive regulation of receptor internalization
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002316 follicular B cell differentiation
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006661 phosphatidylinositol biosynthetic process
GO:0009395 phospholipid catabolic process
GO:0010628 positive regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0016055 Wnt signaling pathway
GO:0019722 calcium-mediated signaling
GO:0019901 protein kinase binding
GO:0030168 platelet activation
GO:0030183 B cell differentiation
GO:0032237 activation of store-operated calcium channel activity
GO:0032481 positive regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0032959 inositol trisphosphate biosynthetic process
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043069 negative regulation of programmed cell death
GO:0043647 inositol phosphate metabolic process
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051209 release of sequestered calcium ion into cytosol
GO:0070062 extracellular exosome
GO:0071277 cellular response to calcium ion
GO:0097110 scaffold protein binding
GO:0140031 phosphorylation-dependent protein binding
GO:1902808 positive regulation of cell cycle G1/S phase transition

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001452 SH3 domainDomainDomain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gammaFamilyFamily
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR028381 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2FamilyFamily
IPR035023 PLC-gamma, C-terminal SH2 domainDomainDomain
IPR035024 PLC-gamma, N-terminal SH2 domainDomainDomain
IPR035723 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614878 OMIMAutoinflammation, antibody deficiency, and immune dysregulation (APLAID)An autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including joints, the eye, and the gastrointestinal tract. Affected individuals have a mild humoral immune deficiency associated with recurrent sinopulmonary infections, but no evidence of circulating autoantibodies. The disease is caused by variants affecting the gene represented in this entry.
614468 OMIMFamilial cold autoinflammatory syndrome 3 (FCAS3)An autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased numbers of B-cells, defective B-cells, increased susceptibility to infection, and increased risk of autoimmune disorders. The disease is caused by variants affecting the gene represented in this entry.

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
PLCG2_HUMANEPOR_HUMANHPRD, IntAct15644415 15953601 details
PLCG2_HUMANZ512B_HUMANBioGRID, MINT15231748 details
PLCG2_HUMANEGFR_HUMANBioGRID, IntAct, MINT16273093 22973453 24658140 25241761 25402006 31980649 details
PLCG2_HUMANERBB2_HUMANBioGRID, IntAct, MINT16273093 22973453 25241761 details
PLCG2_HUMANGRB2_HUMANIntAct17474147 details
PLCG2_HUMANP85A_HUMANBioGRID, IntAct17474147 25241761 details
PLCG2_HUMANMED28_HUMANMINT16964398 details
PLCG2_HUMANANDR_HUMANBioGRID, IntAct24728074 details
PLCG2_HUMANGAB1_HUMANBioGRID, HPRD, IntAct11507676 24728074 details
PLCG2_HUMANKIT_HUMANBioGRID, IntAct24728074 details
PLCG2_HUMANMET_HUMANBioGRID, IntAct24728074 details
PLCG2_HUMANEPYC_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANLHX8_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANELK1_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANCH60_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANP53_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANPTTG1_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANKCD17_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANBOP_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANZKSC7_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANASB9_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANTWST2_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANGABP2_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANSETD9_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANRBP1_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANISL1_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANESTD_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANFSBP_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANPSMD3_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANCD244_HUMANUniProt24642916 details
PLCG2_HUMANSH21B_HUMANUniProt24642916 details
PLCG2_HUMANLAT_HUMANBioGRID, HPRD, UniProt10469124 24642916 27221712 details
PLCG2_HUMANLYN_HUMANBioGRID, HPRD10981967 12181444 15144186 7682059 8395016 details
PLCG2_HUMANFYN_HUMANBioGRID, HPRD12181444 15144186 7682059 8395016 details
PLCG2_HUMANBLK_HUMANBioGRID, HPRD8395016 details
PLCG2_HUMANIRS1_HUMANBioGRID22974441 details
PLCG2_HUMANRA54B_HUMANBioGRID25814554 details
PLCG2_HUMANPTN6_HUMANBioGRID27221712 details
PLCG2_HUMANCD19_HUMANBioGRID, HPRD10706702 15187135 details
PLCG2_HUMANERBB3_HUMANBioGRID22973453 details
PLCG2_HUMANERBB4_HUMANBioGRID22973453 details
PLCG2_HUMANVGFR1_HUMANHPRD9398617 details
PLCG2_HUMAN3BP2_HUMANHPRD, MINT11390470 details
PLCG2_HUMANBLNK_HUMANBioGRID, HPRD, MINT11274146 21822214 details
PLCG2_HUMANEPHA4_HUMANIntAct31413325 details
PLCG2_HUMANSHC1_HUMANBioGRID, HPRD10623845 12135708 details
PLCG2_HUMANGAB2_HUMANBioGRID, HPRD12135708 details
PLCG2_HUMANPTN11_HUMANBioGRID12135708 details
PLCG2_HUMANKPCD1_HUMANBioGRID, HPRD8885868 details
PLCG2_HUMANBTK_HUMANBioGRID, HPRD10981967 11507089 12093870 17290227 details
PLCG2_HUMANCBLB_HUMANBioGRID, HPRD12093870 details
PLCG2_HUMANNTAL_HUMANBioGRID, HPRD12514734 details
PLCG2_HUMANVAV_HUMANBioGRID10981967 details
PLCG2_HUMANKSYK_HUMANBioGRID, HPRD10933389 10981967 12470302 12771181 details
PLCG2_HUMANPLXB1_HUMANBioGRID19805522 details
PLCG2_HUMANKPCA_HUMANBioGRID16923831 details
PLCG2_HUMANPLD1_HUMANBioGRID16923831 details
PLCG2_HUMANBCAP_HUMANBioGRID27909057 details
PLCG2_HUMANTAU_HUMANBioGRID9592050 details
PLCG2_HUMANVGFR2_HUMANHPRD9398617 details
PLCG2_HUMANLCP2_HUMANHPRD10469124 details
PLCG2_HUMANKHDR1_HUMANHPRD10467411 details
PLCG2_HUMANPLCG2_HUMANHPRD9819383 details
PLCG2_HUMANNPM_HUMANHPRD9819383 details
PLCG2_HUMANJAK1_HUMANHPRD14978237 details
PLCG2_HUMANJAK2_HUMANHPRD14978237 details
PLCG2_HUMANITK_HUMANHPRD15184383 details
PLCG2_HUMANTEC_HUMANHPRD15184383 details
PLCG2_HUMANDAPP1_HUMANHPRD10770799 details
PLCG2_HUMANLIME1_HUMANHPRD16249387 details
PLCG2_HUMANFCERG_HUMANHPRD10469124 details
PLCG2_HUMANHCK_HUMANHPRD12181444 15144186 7682059 details
PLCG2_HUMANLCK_HUMANHPRD12181444 15144186 7682059 details