Entity Details

Primary name CO5A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20908
EntryNameCO5A1_HUMAN
FullNameCollagen alpha-1(V) chain
TaxID9606
Evidenceevidence at protein level
Length1838
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesCOL5A1

GO terms

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GOName
GO:0001568 blood vessel development
GO:0003007 heart morphogenesis
GO:0005178 integrin binding
GO:0005201 extracellular matrix structural constituent
GO:0005576 extracellular region
GO:0005588 collagen type V trimer
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0007155 cell adhesion
GO:0008201 heparin binding
GO:0016477 cell migration
GO:0030020 extracellular matrix structural constituent conferring tensile strength
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0031012 extracellular matrix
GO:0032964 collagen biosynthetic process
GO:0035313 wound healing, spreading of epidermal cells
GO:0035989 tendon development
GO:0043394 proteoglycan binding
GO:0043588 skin development
GO:0045112 integrin biosynthetic process
GO:0046872 metal ion binding
GO:0048407 platelet-derived growth factor binding
GO:0048592 eye morphogenesis
GO:0051128 regulation of cellular component organization
GO:0062023 collagen-containing extracellular matrix
GO:0097435 supramolecular fiber organization
GO:1903225 negative regulation of endodermal cell differentiation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000885 Fibrillar collagen, C-terminalDomainDomain
IPR001791 Laminin G domainDomainDomain
IPR008160 Collagen triple helix repeatRepeatRepeat
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
130000 OMIMEhlers-Danlos syndrome, classic type, 1 (EDSCL1)A form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. The main features of classic Ehlers-Danlos syndrome are joint hypermobility and dislocation, and fragile, bruisable skin. EDSCL1 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.