Entity Details

Primary name VGFR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17948
EntryNameVGFR1_HUMAN
FullNameVascular endothelial growth factor receptor 1
TaxID9606
Evidenceevidence at protein level
Length1338
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesFLT1

GO terms

Show/Hide Table
GOName
GO:0001525 angiogenesis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002548 monocyte chemotaxis
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015629 actin cytoskeleton
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0030335 positive regulation of cell migration
GO:0033674 positive regulation of kinase activity
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036323 vascular endothelial growth factor receptor-1 signaling pathway
GO:0036332 placental growth factor-activated receptor activity
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0048598 embryonic morphogenesis
GO:1905563 negative regulation of vascular endothelial cell proliferation
GO:1990384 hyaloid vascular plexus regression

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm
Endosome
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009135 Vascular endothelial growth factor receptor 1 (VEGFR1)FamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041348 VEGFR-2, Transmembrane domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB04879 VatalanibDrugbanksmall molecule
DB05075 TG-100801Drugbanksmall molecule
DB05913 OSI-930Drugbanksmall molecule
DB05932 DenibulinDrugbanksmall molecule
DB06080 ABT-869Drugbanksmall molecule
DB06101 IMC-1C11Drugbankbiotech
DB06589 PazopanibDrugbanksmall molecule
DB06626 AxitinibDrugbanksmall molecule
DB07288 N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamideDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule
DB15685 SelpercatinibDrugbanksmall molecule

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
VGFR1_HUMANVEGFA_HUMANbhf-ucl, BioGRID, HPRD, IntAct, matrixdb10543948 1312256 17051153 18593464 20660291 21596751 21939755 28514442 8621427 9393862 details
VGFR1_HUMANPLGF_HUMANbhf-ucl, BioGRID, HPRD, IntAct14684734 20660291 9452434 details
VGFR1_HUMANCBL_HUMANBioGRID, MINT18273061 25387128 details
VGFR1_HUMANPTPRJ_HUMANMINT12771128 16893970 details
VGFR1_HUMANP85A_HUMANBioGRID, IntAct, MINT20805333 23397142 7657594 details
VGFR1_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
VGFR1_HUMANPLCG1_HUMANBioGRID, HPRD, IntAct11312102 23397142 9299537 9398617 9600074 details
VGFR1_HUMANPTN11_HUMANBioGRID, HPRD, IntAct23397142 25241761 9600074 details
VGFR1_HUMANPGBM_HUMANmatrixdb21596751 details
VGFR1_HUMANSHC1_HUMANBioGRID, HPRD10749680 details
VGFR1_HUMANVGFR2_HUMANBioGRID, HPRD10865839 12796773 25387128 details
VGFR1_HUMANVEGFB_HUMANBioGRID, HPRD10409677 9751730 details
VGFR1_HUMANSHC2_HUMANBioGRID10749680 9790910 details
VGFR1_HUMANNEDD4_HUMANBioGRID19953087 details
VGFR1_HUMANVGFR1_HUMANBioGRID, HPRD11513746 7657594 details
VGFR1_HUMANPLCG2_HUMANHPRD9398617 details
VGFR1_HUMANATR_HUMANHPRD10749680 details
VGFR1_HUMANNCK1_HUMANHPRD9600074 details
VGFR1_HUMANLDLR_HUMANMINT17962812 details
VGFR1_HUMANPTPRB_HUMANMINT22016384 details
VGFR1_HUMANROBO4_HUMANIntAct23063127 details
VGFR1_HUMANCRK_HUMANHPRD, IntAct23397142 9722576 details
VGFR1_HUMANCTNB1_HUMANHPRD, IntAct12920240 23397142 details
VGFR1_HUMANFAK1_HUMANIntAct23397142 details
VGFR1_HUMANHCK_HUMANIntAct23397142 details
VGFR1_HUMANCRKL_HUMANIntAct23397142 details
VGFR1_HUMANNRP1_HUMANHPRD, IntAct10842181 23452854 details
VGFR1_HUMANLEG1_HUMANIntAct24529377 details
VGFR1_HUMANEEA1_HUMANIntAct23799140 details
VGFR1_HUMANFYN_HUMANHPRD, UniProt12509223 details
VGFR1_HUMANYES_HUMANHPRD, UniProt12509223 details
VGFR1_HUMANMICA2_HUMANBioGRID25601765 details
VGFR1_HUMANMICLK_HUMANBioGRID25601765 details
VGFR1_HUMANNRP2_HUMANHPRD11278319 details
VGFR1_HUMANGRB2_HUMANHPRD9722576 details
VGFR1_HUMANSTAT1_HUMANHPRD15703780 details
VGFR1_HUMANSTAT3_HUMANHPRD15703780 details
VGFR1_HUMANFAK2_HUMANHPRD11751905 details