Entity Details

Primary name 5NTD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21589
EntryName5NTD_HUMAN
FullName5'-nucleotidase
TaxID9606
Evidenceevidence at protein level
Length574
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesNT5E

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006195 purine nucleotide catabolic process
GO:0006196 AMP catabolic process
GO:0006259 DNA metabolic process
GO:0007159 leukocyte cell-cell adhesion
GO:0008253 5'-nucleotidase activity
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0019674 NAD metabolic process
GO:0031225 anchored component of membrane
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0046032 ADP catabolic process
GO:0046086 adenosine biosynthetic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0046872 metal ion binding
GO:0050728 negative regulation of inflammatory response
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR006146 5'-Nucleotidase, conserved siteSiteConserved site
IPR006179 5'-Nucleotidase/apyraseFamilyFamily
IPR008334 5'-Nucleotidase, C-terminalDomainDomain
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily
IPR036907 5'-Nucleotidase, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
211800 OMIMCalcification of joints and arteries (CALJA)A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00806 PentoxifyllineDrugbanksmall molecule
DB00987 CytarabineDrugbanksmall molecule