Entity Details

Primary name RYR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21817
EntryNameRYR1_HUMAN
FullNameRyanodine receptor 1
TaxID9606
Evidenceevidence at protein level
Length5038
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesRYR1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0003151 outflow tract morphogenesis
GO:0005219 ryanodine-sensitive calcium-release channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005790 smooth endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0006816 calcium ion transport
GO:0006936 muscle contraction
GO:0014701 junctional sarcoplasmic reticulum membrane
GO:0014802 terminal cisterna
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0015278 calcium-release channel activity
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0030659 cytoplasmic vesicle membrane
GO:0031000 response to caffeine
GO:0031301 integral component of organelle membrane
GO:0031674 I band
GO:0033017 sarcoplasmic reticulum membrane
GO:0034220 ion transmembrane transport
GO:0034704 calcium channel complex
GO:0042383 sarcolemma
GO:0043588 skin development
GO:0043931 ossification involved in bone maturation
GO:0048741 skeletal muscle fiber development
GO:0048763 calcium-induced calcium release activity
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051289 protein homotetramerization
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0070062 extracellular exosome
GO:0071277 cellular response to calcium ion
GO:0071313 cellular response to caffeine
GO:1903779 regulation of cardiac conduction
GO:1990425 ryanodine receptor complex

Subcellular Location

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Subcellular Location
Sarcoplasmic reticulum
Sarcoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000699 RIH domainDomainDomain
IPR001870 B30.2/SPRY domainDomainDomain
IPR003032 Ryanodine receptor RyrDomainDomain
IPR003877 SPRY domainDomainDomain
IPR005821 Ion transport domainDomainDomain
IPR009460 Ryanodine Receptor TM 4-6DomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR013333 Ryanodine receptorFamilyFamily
IPR013662 RyR/IP3R Homology associated domainDomainDomain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptorDomainDomain
IPR016093 MIR motifDomainDomain
IPR033215 Ryanodine receptor 1FamilyFamily
IPR035761 Ryanodine receptor, SPRY domain 1DomainDomain
IPR035762 Ryanodine receptor, SPRY domain 3DomainDomain
IPR035764 Ryanodine receptor, SPRY domain 2DomainDomain
IPR035910 RyR/IP3 receptor binding core, RIH domain superfamilyFamilyHomologous superfamily
IPR036300 Mir domain superfamilyFamilyHomologous superfamily
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB01219 DantroleneDrugbanksmall molecule
DB04786 SuraminDrugbanksmall molecule
DB09085 TetracaineDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
RYR1_HUMANGRB2_HUMANIntAct17474147 details
RYR1_HUMANNCK1_HUMANIntAct17474147 details
RYR1_HUMANPLCG1_HUMANIntAct17474147 details
RYR1_HUMANPP1A_HUMANMINT18755143 details
RYR1_HUMANPP2AA_HUMANMINT18755143 details
RYR1_HUMANMYOM2_HUMANBioGRID, IntAct23414517 details
RYR1_HUMANPDLI3_HUMANBioGRID, IntAct23414517 details
RYR1_HUMANTITIN_HUMANBioGRID, IntAct23414517 details
RYR1_HUMANTULP3_HUMANBioGRID, IntAct23414517 details
RYR1_HUMANFKB1A_HUMANBioGRID, DIP, HPRD11171121 11237759 11279144 12704193 18268335 details
RYR1_HUMANTRDN_HUMANBioGRID, HPRD10212196 10531621 11069905 14638677 7721813 9287354 9890886 details
RYR1_HUMANHOME1_HUMANBioGRID, HPRD12223488 12810060 14660561 details
RYR1_HUMANRYR2_HUMANBioGRID, HPRD12213830 14722100 details
RYR1_HUMANS10A1_HUMANBioGRID, HPRD9298970 details
RYR1_HUMANHOME2_HUMANBioGRID, HPRD12223488 details
RYR1_HUMANHOME3_HUMANBioGRID, HPRD12223488 details
RYR1_HUMANANK1_HUMANBioGRID7629097 details
RYR1_HUMANCALM1_HUMANBioGRID, HPRD11306590 12509414 18201104 9405457 details
RYR1_HUMANCALM2_HUMANBioGRID, HPRD11306590 12509414 18201104 9405457 details
RYR1_HUMANCALM3_HUMANBioGRID, HPRD11306590 12509414 18201104 9405457 details
RYR1_HUMANCAV3_HUMANBioGRID23071107 details
RYR1_HUMANRYR1_HUMANBioGRID, HPRD12509414 23071107 details
RYR1_HUMANAKAP6_HUMANBioGRID11590243 details
RYR1_HUMANKAPCA_HUMANHPRD14532276 8380342 details
RYR1_HUMANKGP1_HUMANHPRD14532276 8380342 details
RYR1_HUMANCAC1S_HUMANHPRD12496092 9199552 details