Entity Details

Primary name PSA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25786
EntryNamePSA1_HUMAN
FullNameProteasome subunit alpha type-1
TaxID9606
Evidenceevidence at protein level
Length263
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesPSMA1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0001530 lipopolysaccharide binding
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003723 RNA binding
GO:0004175 endopeptidase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0005844 polysome
GO:0006521 regulation of cellular amino acid metabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016579 protein deubiquitination
GO:0019773 proteasome core complex, alpha-subunit complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000426 Proteasome alpha-subunit, N-terminal domainDomainDomain
IPR001353 Proteasome, subunit alpha/betaFamilyFamily
IPR023332 Proteasome alpha-type subunitFamilyFamily
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR035144 Proteasome subunit alpha 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDEDrugbanksmall molecule

Interactions

217 interactions

InteractorPartnerSourcesPublicationsLink
PSA1_HUMANRA54B_HUMANBioGRID, HPRD, IntAct16189514 19060904 details
PSA1_HUMANVIME_HUMANBioGRID, HPRD, IntAct16189514 details
PSA1_HUMANK1C15_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
PSA1_HUMANPSA3_HUMANBioGRID, DIP, HPRD, IntAct12376572 15225636 21988832 22079093 22863883 22939629 25416956 25599644 26186194 26344197 28514442 29568061 29636472 32296183 9311996 9451443 details
PSA1_HUMANPSA4_HUMANBioGRID, DIP, HPRD, IntAct12376572 14733938 15225636 22863883 22939629 25599644 26186194 26344197 28514442 29568061 29636472 9311996 details
PSA1_HUMANPSB1_HUMANBioGRID, DIP, IntAct12376572 22863883 22939629 25599644 26186194 26344197 28292943 28514442 29568061 29636472 32296183 details
PSA1_HUMANPSB5_HUMANBioGRID, DIP, HPRD, IntAct12376572 14733938 22863883 22939629 25599644 26186194 26344197 28514442 29636472 details
PSA1_HUMANDHB14_HUMANBioGRID, IntAct19060904 31515488 details
PSA1_HUMANMARE3_HUMANBioGRID, IntAct, MINT21516116 25416956 details
PSA1_HUMANLZTS2_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANNAB2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANDYLT1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANFND11_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANZMY19_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANTEKT4_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANRPAC1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANTERA_HUMANBioGRID, IntAct23393163 25416956 32296183 details
PSA1_HUMANMKNK2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANPOMP_HUMANBioGRID, IntAct17948026 26186194 28514442 29568061 details
PSA1_HUMANPSB9_HUMANBioGRID, IntAct17948026 26186194 28514442 30833792 8206875 details
PSA1_HUMANPSA7_HUMANBioGRID, DIP, HPRD, IntAct, MINT12376572 14733938 15225636 17948026 22863883 22939629 25599644 26186194 26344197 28514442 29568061 29636472 9464850 details
PSA1_HUMANPSB2_HUMANBioGRID, DIP, HPRD, IntAct12376572 14733938 17506986 17948026 22863883 22939629 25599644 26186194 26344197 28514442 29568061 29636472 details
PSA1_HUMANPSA6_HUMANBioGRID, DIP, IntAct, MINT12376572 14733938 15225636 17948026 22863883 22939629 25599644 26186194 26344197 28514442 29636472 details
PSA1_HUMANTRI27_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANCDD_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANKRT37_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANLZTS1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANGSDMD_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANLZTL1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANPRIPO_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANNDK7_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANA4_HUMANBioGRID21832049 details
PSA1_HUMANPSA2_HUMANBioGRID, DIP, HPRD, IntAct12376572 14733938 15225636 15887188 19193609 21988832 22863883 22939629 25599644 26186194 26344197 28514442 29568061 29636472 32296183 details
PSA1_HUMANCC85B_HUMANBioGRID, HPRD, IntAct16189514 details
PSA1_HUMANHOME3_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANMARE1_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANUBX11_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANPNMA5_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANHTF4_HUMANBioGRID, IntAct25416956 31515488 details
PSA1_HUMANTRIM1_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANPNMA2_HUMANBioGRID, IntAct25416956 31515488 details
PSA1_HUMANGEPH_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANDCTP1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANFL2D_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANPRKN_HUMANBioGRID, IntAct12150907 23503661 32814053 details
PSA1_HUMANMTUS2_HUMANBioGRID, IntAct, MINT19060904 21516116 25416956 32296183 details
PSA1_HUMANLDOC1_HUMANBioGRID, IntAct19060904 25416956 32296183 details
PSA1_HUMANKRT38_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANKCTD9_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANROP1A_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANCEP72_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANMD1L1_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANNT2NC_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANCHM1A_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANKAZRN_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANK1C19_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANABI2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANMIDUO_HUMANBioGRID32296183 details
PSA1_HUMANKRA41_HUMANBioGRID32296183 details
PSA1_HUMANPSB10_HUMANBioGRID, IntAct14733938 17506986 17948026 details
PSA1_HUMANCACO2_HUMANBioGRID, HPRD, IntAct16189514 30886144 32296183 details
PSA1_HUMANSMBT1_HUMANBioGRID, IntAct21988832 details
PSA1_HUMANKRA59_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANMKRN3_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANKCTD1_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANNT2NA_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANCOG6_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANPERI_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANIPO13_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANZFAN1_HUMANBioGRID29804830 details
PSA1_HUMANKRA13_HUMANBioGRID32296183 details
PSA1_HUMANT22D4_HUMANBioGRID, HPRD, IntAct16189514 details
PSA1_HUMANCOIL_HUMANBioGRID, HPRD, IntAct16713569 details
PSA1_HUMANMR1L1_HUMANBioGRID, IntAct, MINT21516116 25416956 details
PSA1_HUMANC102B_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANITF2_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANT23O_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANREL_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANSLF2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANK1C13_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANDYDC1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANCV039_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANRFC2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANMCM6_HUMANBioGRID, HPRD, IntAct16189514 details
PSA1_HUMANACTN1_HUMANBioGRID, IntAct21988832 details
PSA1_HUMANPNMA1_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANPRD14_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANABI3_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANTRI54_HUMANBioGRID, IntAct30886144 32296183 details
PSA1_HUMANKHDR3_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANHOIL1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANHXC11_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANEHMT2_HUMANBioGRID25416956 details
PSA1_HUMANCK049_HUMANBioGRID, HPRD, IntAct16169070 details
PSA1_HUMANTRI10_HUMANBioGRID, IntAct25416956 31515488 details
PSA1_HUMANSPDEF_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANMID51_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANCRX_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANDDT4L_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANKCTD7_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
PSA1_HUMANNECA2_HUMANBioGRID, HPRD16189514 details
PSA1_HUMANCBSL_HUMANBioGRID25416956 details
PSA1_HUMANCCNH_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
PSA1_HUMANFSBP_HUMANBioGRID, IntAct16189514 19060904 details
PSA1_HUMANLDB1_HUMANBioGRID, IntAct21988832 details
PSA1_HUMANGOGA2_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANADIP_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANBAFL_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANIF4A3_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANHEXI2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANPSA1_HUMANBioGRID, IntAct14733938 28292943 29568061 details
PSA1_HUMANKCD17_HUMANBioGRID, HPRD, IntAct16189514 details
PSA1_HUMANMLH1_HUMANBioGRID, IntAct25416956 29892012 31515488 details
PSA1_HUMANIKZF1_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANCDR2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANPCY2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANRBTN2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANNOP53_HUMANBioGRID24923447 details
PSA1_HUMANNMI_HUMANBioGRID, HPRD, IntAct16189514 details
PSA1_HUMANCOAC_HUMANBioGRID, MINT21516116 details
PSA1_HUMANABCD3_HUMANBioGRID, IntAct21988832 details
PSA1_HUMANIN80E_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANMTNB_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANIKZF3_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANTRAF5_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANMSD4_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANCOX2_HUMANBioGRID, IntAct21988832 details
PSA1_HUMANCEP70_HUMANBioGRID, IntAct25416956 32296183 details
PSA1_HUMANACTN2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANP20D2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANATX1_HUMANIntAct32814053 details
PSA1_HUMANSH3B4_HUMANBioGRID, IntAct18654987 details
PSA1_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANSHLB1_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANAGR2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANHOOK2_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANSAT1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANMK01_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANIFT20_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANPHS_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANCOG4_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANLONF1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANHD_HUMANIntAct32814053 details
PSA1_HUMANGOG6A_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANEMSY_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANRGS19_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANKCTD6_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANCDN2D_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANCABP5_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANYPEL5_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANTRI23_HUMANBioGRID, IntAct19060904 25416956 30886144 details
PSA1_HUMANBACD1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANCC153_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANTENR_HUMANBioGRID25416956 details
PSA1_HUMANTRI42_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANCBS_HUMANBioGRID, IntAct25416956 31515488 details
PSA1_HUMANGO45_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANCC136_HUMANBioGRID32296183 details
PSA1_HUMANBACD2_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANCINP_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANDEFI6_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANDCTD_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANCF206_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANGNPTA_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANVMAC_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANHOMEZ_HUMANBioGRID32296183 details
PSA1_HUMANTRAF1_HUMANBioGRID, IntAct25416956 details
PSA1_HUMANGUCD1_HUMANBioGRID, IntAct32296183 details
PSA1_HUMANGBRL2_HUMANIntAct17353931 details
PSA1_HUMANEPB41_HUMANIntAct17353931 details
PSA1_HUMANPSME1_HUMANBioGRID, IntAct10799514 22939629 24429290 26186194 28514442 29568061 details
PSA1_HUMANPSD11_HUMANBioGRID22939629 26344197 30254168 details
PSA1_HUMANPSB8_HUMANBioGRID, IntAct22863883 22939629 26344197 29568061 8206875 details
PSA1_HUMANNEDD8_HUMANBioGRID16503656 details
PSA1_HUMANTFE3_HUMANIntAct17353931 details
PSA1_HUMANARP6_HUMANIntAct17353931 details
PSA1_HUMANTXNL1_HUMANBioGRID19349280 details
PSA1_HUMANTRI18_HUMANBioGRID26748699 details
PSA1_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 details
PSA1_HUMANPAK2_HUMANIntAct17353931 details
PSA1_HUMANPRS6A_HUMANBioGRID22939629 26344197 30254168 details
PSA1_HUMANF120C_HUMANBioGRID29395067 details
PSA1_HUMANIKKE_HUMANIntAct17353931 details
PSA1_HUMAN3MG_HUMANIntAct17353931 details
PSA1_HUMANPSA5_HUMANBioGRID, DIP, IntAct12376572 15225636 22863883 22939629 25599644 26186194 26344197 28514442 29568061 29636472 9464850 details
PSA1_HUMANPSMD4_HUMANBioGRID, DIP22939629 24429290 26344197 30254168 30479383 details
PSA1_HUMANPSDE_HUMANBioGRID, IntAct17323924 21733848 22939629 24429290 26344197 26496610 27428775 28821611 details
PSA1_HUMANTNIK_HUMANIntAct17353931 details
PSA1_HUMANPLK1_HUMANBioGRID, HPRD11205743 details
PSA1_HUMANZFAN5_HUMANBioGRID30254168 details
PSA1_HUMANATG5_HUMANIntAct17353931 details
PSA1_HUMANPRS8_HUMANBioGRID10799514 15831487 22939629 26344197 details
PSA1_HUMANPSMD7_HUMANBioGRID19349280 22939629 26344197 details
PSA1_HUMANFKBP8_HUMANBioGRID17573772 details
PSA1_HUMANENPP1_HUMANBioGRID27226596 details
PSA1_HUMANCRCM_HUMANIntAct17353931 details
PSA1_HUMANNOTC3_HUMANBioGRID17292860 details
PSA1_HUMANADRM1_HUMANBioGRID24429290 26344197 details
PSA1_HUMANPSMD6_HUMANBioGRID, IntAct17353931 22939629 26186194 26344197 details
PSA1_HUMANPSMD2_HUMANBioGRID21733848 22939629 26344197 details
PSA1_HUMANPRS7_HUMANBioGRID21733848 22939629 26344197 details
PSA1_HUMANRD23A_HUMANBioGRID19013454 details
PSA1_HUMANIKBA_HUMANBioGRID23393163 details
PSA1_HUMANPAAF1_HUMANBioGRID15831487 details
PSA1_HUMANDERL1_HUMANBioGRID28137758 details
PSA1_HUMANLEU1_HUMANIntAct16169070 details
PSA1_HUMANHLAB_HUMANIntAct17353931 details
PSA1_HUMANTRAF6_HUMANIntAct14743216 17353931 details
PSA1_HUMANTRM7_HUMANIntAct17353931 details
PSA1_HUMANRNC_HUMANBioGRID9464850 details
PSA1_HUMANMLP3A_HUMANBioGRID30647813 details