Entity Details

Primary name ACHB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17787
EntryNameACHB2_HUMAN
FullNameNeuronal acetylcholine receptor subunit beta-2
TaxID9606
Evidenceevidence at protein level
Length502
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesCHRNB2

GO terms

Show/Hide Table
GOName
GO:0001666 response to hypoxia
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0007271 synaptic transmission, cholinergic
GO:0007601 visual perception
GO:0007605 sensory perception of sound
GO:0007612 learning
GO:0007613 memory
GO:0007626 locomotory behavior
GO:0008306 associative learning
GO:0008542 visual learning
GO:0009897 external side of plasma membrane
GO:0014059 regulation of dopamine secretion
GO:0015276 ligand-gated ion channel activity
GO:0015464 acetylcholine receptor activity
GO:0016021 integral component of membrane
GO:0019233 sensory perception of pain
GO:0021562 vestibulocochlear nerve development
GO:0021631 optic nerve morphogenesis
GO:0021771 lateral geniculate nucleus development
GO:0021952 central nervous system projection neuron axonogenesis
GO:0022848 acetylcholine-gated cation-selective channel activity
GO:0030594 neurotransmitter receptor activity
GO:0030890 positive regulation of B cell proliferation
GO:0032225 regulation of synaptic transmission, dopaminergic
GO:0033603 positive regulation of dopamine secretion
GO:0034220 ion transmembrane transport
GO:0035094 response to nicotine
GO:0035095 behavioral response to nicotine
GO:0035176 social behavior
GO:0042053 regulation of dopamine metabolic process
GO:0042113 B cell activation
GO:0042166 acetylcholine binding
GO:0042220 response to cocaine
GO:0042320 regulation of circadian sleep/wake cycle, REM sleep
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0044853 plasma membrane raft
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0045471 response to ethanol
GO:0045759 negative regulation of action potential
GO:0048814 regulation of dendrite morphogenesis
GO:0050877 nervous system process
GO:0050890 cognition
GO:0051899 membrane depolarization
GO:0051963 regulation of synapse assembly
GO:0060084 synaptic transmission involved in micturition
GO:0095500 acetylcholine receptor signaling pathway
GO:1905144 response to acetylcholine

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR002394 Nicotinic acetylcholine receptorFamilyFamily
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR032932 Neuronal acetylcholine receptor subunit beta-2FamilyFamily
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00184 NicotineDrugbanksmall molecule
DB00237 ButabarbitalDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00572 AtropineDrugbanksmall molecule
DB00657 MecamylamineDrugbanksmall molecule
DB00747 ScopolamineDrugbanksmall molecule
DB00753 IsofluraneDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB00981 PhysostigmineDrugbanksmall molecule
DB01245 DecamethoniumDrugbanksmall molecule
DB01273 VareniclineDrugbanksmall molecule
DB05458 PozaniclineDrugbanksmall molecule
DB05740 RPI-78MDrugbanksmall molecule
DB05855 RivaniclineDrugbanksmall molecule
DB07720 EpibatidineDrugbanksmall molecule
DB09028 CytisineDrugbanksmall molecule