Entity Details

Primary name NFKB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19838
EntryNameNFKB1_HUMAN
FullNameNuclear factor NF-kappa-B p105 subunit
TaxID9606
Evidenceevidence at protein level
Length968
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesNFKB1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0008134 transcription factor binding
GO:0010629 negative regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010884 positive regulation of lipid storage
GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
GO:0010957 negative regulation of vitamin D biosynthetic process
GO:0019899 enzyme binding
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032375 negative regulation of cholesterol transport
GO:0032481 positive regulation of type I interferon production
GO:0032695 negative regulation of interleukin-12 production
GO:0033256 I-kappaB/NF-kappaB complex
GO:0034774 secretory granule lumen
GO:0035580 specific granule lumen
GO:0035994 response to muscle stretch
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042802 identical protein binding
GO:0042805 actinin binding
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071316 cellular response to nicotine
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071359 cellular response to dsRNA
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1904385 cellular response to angiotensin
GO:2000630 positive regulation of miRNA metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000451 NF-kappa-B/DorsalFamilyFamily
IPR000488 Death domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR002909 IPT domainDomainDomain
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR011539 Rel homology domain (RHD), DNA-binding domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR030492 Rel homology domain, conserved siteSiteConserved site
IPR030503 Nuclear factor NF-kappa-B, p105 subunitFamilyFamily
IPR032397 Rel homology dimerisation domainDomainDomain
IPR033926 NFkappaB IPT domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR037059 Rel homology domain (RHD), DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00843 DonepezilDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB01041 ThalidomideDrugbanksmall molecule
DB01411 PranlukastDrugbanksmall molecule
DB05212 HE3286Drugbanksmall molecule
DB05451 P54Drugbanksmall molecule
DB05464 NOX-700Drugbanksmall molecule
DB05471 SGN-30Drugbankbiotech
DB05487 CustirsenDrugbanksmall molecule
DB05559 NF-kappaB DecoyDrugbanksmall molecule
DB05767 AndrographolideDrugbanksmall molecule
DB08814 TriflusalDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech
DB14059 SC-236Drugbanksmall molecule

Interactions

175 interactions

InteractorPartnerSourcesPublicationsLink
NFKB1_HUMANIKBE_HUMANBioGRID, HPRD, IntAct14743216 27609421 9315679 details
NFKB1_HUMANTF65_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10498867 11880271 11970949 11976329 12414801 14645533 14690596 14743216 15657065 15660126 15799966 16105840 16204234 16319923 16740634 17962807 17982102 20154269 20237821 2050119 20547752 21483817 21544861 21988832 22139845 22261743 23687337 24175631 25355951 25609649 27609421 29084252 29439025 8246997 8255759 8428580 8798655 9722548 details
NFKB1_HUMANM3K8_HUMANBioGRID, HPRD, IntAct, MINT12832462 14743216 15169888 16291755 21988832 25609649 25852190 29084252 9950430 details
NFKB1_HUMANGLNA_HUMANBioGRID, IntAct21988832 details
NFKB1_HUMANNFKB1_HUMANBioGRID, HPRD, IntAct, MINT11880271 11943214 12414801 12482991 12832462 14645533 14678988 14743216 15043934 1508666 21988832 25609649 26264872 8139561 8428580 8887676 9722548 9738011 details
NFKB1_HUMANFBW1A_HUMANBioGRID, HPRD, IntAct10835356 11158290 11953428 12482991 22388891 25900982 26112410 28514442 9990852 details
NFKB1_HUMANHMGA2_HUMANBioGRID, HPRD12693954 details
NFKB1_HUMANMEN1_HUMANBioGRID, HPRD11526476 16651450 details
NFKB1_HUMANRRP5_HUMANHPRD, IntAct14624448 details
NFKB1_HUMANIKBA_HUMANBioGRID, DIP, HPRD, IntAct, MINT11020244 11313474 14743216 16210649 17003112 20237821 20558726 20980497 21483817 21988832 22536447 25609649 26186194 26496610 27609421 28514442 29439025 7739549 7891711 8631829 8887676 9566883 9572494 9738011 9865693 details
NFKB1_HUMANHDAC1_HUMANBioGRID, HPRD, IntAct11931769 12972430 14678988 16319923 17827154 25241761 details
NFKB1_HUMANTNIP2_HUMANBioGRID, HPRD, IntAct, MINT14743216 15169888 21988832 25609649 27609421 29084252 details
NFKB1_HUMANIKKB_HUMANBioGRID, HPRD, IntAct10469655 11158290 11297557 11976329 12482991 22536447 25241761 details
NFKB1_HUMANIKKA_HUMANBioGRID, HPRD, IntAct, MINT10469655 11297557 11976329 12482991 25609649 details
NFKB1_HUMANAP2A_HUMANBioGRID19074833 details
NFKB1_HUMANSTAT3_HUMANBioGRID, HPRD, IntAct12057007 25241761 details
NFKB1_HUMANPARP1_HUMANBioGRID, HPRD, MINT11590148 16204234 16799643 25609649 details
NFKB1_HUMANHIF1N_HUMANBioGRID, DIP, MINT17003112 25609649 26972000 details
NFKB1_HUMANBCL3_HUMANBioGRID, HPRD, IntAct10362352 10469655 14678988 15829968 17962807 20547759 20558726 20800578 30833792 8428580 details
NFKB1_HUMANPPARG_HUMANBioGRID18556801 details
NFKB1_HUMANNFKB2_HUMANBioGRID, HPRD, IntAct, MINT14743216 15169888 15660126 21988832 25609649 27609421 details
NFKB1_HUMANNOTC1_HUMANBioGRID, HPRD, MINT11418662 16319921 8642313 details
NFKB1_HUMANPHS_HUMANBioGRID, IntAct20211142 details
NFKB1_HUMANNCOA6_HUMANBioGRID10847592 details
NFKB1_HUMANNCOA1_HUMANBioGRID, HPRD10847592 9556555 details
NFKB1_HUMANCENPR_HUMANBioGRID, HPRD12244126 details
NFKB1_HUMANRXRA_HUMANBioGRID, HPRD10075655 details
NFKB1_HUMANGCR_HUMANBioGRID, HPRD16380507 7823959 8290595 details
NFKB1_HUMANSPP2A_HUMANBioGRID, IntAct21988832 details
NFKB1_HUMANTNIP1_HUMANBioGRID, IntAct, MINT19695220 21988832 25609649 details
NFKB1_HUMANCSN5_HUMANBioGRID, IntAct21145461 21988832 details
NFKB1_HUMANNEMO_HUMANBioGRID, HPRD, MINT14743216 15043934 25609649 27609421 details
NFKB1_HUMANLYL1_HUMANBioGRID, HPRD10023675 details
NFKB1_HUMANT22D3_HUMANBioGRID, HPRD11468175 details
NFKB1_HUMANEP300_HUMANBioGRID11739381 12471036 12960163 14662860 20065107 22013068 23811396 details
NFKB1_HUMANREQU_HUMANBioGRID20460684 22334708 details
NFKB1_HUMANIKBZ_HUMANBioGRID, HPRD, IntAct11356851 15241416 21988832 details
NFKB1_HUMANHMGB1_HUMANBioGRID, HPRD12604365 details
NFKB1_HUMANFBX7_HUMANBioGRID32933748 details
NFKB1_HUMANRELB_HUMANBioGRID, HPRD, IntAct, MINT14743216 17962807 21988832 25609649 27609421 28514442 details
NFKB1_HUMANGSK3B_HUMANBioGRID, HPRD11425860 details
NFKB1_HUMANCHK2_HUMANBioGRID21466675 details
NFKB1_HUMANPELP1_HUMANBioGRID, IntAct20195357 details
NFKB1_HUMANCOPB2_HUMANBioGRID, IntAct, MINT14743216 21988832 25609649 27609421 details
NFKB1_HUMANSP1_HUMANBioGRID16740634 18083845 7933095 details
NFKB1_HUMANCEBPB_HUMANBioGRID, HPRD1518839 details
NFKB1_HUMANE2F1_HUMANBioGRID, HPRD9368006 details
NFKB1_HUMANMTPN_HUMANBioGRID, HPRD11971907 details
NFKB1_HUMANNR4A1_HUMANBioGRID, IntAct21988832 details
NFKB1_HUMANIRF9_HUMANBioGRID8550813 details
NFKB1_HUMANPALS2_HUMANBioGRID, IntAct20195357 details
NFKB1_HUMANELF1_HUMANBioGRID, HPRD7862168 9094628 details
NFKB1_HUMANELF3_HUMANBioGRID, HPRD11036073 23687337 details
NFKB1_HUMANHDAC5_HUMANBioGRID12917325 details
NFKB1_HUMANAPBB2_HUMANBioGRID17567906 details
NFKB1_HUMAN1433T_HUMANBioGRID, IntAct21988832 details
NFKB1_HUMANZBTB9_HUMANBioGRID, IntAct20211142 details
NFKB1_HUMANSTAT6_HUMANBioGRID, HPRD9584180 details
NFKB1_HUMANCFLAR_HUMANHPRD13679070 details
NFKB1_HUMANPLD3_HUMANBioGRID, IntAct20195357 details
NFKB1_HUMANTYY1_HUMANBioGRID, IntAct21988832 details
NFKB1_HUMANPSD10_HUMANBioGRID17904523 details
NFKB1_HUMANRN123_HUMANBioGRID25860612 28389511 28923245 details
NFKB1_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct, MINT15829968 19358846 25241761 details
NFKB1_HUMANRGS14_HUMANBioGRID, IntAct21988832 details
NFKB1_HUMANDNM3L_HUMANBioGRID24952347 details
NFKB1_HUMANBARD1_HUMANBioGRID33024116 details
NFKB1_HUMANMRP2_HUMANBioGRID, IntAct21988832 details
NFKB1_HUMANTAB2_HUMANBioGRID12150997 details
NFKB1_HUMANNKRF_HUMANBioGRID, HPRD10562553 details
NFKB1_HUMANIRF2_HUMANBioGRID, HPRD8550813 details
NFKB1_HUMANASPP2_HUMANBioGRID18448430 details
NFKB1_HUMANPML_HUMANBioGRID, IntAct21988832 details
NFKB1_HUMANHD_HUMANIntAct17500595 32814053 details
NFKB1_HUMANTRIP4_HUMANBioGRID, HPRD12077347 details
NFKB1_HUMANAACT_HUMANBioGRID, IntAct21988832 details
NFKB1_HUMANIRF8_HUMANBioGRID8550813 details
NFKB1_HUMANHMGA1_HUMANBioGRID9809067 details
NFKB1_HUMANSRF_HUMANBioGRID2108863 details
NFKB1_HUMANHSP74_HUMANBioGRID9250404 details
NFKB1_HUMANECSIT_HUMANBioGRID25355951 details
NFKB1_HUMANDPF3_HUMANBioGRID22334708 details
NFKB1_HUMANSF01_HUMANBioGRID12917325 details
NFKB1_HUMANREL_HUMANBioGRID, HPRD, IntAct, MINT14743216 15143182 17962807 25609649 26186194 27609421 28514442 details
NFKB1_HUMANATP5J_HUMANIntAct20195357 details
NFKB1_HUMANETS1_HUMANBioGRID, HPRD, IntAct25241761 9094628 details
NFKB1_HUMANFBW1B_HUMANBioGRID, HPRD, IntAct12482991 22017875 25332235 25515538 28514442 details
NFKB1_HUMANUN5CL_HUMANBioGRID, HPRD14769797 details
NFKB1_HUMANKS6A5_HUMANBioGRID20129940 details
NFKB1_HUMANIKBB_HUMANBioGRID, HPRD, IntAct14743216 26186194 27609421 28514442 details
NFKB1_HUMANCNO11_HUMANBioGRID, IntAct27173435 unassigned1312 details
NFKB1_HUMANPSA4_HUMANBioGRID8692272 details
NFKB1_HUMANBRMS1_HUMANBioGRID17000776 details
NFKB1_HUMANANXA4_HUMANBioGRID20237821 details
NFKB1_HUMANTHIO_HUMANBioGRID, HPRD, MINT25609649 7788295 details
NFKB1_HUMANKLF5_HUMANBioGRID, HPRD14573617 16102021 details
NFKB1_HUMANNCOR2_HUMANBioGRID, HPRD10777532 15494311 details
NFKB1_HUMANMAD3_HUMANBioGRID7694229 8255759 details
NFKB1_HUMANBRCA1_HUMANHPRD12700228 details
NFKB1_HUMANIL2RA_HUMANHPRD2497520 details
NFKB1_HUMANNCF1_HUMANHPRD12618429 details
NFKB1_HUMANVIME_HUMANBioGRID, MINT22536447 25609649 details
NFKB1_HUMANTP53B_HUMANBioGRID, HPRD10646849 details
NFKB1_HUMANPP4C_HUMANBioGRID, HPRD9837938 details
NFKB1_HUMANNCOA3_HUMANBioGRID15383283 details
NFKB1_HUMANUB2D3_HUMANHPRD10835356 details
NFKB1_HUMANNCOR1_HUMANBioGRID12150997 details
NFKB1_HUMANIRF1_HUMANHPRD8746784 details
NFKB1_HUMANNFRKB_HUMANHPRD2050119 details
NFKB1_HUMANJKIP1_HUMANIntAct20195357 details
NFKB1_HUMANDDX46_HUMANIntAct20195357 details
NFKB1_HUMANTB182_HUMANBioGRID, IntAct27173435 unassigned1312 details
NFKB1_HUMANCNOT2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NFKB1_HUMANSTA5A_HUMANBioGRID21763497 details
NFKB1_HUMANSARAF_HUMANIntAct20195357 details
NFKB1_HUMANSPTB2_HUMANIntAct20195357 details
NFKB1_HUMANRUVB2_HUMANBioGRID, MINT15829968 25609649 details
NFKB1_HUMANTTP_HUMANBioGRID19738286 details
NFKB1_HUMANPHF10_HUMANBioGRID22334708 details
NFKB1_HUMANTERA_HUMANBioGRID26112410 details
NFKB1_HUMANCNOT7_HUMANBioGRID, IntAct27173435 unassigned1312 details
NFKB1_HUMANMYC_HUMANBioGRID33024116 details
NFKB1_HUMANAPLP2_HUMANIntAct20195357 details
NFKB1_HUMANRSF1_HUMANBioGRID, HPRD15242768 details
NFKB1_HUMANHDAC4_HUMANBioGRID12917325 details
NFKB1_HUMANKAT5_HUMANBioGRID, HPRD15829968 details
NFKB1_HUMANZHX2_HUMANBioGRID30026228 details
NFKB1_HUMANANDR_HUMANHPRD8798655 details
NFKB1_HUMANCARM1_HUMANBioGRID14729568 details
NFKB1_HUMANP63_HUMANBioGRID21150337 details
NFKB1_HUMANCDX2_HUMANBioGRID17876541 details
NFKB1_HUMANRS3_HUMANBioGRID, HPRD, IntAct, MINT18045535 23188828 25609649 details
NFKB1_HUMANERCC6_HUMANIntAct20195357 details
NFKB1_HUMANCNO6L_HUMANBioGRID, IntAct27173435 unassigned1312 details
NFKB1_HUMANRPB1_HUMANBioGRID16319923 details
NFKB1_HUMANSOCS3_HUMANBioGRID21451109 details
NFKB1_HUMANCHK1_HUMANBioGRID33024116 details
NFKB1_HUMANTNR6B_HUMANIntAct20195357 details
NFKB1_HUMANTBB5_HUMANBioGRID, MINT22536447 25609649 details
NFKB1_HUMANHDAC3_HUMANBioGRID12972430 15494311 details
NFKB1_HUMANCA052_HUMANIntAct20195357 details
NFKB1_HUMANVDR_HUMANBioGRID26269414 details
NFKB1_HUMANSIN3A_HUMANHPRD17962807 details
NFKB1_HUMANCDK9_HUMANHPRD12173051 details
NFKB1_HUMANCNOT6_HUMANIntActunassigned1312 details
NFKB1_HUMANFOS_HUMANHPRD9468519 details
NFKB1_HUMANTWST1_HUMANDIP25266422 details
NFKB1_HUMANATF3_HUMANHPRD7692236 details
NFKB1_HUMANHMGB2_HUMANIntAct20195357 details
NFKB1_HUMANDPF1_HUMANBioGRID22334708 details
NFKB1_HUMANIASPP_HUMANBioGRID29743530 details
NFKB1_HUMANESR1_HUMANHPRD7651415 details
NFKB1_HUMANTNF11_HUMANHPRD10635328 details
NFKB1_HUMANG3BP2_HUMANHPRD10969074 details
NFKB1_HUMANCOMD1_HUMANBioGRID, IntAct15799966 details
NFKB1_HUMANVPS4A_HUMANIntAct20195357 details
NFKB1_HUMANPPME1_HUMANBioGRID19156129 details
NFKB1_HUMANPRGC1_HUMANBioGRID17785586 details
NFKB1_HUMANRIPK1_HUMANHPRD16291755 details
NFKB1_HUMANINT3_HUMANIntAct20195357 details
NFKB1_HUMANSPTN1_HUMANIntAct20195357 details
NFKB1_HUMANTEAD4_HUMANBioGRID24213609 details
NFKB1_HUMANCLUS_HUMANBioGRID20068069 details
NFKB1_HUMANTNAP3_HUMANBioGRID28923245 details
NFKB1_HUMANSFPQ_HUMANBioGRID22536447 details
NFKB1_HUMANSPI1_HUMANHPRD9094628 details
NFKB1_HUMANDYST_HUMANIntAct20195357 details
NFKB1_HUMANBANP_HUMANBioGRID18981184 details
NFKB1_HUMANKAPCA_HUMANHPRD12947093 details
NFKB1_HUMANINGR1_HUMANIntAct20195357 details
NFKB1_HUMANGRB14_HUMANIntAct20195357 details
NFKB1_HUMANHDAC2_HUMANBioGRID17827154 details
NFKB1_HUMANPLST_HUMANIntAct20195357 details
NFKB1_HUMANFBXW7_HUMANBioGRID26269414 details
NFKB1_HUMANUBE2K_HUMANHPRD9535861 details